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Entry version 27 (05 Jun 2019)
Sequence version 1 (22 Jul 2015)
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Protein
Submitted name:

ADAM metallopeptidase with thrombospondin type 1 motif, 20

Gene

Adamts20

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ADAM metallopeptidase with thrombospondin type 1 motif, 20Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adamts20Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
1307725 Adamts20

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500254729220 – 1908Sequence analysisAdd BLAST1889

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000033397 Expressed in 4 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0G2K836 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0G2K836

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini257 – 466Peptidase M12BInterPro annotationAdd BLAST210
Domaini1709 – 1908GONInterPro annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni200 – 225DisorderedSequence analysisAdd BLAST26
Regioni1266 – 1297DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1266 – 1280PolarSequence analysisAdd BLAST15

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158636

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 9 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645 ADAM_CR_2
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR012314 Pept_M12B_GON-ADAMTSs
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF08685 GON, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209 TSP1, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS51046 GON, 1 hit
PS50092 TSP1, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0G2K836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVAKWLTGL LCPISLLLTG SWEVRFHPRQ EALVKTLASY EVVTPTRVNE
60 70 80 90 100
FGDVFPQNRH FSRKKRSSGV PEPPPLRTHY RISAYGQLFQ LNLSADSAFL
110 120 130 140 150
AAGYTEVHLG TPVPGPGGRS AEPPDLRHCF YRGQVNARED HIAVFSLCGG
160 170 180 190 200
LMGTFKANDG EYFLEPVLKA DGSEHEDDHN KPHLIYRQEV KRNAFVRSQS
210 220 230 240 250
HGPCGVSENQ TEKTALPSPS FRNTTGDLNR RKGAVFGLEG ERSRLHSRSK
260 270 280 290 300
RFLSYPRYVE VMVTADAKMV RHHGQNLQHY VLTLMSIVAA IYKDSSIGNL
310 320 330 340 350
INIVIVKLVI IHSEQEGPVI SFNAATTLRN FCLWQQSQNV LDDAHPSHHD
360 370 380 390 400
TAVLITREDI CGAKEKCDTL GLAELGTLCD PSRSCSISEE NGLSAAFTIA
410 420 430 440 450
HELGHVFNVP HDDSFKCKES GTKHQYHVMA PTLNYHTSPW TWSACSQKHI
460 470 480 490 500
TEFLDTGHGE CLLDKPNGRT YDLSPQLPGS VYDGNKQCEL MFGPGSQVCP
510 520 530 540 550
YLKQCRRLWC TSAEGVHKGC RTQHMPLADG TSCGPGMHCH RGLCVTRDME
560 570 580 590 600
TRPVDGEWGP WGPYSSCSRT CGGGIRSTAR LCDRPEPRNG GRYCVGRRMK
610 620 630 640 650
FRSCNTDSCP KGKRDFREKQ CSDFDGKHFD ISGLPPNVRW LPKYSGIAVK
660 670 680 690 700
DRCKLYCRVA GTTSFYQLKD RVADGTPCGT ETNDICVQGL CRQAGCDHVL
710 720 730 740 750
NSKAKRDKCG VCGGDNSSCQ TLAGVFNSAH YGYNVVVKIP AGATNIEILQ
760 770 780 790 800
HSYSGRPEDD NYLALSDTQG NFLLNGNFVV SMAKKEINIQ GAVFEYSGSN
810 820 830 840 850
NSIERINSTD RLEAELVLQV LCVGNLYNPD VHYIFNIPIE ERSNLFSWDP
860 870 880 890 900
YGPWQDCTKM CQGLHRRKIA CIRKSDRAVV SDQSCSHLPL PLFVTERCNT
910 920 930 940 950
DCELRWHITG KSDCSSQCGQ GYRTLDVHCM KYSVHKGQTV PVGDQYCGDQ
960 970 980 990 1000
LKPPNREPCH GSCVLTRWHY SEWSQCSRSC GGGEKTRESY CVNGFGHRLA
1010 1020 1030 1040 1050
ERECQELPRV VLGNCNDFPC PGWATSEWSE CPVTCGKGMK QRQVWCQRSE
1060 1070 1080 1090 1100
DPVGDDFCDA STKPESLGPC ELRACASWHV GPWGSCTVTC GHGYQVRAVK
1110 1120 1130 1140 1150
CVSEILGTVL DDRECPRASR PSDRQVCVCI PRLSLPSCPV LSLPSCPVTE
1160 1170 1180 1190 1200
SNPWGQQSSL PCCCGNGQGL HRRKIACIRK SDRAVVSDQS CSHLPLPLFV
1210 1220 1230 1240 1250
TERVNPEEES EESDWEWVTT SCGHGKTTRR VLCVNYHQLV DESYCDPEGR
1260 1270 1280 1290 1300
PVTEQECRLA ACPPSYSRSP SSSEQPSHGP GRNVPLTHKP EENPDQGVQL
1310 1320 1330 1340 1350
SIRGNQWRTG PWGACSRRCG GLQHRAVCQD EDGRSATSCE ATSKPPESHC
1360 1370 1380 1390 1400
GSGPCPQWNY GDWGGKCTQT CGAGVKSRFV ICQFPDGQMA QEHSCELPKP
1410 1420 1430 1440 1450
PSMMQCHLRA CPDDVSWYRG SWKSCSASCG KGIKYREVLC IDQVQRKLEE
1460 1470 1480 1490 1500
KYCSHLHKPR THKPCRSGRC PSWKANKWKE CSVTCGSGVQ QREVYCRLRG
1510 1520 1530 1540 1550
TGRVAEDMCE PSTRPQVQRP CWHQDCTRYQ WTTGDWLDCS TSCKKKETYR
1560 1570 1580 1590 1600
LVKCVNERNM QVNESLCDPL TKPVSIKKCR NSHCKYMVVT GDSSQCAGNC
1610 1620 1630 1640 1650
GLTYSQRITY CTRIQPPKKN AFHHQLRPVN YGQCPVIPSP QVYKCDIRSC
1660 1670 1680 1690 1700
LRGATWKVGK WSKCSVTCGN GIMERRVACR TENGWPSDLC LKRLKPDAQK
1710 1720 1730 1740 1750
KCYANDCKLL TTCKEIQVTN NITKDGNYDL NVRGRILKIH CSGMQLENPR
1760 1770 1780 1790 1800
EYLPLVKVED NFSEIYGLRL QNPYECPFNG SRRADCACEN DYPPAGYTVF
1810 1820 1830 1840 1850
SKVRVDLASM QIKTTDLLFS RTLFGKAVPF ATAGDCYSAA RCPQGQFSIN
1860 1870 1880 1890 1900
LAGTGMKVSS TAKWLAQGRY ASVIIHRSQD GTKVYGRCGG FCGKCVPHVS

TGLPIQVL
Length:1,908
Mass (Da):212,618
Last modified:July 22, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB971BDB1D1538A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZN23D3ZN23_RAT
ADAM metallopeptidase with thrombos...
Adamts20
1,909Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0RC95M0RC95_RAT
ADAM metallopeptidase with thrombos...
Adamts20
512Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07058731 Genomic DNA No translation available.
AABR07058732 Genomic DNA No translation available.
AABR07058733 Genomic DNA No translation available.
AABR07058734 Genomic DNA No translation available.
AABR07058735 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000088223; ENSRNOP00000074456; ENSRNOG00000033397

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07058731 Genomic DNA No translation available.
AABR07058732 Genomic DNA No translation available.
AABR07058733 Genomic DNA No translation available.
AABR07058734 Genomic DNA No translation available.
AABR07058735 Genomic DNA No translation available.

3D structure databases

SMRiA0A0G2K836
ModBaseiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000088223; ENSRNOP00000074456; ENSRNOG00000033397

Organism-specific databases

RGDi1307725 Adamts20

Phylogenomic databases

GeneTreeiENSGT00940000158636

Gene expression databases

BgeeiENSRNOG00000033397 Expressed in 4 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiA0A0G2K836 baseline and differential

Family and domain databases

Gene3Di2.20.100.10, 9 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645 ADAM_CR_2
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR024079 MetalloPept_cat_dom_sf
IPR012314 Pept_M12B_GON-ADAMTSs
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF17771 ADAM_CR_2, 1 hit
PF05986 ADAM_spacer1, 1 hit
PF08685 GON, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 7 hits
PRINTSiPR01857 ADAMTSFAMILY
SMARTiView protein in SMART
SM00209 TSP1, 13 hits
SUPFAMiSSF82895 SSF82895, 11 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS51046 GON, 1 hit
PS50092 TSP1, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0G2K836_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0G2K836
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: June 5, 2019
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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