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Entry version 43 (02 Jun 2021)
Sequence version 3 (20 Jun 2018)
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Protein

Solute carrier family 12 member 2

Gene

slc12a2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:31367042).

Plays a vital role in the regulation of ionic balance and cell volume (PubMed:31367042).

Important for maintenance of endolymph volume in the otic vesicle, probably by regulating ion homeostasis (PubMed:19633174).

Also plays a role in normal development of the swim bladder (PubMed:19633174).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by bumetanide.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Symport, Transport
LigandChloride, Potassium, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-426117, Cation-coupled Chloride cotransporters

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.30.1.8, the cation-chloride cotransporter (ccc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 12 member 2Imported
Alternative name(s):
Na-K-Cl cotransporter 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slc12a2Imported
Synonyms:nkcc11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040625-53, slc12a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 209Cytoplasmic1 PublicationAdd BLAST209
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei210 – 235Discontinuously helical1 PublicationAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei210 – 221Helical1 PublicationAdd BLAST12
Intramembranei222 – 2291 Publication8
Intramembranei230 – 235Helical1 Publication6
Topological domaini236 – 238Extracellular1 Publication3
Transmembranei239 – 264Helical1 PublicationAdd BLAST26
Topological domaini265 – 283Cytoplasmic1 PublicationAdd BLAST19
Transmembranei284 – 319Helical1 PublicationAdd BLAST36
Topological domaini320 – 327Extracellular1 Publication8
Transmembranei328 – 348Helical1 PublicationAdd BLAST21
Topological domaini349 – 350Cytoplasmic1 Publication2
Transmembranei351 – 376Helical1 PublicationAdd BLAST26
Topological domaini377 – 409Extracellular1 PublicationAdd BLAST33
Transmembranei410 – 428Discontinuously helical1 PublicationAdd BLAST19
Intramembranei410 – 419Helical1 Publication10
Intramembranei420 – 4211 Publication2
Intramembranei422 – 427Helical1 Publication6
Topological domaini428 – 433Cytoplasmic1 Publication6
Transmembranei434 – 463Helical1 PublicationAdd BLAST30
Topological domaini464 – 524Extracellular1 PublicationAdd BLAST61
Transmembranei525 – 555Helical1 PublicationAdd BLAST31
Topological domaini556 – 575Cytoplasmic1 PublicationAdd BLAST20
Transmembranei576 – 591Helical1 PublicationAdd BLAST16
Topological domaini592 – 594Extracellular1 Publication3
Transmembranei595 – 625Helical1 PublicationAdd BLAST31
Topological domaini626 – 636Cytoplasmic1 PublicationAdd BLAST11
Transmembranei637 – 655Helical1 PublicationAdd BLAST19
Topological domaini656Extracellular1 Publication1
Transmembranei657 – 674Helical1 PublicationAdd BLAST18
Topological domaini675 – 1136Cytoplasmic1 PublicationAdd BLAST462

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi220N → A: Moderately impairs transporter activity. 1 Publication1
Mutagenesisi305Y → F, H or W: Severely impairs transporter activity. 1 Publication1
Mutagenesisi454Y → A: Severely impairs transporter activity. 1 Publication1
Mutagenesisi538S → A: Severely impairs transporter activity. 1 Publication1
Mutagenesisi539S → A: Severely impairs transporter activity. 1 Publication1
Mutagenesisi611Y → A: Severely impairs transporter activity. 1 Publication1
Mutagenesisi630R → A: Severely impairs transporter activity. 1 Publication1
Mutagenesisi682N → A: Severely impairs transporter activity. 1 Publication1
Mutagenesisi686S → A: Severely impairs transporter activity. 1 Publication1
Mutagenesisi972 – 1136Missing in tg414b; Lethality between 6 and 14 days post-fertilization. Early ear development appears normal. The developing otic vesicle begins to collapse at 72 hours post-fertilization, probably due loss of endolymphatic fluid, and is significantly reduced in size by 5 days post-fertilization. Hair cells appear normal and there is no evidence of reduced cell numbers or apoptosis. 1 PublicationAdd BLAST165

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004517171 – 1136Solute carrier family 12 member 2Add BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi475N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi481N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi496 ↔ 507Combined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0G2KTI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the otic vesicle at 6 days post-fertilization, with highest expression in the developing semicircular canals (at protein level). Detected in the notochord at the tailbud stage. Expressed in somites, notochord and intermediate mesoderm during early somitogenesis. Expressed in the otic vesicle from 24 hours post-fertilization onwards.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000104573, Expressed in mature ovarian follicle and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0G2KTI4, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000004706

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0G2KTI4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 73DisorderedSequence analysisAdd BLAST73
Regioni91 – 121DisorderedSequence analysisAdd BLAST31
Regioni875 – 921DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi94 – 121Polar residuesSequence analysisAdd BLAST28
Compositional biasi898 – 916Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2083, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155742

Database of Orthologous Groups

More...
OrthoDBi
254933at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR002444, NKCC1
IPR018491, SLC12_C
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11827:SF58, PTHR11827:SF58, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01207, NAKCLTRNSPRT
PR01208, NAKCLTRSPRT1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930, 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A0A0G2KTI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSASPPISAG DYLSAPEPDA LKPAGPTPSQ SRFQVDLVTE SAGDGETTVG
60 70 80 90 100
FDSSPPEYVA EPPPDGLRDS VSGGEEAKGR FRVVNFAASS PDAAPAETAQ
110 120 130 140 150
NGDTVMSEGS LHSSTGGQQH HHYDTHTNTY YLRTFGHNTI DAVPKIDFYR
160 170 180 190 200
QTAAPLGEKL IRPTLSELHD ELDKEPFEDG FANGEELTPA EESAAKDVSE
210 220 230 240 250
SKGVVKFGWI KGVLVRCMLN IWGVMLFIRM TWIVGQAGIA YSCIIVIMAT
260 270 280 290 300
VVTTITGCST SAIATNGFVR GGGAYYLISR SLGPEFGGSI GLIFAFANAV
310 320 330 340 350
AVAMYVVGFA ETVVELLMDS GLLMIDQTND IRVIGTITVI LLLGISVAGM
360 370 380 390 400
EWEAKAQIFL LVILITAIFN YFIGSFIAVD SKKKFGFFSY DAGILAENFG
410 420 430 440 450
PDFRGQTFFS VFSIFFPAAT GILAGANISG DLADPQMAIP KGTLLAILIT
460 470 480 490 500
GLVYVGVAIS AGACIVRDAT GIESNFTLIS NCTDAACKYG YDFSSCRPTV
510 520 530 540 550
EGEVSSCKFG LHNDFQVMSV VSGFSPLISA GIFSATLSSA LASLVSAPKV
560 570 580 590 600
FQALCKDNIY PGIAIFGKGY GKNNEPLRGY FLTFGIALAF ILIAELNVIA
610 620 630 640 650
PIISNFFLAS YALINFSVFH ASLANSPGWR PSFKYYNMWA SLAGAILCCV
660 670 680 690 700
VMFIINWWAA LLTNVIVLSL YIYVSYKKPD VNWGSSTQAL TYHQALTHSL
710 720 730 740 750
QLCGVADHIK TFRPQCLVMT GAPNSRPAIL HLVHAFTKNV GLMLCGHVRI
760 770 780 790 800
SSRRPNFKEL NSDMLRYQRW LLNNNSKAFY TCVVAEDLRQ GTQYMLQAAG
810 820 830 840 850
LGRLRPNTLV IGFKNDWRTG DIKEVETYIN LIHDAFDFQY GVVILRLREG
860 870 880 890 900
LDISHIQGQD DSSGMKDVVV SVDISKDSDG DSSKPSSKAT SVQNSPAVQK
910 920 930 940 950
DEDDDGKAHT QPLLKKDKKS PTVPLNVADQ RLLDASQQFQ QKQGKGTVDV
960 970 980 990 1000
WWLFDDGGLT LLIPYLIANK KKWKDCKIRV FIGGKINRID HDRRAMATLL
1010 1020 1030 1040 1050
SKFRIDFSDI TVLGDINTKP KSEGLTEFAE MIEPYKLRED DMEQEAAEKL
1060 1070 1080 1090 1100
KSEEPWRITD NELELYKAKG NRQIRLNELL KEHSSTANLI VMSMPLARKG
1110 1120 1130
AVSSALYMAW LDTLSKDLPP ILLVRGNHQS VLTFYS
Length:1,136
Mass (Da):124,112
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB58CE5774EF4411D
GO
Isoform 2 (identifier: A0A0G2KTI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     900-915: Missing.

Show »
Length:1,120
Mass (Da):122,320
Checksum:iE987563C19FE895E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7FG36E7FG36_DANRE
Solute carrier family 12 member 2
slc12a2
271Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76E → K in AAH71283 (Ref. 3) Curated1
Sequence conflicti321G → D in ACT52814 (PubMed:19633174).Curated1
Sequence conflicti819T → I in AAH71283 (Ref. 3) Curated1
Sequence conflicti819T → I in ACT52814 (PubMed:19633174).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_060837900 – 915Missing in isoform 2. CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GQ259737 mRNA Translation: ACT52814.1
CABZ01010036 Genomic DNA No translation available.
CABZ01081744 Genomic DNA No translation available.
CABZ01081745 Genomic DNA No translation available.
CABZ01081746 Genomic DNA No translation available.
CR628409 Genomic DNA No translation available.
CU459120 Genomic DNA No translation available.
CU633864 Genomic DNA No translation available.
BC071283 mRNA Translation: AAH71283.1

NCBI Reference Sequences

More...
RefSeqi
NP_001002080.1, NM_001002080.1
NP_001157126.1, NM_001163654.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000164647; ENSDARP00000131505; ENSDARG00000104573 [A0A0G2KTI4-2]
ENSDART00000169885; ENSDARP00000135730; ENSDARG00000104573 [A0A0G2KTI4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
415170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:415170

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ259737 mRNA Translation: ACT52814.1
CABZ01010036 Genomic DNA No translation available.
CABZ01081744 Genomic DNA No translation available.
CABZ01081745 Genomic DNA No translation available.
CABZ01081746 Genomic DNA No translation available.
CR628409 Genomic DNA No translation available.
CU459120 Genomic DNA No translation available.
CU633864 Genomic DNA No translation available.
BC071283 mRNA Translation: AAH71283.1
RefSeqiNP_001002080.1, NM_001002080.1
NP_001157126.1, NM_001163654.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6NPHelectron microscopy2.90A/B206-677[»]
6NPJelectron microscopy3.80B/C683-1120[»]
6NPKelectron microscopy3.60A/B206-677[»]
6NPLelectron microscopy2.90A/B206-1120[»]
SMRiA0A0G2KTI4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004706

Protein family/group databases

TCDBi2.A.30.1.8, the cation-chloride cotransporter (ccc) family

Proteomic databases

PaxDbiA0A0G2KTI4

Genome annotation databases

EnsembliENSDART00000164647; ENSDARP00000131505; ENSDARG00000104573 [A0A0G2KTI4-2]
ENSDART00000169885; ENSDARP00000135730; ENSDARG00000104573 [A0A0G2KTI4-1]
GeneIDi415170
KEGGidre:415170

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6558
ZFINiZDB-GENE-040625-53, slc12a2

Phylogenomic databases

eggNOGiKOG2083, Eukaryota
GeneTreeiENSGT00940000155742
OrthoDBi254933at2759

Enzyme and pathway databases

ReactomeiR-DRE-426117, Cation-coupled Chloride cotransporters

Gene expression databases

BgeeiENSDARG00000104573, Expressed in mature ovarian follicle and 35 other tissues
ExpressionAtlasiA0A0G2KTI4, baseline

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR013612, AA_permease_N
IPR002444, NKCC1
IPR018491, SLC12_C
IPR002443, SLC12A1/SLC12A2
IPR004842, SLC12A_fam
PANTHERiPTHR11827:SF58, PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
PF08403, AA_permease_N, 1 hit
PF03522, SLC12, 1 hit
PRINTSiPR01207, NAKCLTRNSPRT
PR01208, NAKCLTRSPRT1
TIGRFAMsiTIGR00930, 2a30, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS12A2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0G2KTI4
Secondary accession number(s): A0A0G2KGS0, C7EA90, Q6IQW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 2, 2020
Last sequence update: June 20, 2018
Last modified: June 2, 2021
This is version 43 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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