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Protein
Submitted name:

Sortilin-related VPS10 domain-containing receptor 2

Gene

Sorcs2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
Sortilin-related VPS10 domain-containing receptor 2Imported
Gene namesi
Name:Sorcs2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1310621 Sorcs2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei907 – 928HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000007033 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiA0A0G2K902 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini644 – 704PKDInterPro annotationAdd BLAST61

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00510000046443

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR031777 Sortilin_C
IPR031778 Sortilin_N
IPR006581 VPS10
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00801 PKD, 1 hit
PF15902 Sortilin-Vps10, 1 hit
PF15901 Sortilin_C, 1 hit
SMARTiView protein in SMART
SM00602 VPS10, 1 hit
SUPFAMiSSF49299 SSF49299, 1 hit
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A0A0G2K902-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKVLESSLW RSSDFGTTYT KLTLQPGVTT VIDNFYICPA NKRKIILVSS
60 70 80 90 100
SLGDREQSLF LSTDEGTTFQ KYPVPFLVET LLFHPKEEDK VLAYTKDSKL
110 120 130 140 150
YVSSDLGKKW TLLQEQVTKD HVFWAVSGVD DDPNLVHMEA RDLSGGYRYY
160 170 180 190 200
TCLIHNCSAQ PHTAPFPGPT DRGSLTVQDE YIFLKATSTN RTKYYVSYRR
210 220 230 240 250
SDFVLMKLPK YALPKDLQII STDEQQVFVA VQEWNQVDTY NLYQSDLRGV
260 270 280 290 300
RYSLVLENVR SSRQAEENVV IDILEVRGVK GVFLANQKVD GKVTTVITYN
310 320 330 340 350
KGRDWDYLRP PSTDMNGKPT NCQPPDCHLH LHLRWADNPY VSGTVHTKDT
360 370 380 390 400
APGLIMGAGN LGSQLVEYKE EMYITSDCGH TWRQVFEEEH HVLYLDHGGV
410 420 430 440 450
IAAIKDTSIP LKTLKFSVDE GHTWSTHNFT STSVFVDGLL SEPGDETLVM
460 470 480 490 500
TVFGHISFRS DWELVKVDFR PSFPRPCVED DYSSWDLTDL QGDHCIMGQQ
510 520 530 540 550
RSYRKRKSTS WCVKGRSFTS ALTSRVCKCR DSDFLCDYGF ERSSSSESTV
560 570 580 590 600
NKCSANFWFN PLSPPEDCVL GQTYTSSLGY RKVVSNVCEG GVDLQQSPVQ
610 620 630 640 650
LQCPLQAPRG LQVSIRGEAV AVRPREDVLF VVRQEQGDVL TTKYQVDLGD
660 670 680 690 700
GFKAMYVNLT LTGEPIRHHY ESPGIYRVSV RAENMAGHDE AVLFVQVNSP
710 720 730 740 750
LQALYLEVVP VIGINQEVNL TAVLLPLNPN LTVFYWWIGH SLQPLLSLDN
760 770 780 790 800
SVTTRFTDAG DVRVTVQAAC GNSVLQDSRL VRVLDQFQVV PLQFSRDLDT
810 820 830 840 850
FNPNTPEWRE DVGLVVTRLL SKETSIPEEL LVTVVKPGLP TIADLYVLLP
860 870 880 890 900
PPRPTRKRSL TSDKRLAAVQ QALNSHRISF ILRGGLRVLV ELRDTDAGPQ
910 920 930 940 950
RPGGSGGYWA VVVLFVIGLF AVGAFILYKF KRKRPGRTVY AQMHNEKEQE
960 970 980
MTSPVSHSED AQSAMQGNHS GVVLSINSRE MHSYLVG
Length:987
Mass (Da):110,990
Last modified:July 22, 2015 - v1
Checksum:i63D754BE5030E58F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZW09D3ZW09_RAT
Sortilin-related VPS10 domain-conta...
Sorcs2
1,158Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07015838 Genomic DNA No translation available.
AABR07015839 Genomic DNA No translation available.
AABR07015840 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000089334; ENSRNOP00000074805; ENSRNOG00000007033

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07015838 Genomic DNA No translation available.
AABR07015839 Genomic DNA No translation available.
AABR07015840 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089334; ENSRNOP00000074805; ENSRNOG00000007033

Organism-specific databases

RGDi1310621 Sorcs2

Phylogenomic databases

GeneTreeiENSGT00510000046443

Gene expression databases

BgeeiENSRNOG00000007033 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiA0A0G2K902 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR031777 Sortilin_C
IPR031778 Sortilin_N
IPR006581 VPS10
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00801 PKD, 1 hit
PF15902 Sortilin-Vps10, 1 hit
PF15901 Sortilin_C, 1 hit
SMARTiView protein in SMART
SM00602 VPS10, 1 hit
SUPFAMiSSF49299 SSF49299, 1 hit
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0G2K902_RAT
AccessioniPrimary (citable) accession number: A0A0G2K902
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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