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Protein

Spectrin beta chain

Gene

Sptbn4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin cappingUniRule annotation, Actin-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-375165 NCAM signaling for neurite out-growth
R-RNO-445095 Interaction between L1 and Ankyrins
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chainUniRule annotation
Gene namesi
Name:Sptbn4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1304682 Sptbn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiA0A0G2K677

Expressioni

Gene expression databases

BgeeiENSRNOG00000055371 Expressed in 10 organ(s), highest expression level in brain

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028393

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 166Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini181 – 286Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini2415 – 2524PHInterPro annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili121 – 141Sequence analysisAdd BLAST21
Coiled coili465 – 499Sequence analysisAdd BLAST35
Coiled coili627 – 647Sequence analysisAdd BLAST21
Coiled coili737 – 771Sequence analysisAdd BLAST35
Coiled coili1121 – 1141Sequence analysisAdd BLAST21
Coiled coili1441 – 1468Sequence analysisAdd BLAST28
Coiled coili1659 – 1686Sequence analysisAdd BLAST28
Coiled coili2012 – 2032Sequence analysisAdd BLAST21
Coiled coili2079 – 2099Sequence analysisAdd BLAST21
Coiled coili2282 – 2302Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the spectrin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118813
KOiK06115
OMAiHACELWI

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 14 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 16 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0G2K677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQVPGEVDN MEGPAASNNN NPAARWESPD RGWDREPPAA ANAAASLFEC
60 70 80 90 100
SRIKALADER EAVQKKTFTK WVNSHLARVG CHIGDLYADL RDGFVLTRLL
110 120 130 140 150
EVLSGEQLPR PTRGRMRIHS LENVDKALQF LKEQRVHLEN VGSHDIVDGN
160 170 180 190 200
HRLTLGLVWT IILRFQIQVI KIETEDNRET RSAKDALLLW CQMKTAGYPE
210 220 230 240 250
VNIQNFTTSW RDGLAFNALI HRHRPDLVDL SKLTKSNANY NLQRAFRTAE
260 270 280 290 300
QHLGLARLLD PEDVNMEAPD EKSIITYVVS FYHYFSKMKA LAVEGKRIGK
310 320 330 340 350
VLDQVLEVDK IIERYEELAA ELLAWIHRTV DLISNQKFAN SLSGVQQQLQ
360 370 380 390 400
AFTAYCTLEK PVKFQEKGNL EVLLFSIQSK LRAHNRRLFV PREGCGIWDI
410 420 430 440 450
DKAWGELEKA EHEREAALRA ELIRQEKLEL LAQRFDHKVA MRESWLNENQ
460 470 480 490 500
RLVSQDNFGY ELPAVEAAMK KHEAIEADIA AYEERVQGVA ELAQALAAEG
510 520 530 540 550
YYDARRVAAQ RDSVLRQWAL LTGLVGARRT RLEQNLALQK VFQEMVYMVD
560 570 580 590 600
WMEEMQTQLL SRECGQHLVE ADDLLQKHGL LEGDIAAQSE RVEALNAAAL
610 620 630 640 650
RFSQLQGYQP CDPQVICNRV NHVHGCLSEL QEQAARRRAE LEASRSLWAL
660 670 680 690 700
LQELEEAESW ARDKERLLEA TSGSGGAAGT AGGAHDLSST ARLLAQHKIL
710 720 730 740 750
QGELGGRRAL LQQALRRGEE LAAAGGSVGP GAEPLHLAGL AERAASARRR
760 770 780 790 800
WQRLEEAAAR RERRLQEARA LHQFGADLDG LLDWLRDAYR LAAAGDFGHD
810 820 830 840 850
EASSRRLARQ HRALTGEVEA HRGPVGGLRR QLATLGGASG AGPLVVALQV
860 870 880 890 900
RVVEAEQLFA EVTEVAALRR QWLRDALAVY RMFGEVHACE LWIGEKEQWL
910 920 930 940 950
LAMRVPDSLD DVEVVQHRFE SLDQEMNSLM GRVLDVNQTV QELVEGGHPS
960 970 980 990 1000
SDEVRSCQDH LNSRWNRIVE LVEQRKEEMS AVLLVENHVL EVAEVRAQVR
1010 1020 1030 1040 1050
EKRRAVESAP RAGGALQWRL SGLEAALQAL EPRQAALLEE AALLAERFPA
1060 1070 1080 1090 1100
QATRLHQGAE ELGAEWGALA GAAQACGEAV AAAGRLQRFL RDLDTFLDWL
1110 1120 1130 1140 1150
VRAQEAAGAV EGPLPRSLEE ADGLLARHAA LKEEVDQREE DYARIVAASE
1160 1170 1180 1190 1200
ALLASDGAEL GPGLALDEWL PHLEVGWHKL LGLWEERREA LVQAHVYQLF
1210 1220 1230 1240 1250
LRDLCQALAV LRNQEVALSG AELPCTVESV EEAMKRHRDF LTTMELNQQK
1260 1270 1280 1290 1300
MQVAVQAAEG LLRQGNAYGE QAQEAVARLL EKSQENQLRA QQWMQKLLDQ
1310 1320 1330 1340 1350
LVLQHFLRDC HELDGWIHEK MLMARDGTRE DSHKLHKRWL RHQAFMAELA
1360 1370 1380 1390 1400
QNKEWLEKIE REGQQLMQEK PELAASVRKK LGEIRQCWAE LESTTQAKAR
1410 1420 1430 1440 1450
QLFEASKADQ LVQSFAELDK RLLHMESQLQ DVDPGGDLAT VNSQLKKLQS
1460 1470 1480 1490 1500
MESQVEEWCR EVGELQAQTA ALPLEQASKE LVGERQSAVG ERLVRLLEPL
1510 1520 1530 1540 1550
QERRRLLLAS KELHQVAHDL DDELAWVQER LPLAMLTERG TGLQAVQQHI
1560 1570 1580 1590 1600
KKNQGLRREI QAHGPRLEEV LERAGVLASL RSPEAEAVRR GQEQLQSAWT
1610 1620 1630 1640 1650
GLREATERRQ QTLDAAFQVE QYYFDVAEVE AWLGEQELLM MSEDKGKDEQ
1660 1670 1680 1690 1700
STLQLLKKHL QLEQGVENYE ESIAQLSRQC RALLEMGHPD SEQISRRQSQ
1710 1720 1730 1740 1750
VDRLYVALKE LGEERRVSLE QQYWLYQLSR QVDELEHWIA EKEVVAGSPE
1760 1770 1780 1790 1800
LGQDFEHVSV LQEKFSEFAS ETGTAGRERL AAVNQMVDEL IECGHTAAAT
1810 1820 1830 1840 1850
MAEWKDGLNE AWAELLELMG TRAQLLAASR ELHKFFSDAR ELQGQIEEKR
1860 1870 1880 1890 1900
RRLPRLTAPP EPRPSASSMQ RTLRAFEHDL QLLVSQVRQL QEGAAQLRTV
1910 1920 1930 1940 1950
YAGEHAEAIA SREQEVLQGW KELLAACEDA RLHVSSTADA LRFHSQARDL
1960 1970 1980 1990 2000
LSWMDGIAGQ IGAADKPRDV SSVEVLMNYH QGLKTELEAR VPELTACQEL
2010 2020 2030 2040 2050
GRSLLLNKSA MADEIQAQLD KLGSRKEEVS EKWDRHWEWL QQMLEVHQFA
2060 2070 2080 2090 2100
QEAVVADAWL TAQEPLLQSR ELGSSVDEVE QLIRRHEAFR KAAAAWEERF
2110 2120 2130 2140 2150
SSLRRLTTIE KLKAEQSKQP PTPLLGRKFF GDPTELAAKA APLLRPGGYD
2160 2170 2180 2190 2200
RGLEPLARRA SDTLSAEVRT RVGYVRQELK PERLQPRIDR LPETSGKVEP
2210 2220 2230 2240 2250
AAPTAAALDT TDTPGTPAVT EQVRPRPERQ ELADRAEELP RRRRSERQES
2260 2270 2280 2290 2300
TDQPEEAARR RRPERQESAD HEGPHSLTLG RYEQMERRRE RRERRIERQE
2310 2320 2330 2340 2350
SSEQETPTRG ELVKGKATLA DIVEQLQEKE AGPGLPAAVP SLPQPRELPP
2360 2370 2380 2390 2400
GRLPNGLEPP ERTPRPDRPR ARDRPKPRRR PRPREGGEGG GSRRSRSAPA
2410 2420 2430 2440 2450
QGGSAPAPPP PPTHTVQHEG FLLRKRELDA NRKSSNRSWV NLYCVLSKGE
2460 2470 2480 2490 2500
LGFYKDSKGP ASGGTHGGEP LLSLHKATSE VASDYKKKKH VFKLQTQDGS
2510 2520 2530 2540 2550
EFLLQAKDEE EMNGWLEAVA NSVAEHAEIA RWGQTLPTTS STDEGNPKRE
2560
GGERRASGRR K
Length:2,561
Mass (Da):288,817
Last modified:July 22, 2015 - v1
Checksum:iCA5C533890C256F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118914 Genomic DNA No translation available.
AC123095 Genomic DNA No translation available.
RefSeqiNP_001094315.2, NM_001100845.2
UniGeneiRn.63104

Genome annotation databases

EnsembliENSRNOT00000077651; ENSRNOP00000073706; ENSRNOG00000055371
GeneIDi308458
KEGGirno:308458

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118914 Genomic DNA No translation available.
AC123095 Genomic DNA No translation available.
RefSeqiNP_001094315.2, NM_001100845.2
UniGeneiRn.63104

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028393

Proteomic databases

PaxDbiA0A0G2K677

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077651; ENSRNOP00000073706; ENSRNOG00000055371
GeneIDi308458
KEGGirno:308458

Organism-specific databases

CTDi57731
RGDi1304682 Sptbn4

Phylogenomic databases

GeneTreeiENSGT00760000118813
KOiK06115
OMAiHACELWI

Enzyme and pathway databases

ReactomeiR-RNO-375165 NCAM signaling for neurite out-growth
R-RNO-445095 Interaction between L1 and Ankyrins
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6807878 COPI-mediated anterograde transport

Gene expression databases

BgeeiENSRNOG00000055371 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 14 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 16 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0G2K677_RAT
AccessioniPrimary (citable) accession number: A0A0G2K677
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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