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UniProtKB - A0A0G2KYI1 (A0A0G2KYI1_DANRE)
Protein
Sodium channel protein
Gene
scn5lab
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: ZFIN
GO - Biological processi
- heart looping Source: ZFIN
- heart morphogenesis Source: ZFIN
- membrane depolarization during action potential Source: GO_Central
- neuronal action potential Source: GO_Central
- regulation of heart contraction Source: ZFIN
- regulation of ion transmembrane transport Source: UniProtKB-KW
- sodium ion transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Ion channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotationARBA annotation |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-DRE-5576892, Phase 0 - rapid depolarisation |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel proteinUniRule annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060908-3, scn5lab |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- voltage-gated sodium channel complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 125 – 148 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 224 – 245 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 251 – 271 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 393 – 420 | HelicalUniRule annotationAdd BLAST | 28 | |
Transmembranei | 707 – 725 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 737 – 760 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 772 – 796 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 817 – 845 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 905 – 930 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 1148 – 1167 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1188 – 1207 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1213 – 1235 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 1280 – 1300 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1387 – 1410 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 1469 – 1487 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 1499 – 1521 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 1533 – 1552 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 1600 – 1622 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 1690 – 1713 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000102312, Expressed in heart and 6 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 128 – 426 | Ion_transInterPro annotationAdd BLAST | 299 | |
Domaini | 517 – 653 | Na_trans_cytoplInterPro annotationAdd BLAST | 137 | |
Domaini | 707 – 934 | Ion_transInterPro annotationAdd BLAST | 228 | |
Domaini | 944 – 1143 | Na_trans_assocInterPro annotationAdd BLAST | 200 | |
Domaini | 1147 – 1419 | Ion_transInterPro annotationAdd BLAST | 273 | |
Domaini | 1468 – 1723 | Ion_transInterPro annotationAdd BLAST | 256 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 53 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 470 – 500 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1006 – 1103 | DisorderedSequence analysisAdd BLAST | 98 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 417 – 458 | Sequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 472 – 500 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1020 – 1035 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1043 – 1064 | Acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1065 – 1095 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000154992 |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR000048, IQ_motif_EF-hand-BS IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR024583, Na_trans_cytopl IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF06512, Na_trans_assoc, 1 hit PF11933, Na_trans_cytopl, 1 hit |
PRINTSi | PR00170, NACHANNEL |
SMARTi | View protein in SMART SM00015, IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A0G2KYI1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAILFPPGP DSLHRFTRES LAGIEQRIAE EEARNAKRYQ EDRGDVEPPK
60 70 80 90 100
PRADLEAGKQ LPRIFGDIPS ALVGVPLEDI DPFYFQNRRT FIVLNKGKAI
110 120 130 140 150
FRFSATSALY IFSPFHPIRR ASIRILVHSL FSLFIMCTIL TNCCFMAMSE
160 170 180 190 200
PAQWAKYVEY TFTGIYTFES LIKILARGFC IGPFTFLRDP WNWLDFSVIL
210 220 230 240 250
MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLAD
260 270 280 290 300
VMILTVFCLS VFALIGLQLF MGNLRQKCVR SASQCLNTTL PTYNNSTFIC
310 320 330 340 350
NNRSWASLEE FFNNEENFFK VEGAKDALIC GNASDAGKCP DGFECLKTGR
360 370 380 390 400
NPNYGYTSFD TFGWAFLSLF RLMTQDYWEN LYHHTLRSAG KAYMVFFVVV
410 420 430 440 450
IFLGSFYLVN LILAVVAMAY EEQNQATIAE ALQKEQEFQL AMEQLKKEQQ
460 470 480 490 500
AAQKAQETES ILTADVSPFS TQDKAKLERR KSSRPLSEGT GEDKPAKLDP
510 520 530 540 550
IEGIKQTHSL LVRTLSLRAR RESAVSIFNF RPVNKDSELD FADDEFSNHG
560 570 580 590 600
DSDSRGGALA LPWSRRRTSA QSSCSHSSQF FFPSFNINGK LMVAVEQNGI
610 620 630 640 650
SSQGPLTPMT PLTPLPACTM EKLKEESGQN SSNELSSMLL PQLPPEGRDR
660 670 680 690 700
ALSATSYITD AMEELEEAQQ KCHPCWYVFA HKYLVWTCSP RWLKVKEWVK
710 720 730 740 750
IMVMDPFLDL AITICIVLNT LFMALEHYPM TDEFNRMLSV GNLVFTGIFT
760 770 780 790 800
AEMVLKIIAL DPYYYFQQGW NIFDSLIVSL SLMELGLSNV EGLSVLRSFR
810 820 830 840 850
LLRVFKLAKS WPTLNTLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF
860 870 880 890 900
GKNYDLCVCK ISKDCTLPRW HMKDFFHSFL IVFRVLCGEW IETMWDCMEV
910 920 930 940 950
AGQPLCILVF MLVMVIGNLV VLNLFLALLL SSFSADNLSA PDEDGEMNNL
960 970 980 990 1000
QIAIARIQRG MLWLRQALCD FFNGNFKRRR QKAKEAKAML KLKRLSQQAH
1010 1020 1030 1040 1050
WAEGNGTAGV IERSSGAGSG EDDSYMTNPN LTISVPIAPG ESDVEFPEEE
1060 1070 1080 1090 1100
DEEEDEEEEA SASSDEEPEP CKPRDDTSLS EGSTIDLRKP GEEEDEYSEM
1110 1120 1130 1140 1150
AEEAMDPENC FPDVCVRHFK CCDINTSEGL GRAWWRLRKT CYQIVEHSWF
1160 1170 1180 1190 1200
ETFIIFMILL SSGALAFEDI YIDQRKVVKV ILEYADKIFT YIFILEMSLK
1210 1220 1230 1240 1250
WIAYGFRKYF TNYWCWLDFL IVDVSLVSLV ANTLGYSDFA AIKSLRTLRA
1260 1270 1280 1290 1300
LRPLRALSRF EGMRVVVNAL IGAIPSIMNV LLVCLIFWLI FSIMGVNLFA
1310 1320 1330 1340 1350
GKFGRCVNRT GFIYNSSDIN NRSECLEMNS TQYYWTKVKV NFDNVGAGYL
1360 1370 1380 1390 1400
ALLQVATFKG WMEIMYAAVD SRAVEEQPIK ENSLYMYLYF VIFIIFGSFF
1410 1420 1430 1440 1450
TLNLFIGVII DNFNQQKRKL GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI
1460 1470 1480 1490 1500
PRPPNPVQGF FFDLVSKQAF DILIMLLIIL NMVTMMVETD EQSPSIKHIL
1510 1520 1530 1540 1550
DCINLVFIVI FTSECILKII ALRCYFFTVS WNIFDFVVVI LSIVGIVLAD
1560 1570 1580 1590 1600
IIEKYFVSPT LFRVIRLARI GRILRLIRGA KGIRTLLFAL MMSLPALFNI
1610 1620 1630 1640 1650
GLLLFLVMFI YAIFGMANFA YVKKQGGIDD MFNFETFGNS MICLFQITTS
1660 1670 1680 1690 1700
AGWDNLLSPI LNTPPEECDP EIPHTGTNAR GNCGNPSVGI TFFVTYIIIS
1710 1720 1730 1740 1750
FLIVVNMYIA IILENFSVAT EESTEPLSED DFEMFYEVWE KFDPEATQFI
1760 1770 1780 1790 1800
EYLKLSDFAD TLSEPLRIGK PNKIKLISMD LPMVSGDKIH CLDILFAFTK
1810 1820 1830 1840 1850
RVLGESGEMD ALKQQMEEKF MMANPSKISY EPITTTLRRK QEEVSAIMIQ
1860 1870 1880 1890 1900
RSYRRHLIRR QLKQASLLYR QMTMPDADKA GDSSPESQGL IVSMIMENYA
1910 1920 1930 1940 1950
TEAEITISAT SSPPSYDSVT RATSEIFHAL IPEETNEILS EHLADAEKES
ETFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01063385 Genomic DNA No translation available. CABZ01063386 Genomic DNA No translation available. CABZ01063387 Genomic DNA No translation available. CABZ01063388 Genomic DNA No translation available. CABZ01063389 Genomic DNA No translation available. CABZ01063390 Genomic DNA No translation available. CABZ01063391 Genomic DNA No translation available. CABZ01063392 Genomic DNA No translation available. CABZ01063393 Genomic DNA No translation available. CABZ01063394 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000167854; ENSDARP00000137522; ENSDARG00000102312 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01063385 Genomic DNA No translation available. CABZ01063386 Genomic DNA No translation available. CABZ01063387 Genomic DNA No translation available. CABZ01063388 Genomic DNA No translation available. CABZ01063389 Genomic DNA No translation available. CABZ01063390 Genomic DNA No translation available. CABZ01063391 Genomic DNA No translation available. CABZ01063392 Genomic DNA No translation available. CABZ01063393 Genomic DNA No translation available. CABZ01063394 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000106123 |
Genome annotation databases
Ensembli | ENSDART00000167854; ENSDARP00000137522; ENSDARG00000102312 |
Organism-specific databases
ZFINi | ZDB-GENE-060908-3, scn5lab |
Phylogenomic databases
eggNOGi | KOG2301, Eukaryota |
GeneTreei | ENSGT00940000154992 |
Enzyme and pathway databases
Reactomei | R-DRE-5576892, Phase 0 - rapid depolarisation |
Gene expression databases
Bgeei | ENSDARG00000102312, Expressed in heart and 6 other tissues |
Family and domain databases
CDDi | cd13433, Na_channel_gate, 1 hit |
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR000048, IQ_motif_EF-hand-BS IPR001696, Na_channel_asu IPR044564, Na_chnl_inactivation_gate IPR010526, Na_trans_assoc IPR024583, Na_trans_cytopl IPR043203, VGCC_Ca_Na IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR10037, PTHR10037, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 4 hits PF06512, Na_trans_assoc, 1 hit PF11933, Na_trans_cytopl, 1 hit |
PRINTSi | PR00170, NACHANNEL |
SMARTi | View protein in SMART SM00015, IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0G2KYI1_DANRE | |
Accessioni | A0A0G2KYI1Primary (citable) accession number: A0A0G2KYI1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 22, 2015 |
Last sequence update: | June 20, 2018 | |
Last modified: | January 19, 2022 | |
This is version 46 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |