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Entry version 33 (07 Apr 2021)
Sequence version 1 (22 Jul 2015)
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Protein

HECT-type E3 ubiquitin transferase

Gene

Hecw1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hecw1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Rat genome database

More...
RGDi
1561038, Hecw1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000016046, Expressed in frontal cortex and 9 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0G2K6U6, baseline

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0G2K6U6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 302C2InterPro annotationAdd BLAST97
Domaini811 – 844WWInterPro annotationAdd BLAST34
Domaini1000 – 1033WWInterPro annotationAdd BLAST34
Domaini1253 – 1323HECTInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni393 – 537DisorderedSequence analysisAdd BLAST145
Regioni571 – 602DisorderedSequence analysisAdd BLAST32
Regioni641 – 665DisorderedSequence analysisAdd BLAST25
Regioni726 – 788DisorderedSequence analysisAdd BLAST63
Regioni876 – 920DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 444PolyampholyteSequence analysisAdd BLAST52
Compositional biasi651 – 665PolarSequence analysisAdd BLAST15
Compositional biasi743 – 757PolarSequence analysisAdd BLAST15
Compositional biasi902 – 920PolarSequence analysisAdd BLAST19

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158294

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08691, C2_NEDL1-like, 1 hit
cd00201, WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037795, C2_HECW
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR040524, HECW1_helix
IPR032348, HECW_N
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF18436, HECW1_helix, 1 hit
PF16562, HECW_N, 1 hit
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045, SSF51045, 2 hits
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A0G2K6U6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN
60 70 80 90 100
IDIRNGAHDG ITIPRSTSDT DLVTSDSRST LMVSSSYYSI GYSQDLVIHW
110 120 130 140 150
DIKEEVDAGD WIGMYLIGEV SSENFLDYKN RGVNGSHRGQ IIWKIDASSY
160 170 180 190 200
FVESETKICF KYYHGVSGAL RATTPSVTVK NSAAPIFKGI GSEETVQSQG
210 220 230 240 250
NRRLISFSLS DFQAMGLKKG MFFNPDPYLK ISIQPGKHSI FPALPHHGQE
260 270 280 290 300
RRSTIIGNTV NPIWQAEHFS FVSLPTDVLE IEVKDKFAKS RPIIKRFLGK
310 320 330 340 350
LSMPVQRLLE RHAIGDRVVS YTLGRRLPTD HVSGHLQFRF EITSSIHADD
360 370 380 390 400
EEISLNAEPE SAEVQDSVMN SVVENSSGEP PGDAAEFLKD LKPEAPSEED
410 420 430 440 450
GVRGSENENR EHARPVEEAA GAMETRDDSK FSEGPEEVGE LQDPEQHDTQ
460 470 480 490 500
PTLSAEEVAE RLPLGEGCPP SLLPEESTAL GSKAEEEAIP ENGAGEEEMQ
510 520 530 540 550
EKGKDEEEEE GVSALEQGEP GLELRASVRK KSRPCSLPVS ELETVIASAC
560 570 580 590 600
GEAETPRTHY IRIHTLLHSM PSAQRGSTTE EEDAMEEEST LKESSEKDGL
610 620 630 640 650
SEVDTIAADP QSMEDGENNG ATLCMASSDC SGGHFSNLSK SIGAGQDGEA
660 670 680 690 700
HPSTGSESDS SPQQGADHSC EGCDASCCSP SCYSTSCYSS SCYSSSCYSS
710 720 730 740 750
SCYNGNNRFA SHTRFSSVDS AKISESTVFS SQEDEEEENS AFESVPDSVQ
760 770 780 790 800
SPELDPESTN GAGPWQDELA APGGNAARTT EGDCPMLHNS QPISQLPSLR
810 820 830 840 850
PEHHHYPTID EPLPPNWEAR IDSHGRVFYV DHVNRTTTWQ RPSMAPTPDG
860 870 880 890 900
MIRSGSVHQM EQLNRRYQNI QRTIATERSE EDSGNQSCEQ IPDGGAGGGG
910 920 930 940 950
SDSEAESSQS NLDLRREGSL SPVNSQKVTL LLQSPAVKFI TNPEFFTVLH
960 970 980 990 1000
ANYSAYRVFT SSTCLKHMIL KVRRDARNFE RYQHNRDLVN FINMFADTRL
1010 1020 1030 1040 1050
ELPRGWEIKT DHQGKSFFVD HNSRATTFID PRIPLQNGRL PNHLTHRQHL
1060 1070 1080 1090 1100
QRLRSYSAGE ASEVSRNRGA SLLARPGHSL IAAIRSQHQH ESLPLAYNDK
1110 1120 1130 1140 1150
IVAFLRQPNI FEMLQERQPS LARNHTLREK IHYIRTEGNH GLEKLSCDAD
1160 1170 1180 1190 1200
LVILLSLFEE EIMSYVPLQS AFHPGYSFSP RCSPCSSPQN SPGLQRASAR
1210 1220 1230 1240 1250
APSPYRRDFE AKLRNFYRKL EAKGFGQGPG KIKLIIRRDH LLEGTFNQVM
1260 1270 1280 1290 1300
AYSRKELQRN KLYITFVGEE GLDYSGPSRE FFFLLSQELF NPYYGLFEYS
1310 1320 1330
ANDTYTVQIS PMSAFVENYL EWFTESQCQG PFTVPKGF
Length:1,338
Mass (Da):148,967
Last modified:July 22, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE9F8757950785D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M4Q8F1M4Q8_RAT
HECT-type E3 ubiquitin transferase
Hecw1 RGD1561038_predicted, rCG_45267
1,594Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07028022 Genomic DNA No translation available.
AABR07028023 Genomic DNA No translation available.
AABR07028024 Genomic DNA No translation available.
AABR07028025 Genomic DNA No translation available.
AABR07028026 Genomic DNA No translation available.
AABR07028027 Genomic DNA No translation available.
AABR07028028 Genomic DNA No translation available.
AABR07028029 Genomic DNA No translation available.
AABR07028030 Genomic DNA No translation available.
AABR07028031 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000082040; ENSRNOP00000073947; ENSRNOG00000016046

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07028022 Genomic DNA No translation available.
AABR07028023 Genomic DNA No translation available.
AABR07028024 Genomic DNA No translation available.
AABR07028025 Genomic DNA No translation available.
AABR07028026 Genomic DNA No translation available.
AABR07028027 Genomic DNA No translation available.
AABR07028028 Genomic DNA No translation available.
AABR07028029 Genomic DNA No translation available.
AABR07028030 Genomic DNA No translation available.
AABR07028031 Genomic DNA No translation available.

3D structure databases

SMRiA0A0G2K6U6
ModBaseiSearch...

Genome annotation databases

EnsembliENSRNOT00000082040; ENSRNOP00000073947; ENSRNOG00000016046

Organism-specific databases

RGDi1561038, Hecw1

Phylogenomic databases

GeneTreeiENSGT00940000158294

Enzyme and pathway databases

UniPathwayiUPA00143

Gene expression databases

BgeeiENSRNOG00000016046, Expressed in frontal cortex and 9 other tissues
ExpressionAtlasiA0A0G2K6U6, baseline

Family and domain databases

CDDicd08691, C2_NEDL1-like, 1 hit
cd00201, WW, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037795, C2_HECW
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR040524, HECW1_helix
IPR032348, HECW_N
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF18436, HECW1_helix, 1 hit
PF16562, HECW_N, 1 hit
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00456, WW, 2 hits
SUPFAMiSSF51045, SSF51045, 2 hits
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0G2K6U6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0G2K6U6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: April 7, 2021
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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