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Protein

EEF1A lysine methyltransferase 1

Gene

Eef1akmt1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.UniRule annotation

Caution

Was originally thought to be an N6-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 1UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
N(6)-adenine-specific DNA methyltransferase 2UniRule annotation
Protein-lysine N-methyltransferase N6AMT2UniRule annotation
Gene namesi
Name:Eef1akmt1Imported
Synonyms:EEF1AKMT1UniRule annotation, N6AMT2UniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1306762 Eef1akmt1

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000009849 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiA0A0G2KAX1 baseline and differential

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016366
OMAiPFLSDEC

Family and domain databases

HAMAPiMF_03187 Methyltr_EFM5, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR019369 Efm5/EEF1AKMT1
IPR029063 SAM-dependent_MTases
PANTHERiPTHR13200 PTHR13200, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0G2KAX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCQWSQTPCE MSDSEDDDIP QLSSHTLAAL QEFYAEQKQT INPGGDDKYN
60 70 80 90 100
VGVIEENWQL SQFWYSQDTA LRLAQEAINA VGEGGRIACV SAPSVYQKLR
110 120 130 140 150
ELRREDISVY IFEYDRRFAI YGDEFIFYDY NNPLDLPEGV APHSFDIVVA
160 170 180 190 200
DPPYLSEECL RKTSETIQFL TQGKILLCTG AIMEEQAAQL LGVKVCKFIP
210 220
EHSRNLANEF RCYTNYDSGL DCET
Length:224
Mass (Da):25,532
Last modified:July 22, 2015 - v1
Checksum:i313D1FAD95E1158D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5DEG5B5DEG5_RAT
EEF1A lysine methyltransferase 1
Eef1akmt1 EEF1AKMT1, N6AMT2, N6amt2
214Annotation score:
A0A096MK28A0A096MK28_RAT
EEF1A lysine methyltransferase 1
Eef1akmt1 N6amt2
58Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018059 Genomic DNA No translation available.
RefSeqiXP_006252123.1, XM_006252061.3
UniGeneiRn.7240

Genome annotation databases

EnsembliENSRNOT00000091562; ENSRNOP00000075559; ENSRNOG00000009849
GeneIDi290279

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018059 Genomic DNA No translation available.
RefSeqiXP_006252123.1, XM_006252061.3
UniGeneiRn.7240

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091562; ENSRNOP00000075559; ENSRNOG00000009849
GeneIDi290279

Organism-specific databases

CTDi221143
RGDi1306762 Eef1akmt1

Phylogenomic databases

GeneTreeiENSGT00390000016366
OMAiPFLSDEC

Enzyme and pathway databases

ReactomeiR-RNO-8876725 Protein methylation

Gene expression databases

BgeeiENSRNOG00000009849 Expressed in 10 organ(s), highest expression level in spleen
ExpressionAtlasiA0A0G2KAX1 baseline and differential

Family and domain databases

HAMAPiMF_03187 Methyltr_EFM5, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR019369 Efm5/EEF1AKMT1
IPR029063 SAM-dependent_MTases
PANTHERiPTHR13200 PTHR13200, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0G2KAX1_RAT
AccessioniPrimary (citable) accession number: A0A0G2KAX1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: November 7, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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