UniProtKB - A0A0G2K2B4 (A0A0G2K2B4_RAT)
Protein
Submitted name:
Nuclear receptor corepressor 1
Gene
Ncor1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- histone deacetylase binding Source: Ensembl
- nuclear hormone receptor binding Source: Ensembl
- RNA polymerase II activating transcription factor binding Source: Ensembl
- transcription corepressor activity Source: Ensembl
GO - Biological processi
- negative regulation of androgen receptor signaling pathway Source: Ensembl
- negative regulation of fatty acid metabolic process Source: Ensembl
- negative regulation of glycolytic process Source: Ensembl
- negative regulation of JNK cascade Source: Ensembl
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- spindle assembly Source: Ensembl
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-RNO-350054, Notch-HLH transcription pathway R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-RNO-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear receptor corepressor 1Imported |
Gene namesi | Name:Ncor1Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3612, Ncor1 |
Subcellular locationi
Cytoskeleton
- mitotic spindle Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Nucleus
- Sin3 complex Source: Ensembl
Other locations
- transcription repressor complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000055246, Expressed in spleen and 21 other tissues |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: Ensembl
- nuclear hormone receptor binding Source: Ensembl
- RNA polymerase II activating transcription factor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000054491 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 436 – 487 | SANTInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 117 | DisorderedSequence analysisAdd BLAST | 117 | |
Regioni | 145 – 178 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 207 – 232 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 498 – 872 | DisorderedSequence analysisAdd BLAST | 375 | |
Regioni | 999 – 1023 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1206 – 1244 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1398 – 1506 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 1646 – 1736 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 1812 – 1834 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1861 – 1907 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 1920 – 2020 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 2046 – 2135 | DisorderedSequence analysisAdd BLAST | 90 | |
Regioni | 2263 – 2357 | DisorderedSequence analysisAdd BLAST | 95 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 309 – 329 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 39 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 47 – 70 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 101 – 116 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 164 – 178 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 505 – 571 | PolyampholyteSequence analysisAdd BLAST | 67 | |
Compositional biasi | 605 – 620 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 676 – 695 | AcidicSequence analysisAdd BLAST | 20 | |
Compositional biasi | 696 – 725 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 740 – 770 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 815 – 843 | PolyampholyteSequence analysisAdd BLAST | 29 | |
Compositional biasi | 847 – 861 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1206 – 1222 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1440 – 1485 | PolarSequence analysisAdd BLAST | 46 | |
Compositional biasi | 1664 – 1709 | PolyampholyteSequence analysisAdd BLAST | 46 | |
Compositional biasi | 1814 – 1829 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1884 – 1900 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1974 – 2002 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 2046 – 2088 | PolarSequence analysisAdd BLAST | 43 | |
Compositional biasi | 2103 – 2117 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2299 – 2335 | PolarSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the N-CoR nuclear receptor corepressors family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1878, Eukaryota |
GeneTreei | ENSGT00940000155093 |
OMAi | PNREWEE |
OrthoDBi | 12227at2759 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR031557, N-CoR_GPS2_interact IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF15784, GPS2_interact, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51293, SANT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A0G2K2B4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSGYPPNQ GAFSTEQSRY PSQSVQYTFP STRHQQEFAV PDYRSSHIEV
60 70 80 90 100
SQASQLLQQQ QQQQQLRRRP SLLSEFHPGS DRPQERRTGY EQFHSGPSPV
110 120 130 140 150
DHDSLESKRP RLEPVSDAHF QRVSAAVLPL VHTLPEGLRA SADAKKDSAF
160 170 180 190 200
GGKHEAPSSP LAGQPCGDDQ NASPSKLSKE ELIQSMDRVD REIAKVEQQI
210 220 230 240 250
LKLKKKQQQL EEEAAKPPEP EKPVSPPPVE QKHRSIVQII YDENRKKAEE
260 270 280 290 300
AHKIFEGLGP KVELPLYNQP SDTKVYHENI KTNQVMRKKL ILFFKRRNHA
310 320 330 340 350
RKQREQKICQ RYDQLMEAWE KKVDRIENNP RRKAKESKTR EYYEKQFPEI
360 370 380 390 400
RKQREQQERF QRVGQRGAGL SATIARSEHE ISEIIDGLSE QENNEKQMRQ
410 420 430 440 450
LSVIPPMMFD AEQRRVKFIN MNGLMEDPMK VYKDRQFMNV WTDHEKEIFK
460 470 480 490 500
DKFIQHPKNF GLIASYLERK SVPDCVLYYY LTKKNENYKA LVRRNYGKRR
510 520 530 540 550
GRNQQIARPS QEEKVEEKEE DKAEKMEKKE EEKKDDEEKD EKEESKETTK
560 570 580 590 600
EKDRTEATAE ETEEREQVTP RGRKTANSQG RRKGRITRSM TSEAAAASAA
610 620 630 640 650
AAATEEPPPP LPPPPEPVST EPVETSRWTE EEMEVAKKGN IQQCIIYNSA
660 670 680 690 700
SRKPREERDV SQCESVASTV SAQEDEDIEA SNEEENPEDS EGAENSSDTE
710 720 730 740 750
SAPSPSPVEA AKSSEDSSEN AASRGNTEPV AELEATTDPA PCASPSSAVP
760 770 780 790 800
TTKPAESESV EAQVTDSASV ETAEPMDVDH EECGAQGSSV LDPPAPTKAD
810 820 830 840 850
SVDPEIQVPE NTASKGEGDA KDRDLESASE KTEARDEDLV VAEQMQRPEP
860 870 880 890 900
QSDNDSSATC SADEDVDGEP ERQRVFPMDA KPSLLNPPGS ILISSPIKPN
910 920 930 940 950
PLDLPQLQHR AAVIPPMVSC TPCNIPIGTP VSGYALYQRH IKAMHESALL
960 970 980 990 1000
EEQRQRQEQI DLECRSSTSP CGTSKSPNRE WEVLQPAPHQ VITNLPEGVR
1010 1020 1030 1040 1050
LPTTRPTRPP PPLIPSSKTT VASEKPSFIM GGSISQGTPG TYLTSHSQAY
1060 1070 1080 1090 1100
TPEAAKPSVG SISLGLPRQQ ESTKSAPLTY IKQEEFSPRS QNSQPEGLLV
1110 1120 1130 1140 1150
RAQHEGVVRG TAGAVQEGSI TRGTPASKIS VESISSLRGS ITQGTPALPQ
1160 1170 1180 1190 1200
AGIPTEALVK GPVSRMPIEE SSPEKVREEA ASKGHVIYEG KSGHILSYDN
1210 1220 1230 1240 1250
IKNAREGTRS PRTAHEMSLK RSYESVEGNV KQGMSMRESP VSAAPLEERT
1260 1270 1280 1290 1300
VLSGSIMQGT PRATAESFED GLKYPKQIKR ESPPSRAFEG AITKGKPYDG
1310 1320 1330 1340 1350
ITTIKEMGRS IHEIPRQDIL TQESRKTPEV VQSTRPIIEG SISQGTPIKF
1360 1370 1380 1390 1400
DNNSGQSAIK HNVKSLITGP SKLPRGMLEI VPENIKVVER GKYEDVKAGE
1410 1420 1430 1440 1450
PVRPRHTSVV SSGPSVLRST LHEAPKAQLS PGIYDDSSAR RTPVSYQNTI
1460 1470 1480 1490 1500
SRGSPMMNRT SDGSSSKTTS HERKSALTPT QRESVPAKSP VPAVDSVVSH
1510 1520 1530 1540 1550
SPFDPHHRST TAGEVYRSHL PTHLDPAMPF HRALDPAAAY LFQRQLSPTP
1560 1570 1580 1590 1600
GYPSQYQLYA MENTRQTILN DYITSQQMQV NLRPDVARGL SPREQPLGLP
1610 1620 1630 1640 1650
YPATRGIIDL TNMPPTILVP HAGGTSTPPM DRITYIPGTQ ITFPPRPYNA
1660 1670 1680 1690 1700
ASLSPGHPTH LAAAASAERE REREREKERE RERERERERE RERERERERE
1710 1720 1730 1740 1750
RERERITAAP TDLYLRPGSE QPGRPGSHGY VRSPSPSVRT QETMLQQRPS
1760 1770 1780 1790 1800
VFQGTNGTSV ITPLDPTAQL RIMPLPSGGP SISQGLPASR YNTAADALAA
1810 1820 1830 1840 1850
LVDAAASAPQ MDVSKTKESK HEAARLEDNV RSRSAAVSEQ QQLEQKNLEV
1860 1870 1880 1890 1900
EKRSVQCVCT SSALPSGKPQ PHASVVYSEA GKDKGPPPKS RYEEELRTRG
1910 1920 1930 1940 1950
KTTITAANFI DVIITRQIAS DKDARERGSQ SSDSSSSLSS HRYEAPSDAI
1960 1970 1980 1990 2000
EVISPASSPA PPQEKPQAYQ PEMVKANQAE NESPQQYEGP LHHYRSQQGS
2010 2020 2030 2040 2050
PSPQQQPPLP PSSQAEGMGQ VPRTHRLITL ADHICQIITQ DFARNQVPSQ
2060 2070 2080 2090 2100
PSTSTFQTSP SALSSTPVRT KPSSRYSPES QSQTVLHPRP GPRVSPENLV
2110 2120 2130 2140 2150
DKSRGSRPGK SPERSHIPSE PYEPISPPQG PAVHEKQDSM LLLSQRGMDP
2160 2170 2180 2190 2200
AEQRSDSRSP GSISYLPSFF TKLESTSPMV KSKKQEIFRK LNSSGGGDSD
2210 2220 2230 2240 2250
MAAAQPGTEI FNLPAVTTSG AVSSRSHSFA DPASNLGLED IIRKALMGSF
2260 2270 2280 2290 2300
DDKVEDHGVV MPHPVGVVPG SASTSVVTSS ETRRDEGDPS PHSGVCKPKL
2310 2320 2330 2340 2350
INKSNSRKSK SPIPGQNYLG TERPSSVSSV HSEGDYHRQT PGWAWEDRPS
2360 2370 2380 2390 2400
STGSTQFPYN PLTIRMLSST PPTPIACAPS AITQAAPHQQ SRIWEREPAP
2410
LLSAQYETLS DSDD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ9WUB5 | NCOR1_RAT | Nuclear receptor corepressor 1 | Ncor1 | 533 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07029733 Genomic DNA No translation available. AABR07029734 Genomic DNA No translation available. AABR07029735 Genomic DNA No translation available. AABR07029736 Genomic DNA No translation available. |
RefSeqi | NP_001258032.1, NM_001271103.1 |
Genome annotation databases
Ensembli | ENSRNOT00000081409; ENSRNOP00000072175; ENSRNOG00000055246 |
GeneIDi | 54299 |
KEGGi | rno:54299 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07029733 Genomic DNA No translation available. AABR07029734 Genomic DNA No translation available. AABR07029735 Genomic DNA No translation available. AABR07029736 Genomic DNA No translation available. |
RefSeqi | NP_001258032.1, NM_001271103.1 |
3D structure databases
SMRi | A0A0G2K2B4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000054491 |
Proteomic databases
jPOSTi | A0A0G2K2B4 |
PaxDbi | A0A0G2K2B4 |
Genome annotation databases
Ensembli | ENSRNOT00000081409; ENSRNOP00000072175; ENSRNOG00000055246 |
GeneIDi | 54299 |
KEGGi | rno:54299 |
Organism-specific databases
CTDi | 9611 |
RGDi | 3612, Ncor1 |
Phylogenomic databases
eggNOGi | KOG1878, Eukaryota |
GeneTreei | ENSGT00940000155093 |
OMAi | PNREWEE |
OrthoDBi | 12227at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-RNO-350054, Notch-HLH transcription pathway R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-RNO-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
Gene expression databases
Bgeei | ENSRNOG00000055246, Expressed in spleen and 21 other tissues |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR031557, N-CoR_GPS2_interact IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF15784, GPS2_interact, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51293, SANT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0G2K2B4_RAT | |
Accessioni | A0A0G2K2B4Primary (citable) accession number: A0A0G2K2B4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 22, 2015 |
Last sequence update: | July 22, 2015 | |
Last modified: | December 2, 2020 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |