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Protein
Submitted name:

Desmoglein 3

Gene

Dsg3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-351906 Apoptotic cleavage of cell adhesion proteins
R-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Submitted name:
Desmoglein 3Imported
Gene namesi
Name:Dsg3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1592103 Dsg3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500254706424 – 1043Sequence analysisAdd BLAST1020

Expressioni

Gene expression databases

BgeeiENSRNOG00000016632
ExpressionAtlasiA0A0G2K294 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 155CAInterPro annotationAdd BLAST86
Domaini179 – 265CAInterPro annotationAdd BLAST87
Domaini288 – 382CAInterPro annotationAdd BLAST95
Domaini409 – 493CAInterPro annotationAdd BLAST85

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00910000144083
OMAiCCSFIAD

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits

Sequencei

Sequence statusi: Complete.

A0A0G2K294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLFPRALR LLSLLMVVLM VYGELHIESG GQHREDRMAL QLTKRRYKRE
60 70 80 90 100
WVKFAKPCRE REDNSKRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF
110 120 130 140 150
VVDPNNGDIN ITAIVDREET PSFLITCRAL NALGQDVERP LILTVKILDV
160 170 180 190 200
NDNAPIFSQT IFKGEIEENS ASNSLVMILN ATDADEPNHM NSKIAFKIVS
210 220 230 240 250
QEPAGMSMFL ISRNTGEVRT LTSSLDREQV GSYHLIVSGA DNDGTGLSTQ
260 270 280 290 300
CECSIKIKDV NDNFPVLTDS QYSARIEENT LNSELLRFQV TDWDEEYTDN
310 320 330 340 350
WLAVYFFTSG NEGNWFEIET DPRTNEGILK LVKVLDYEQM QSMQFSIAVR
360 370 380 390 400
NKAEFHQSVI SQYQVQSTPV TIQVINVQEG ISFRPPSRTF TVQRGVSINK
410 420 430 440 450
LAGYILGTYQ ATDEDTGKAA SSVRYVLGRN DGGFLVIDSK TAEIKFVKNI
460 470 480 490 500
NRDSTFIVNK TISAEVLAID ENTGKTSTGT VYVEVPSFNE NCPSVVLEKR
510 520 530 540 550
EICTSSPSVT LSVRTLDRAK YTGPYTVSLE EQPLKLPVVW TITTLNATSA
560 570 580 590 600
LLQAQQHISP GVYNVPVIVK DNQDGQCDTL ESLTLTVCQC DDRSMCRAPG
610 620 630 640 650
PSREPFIREE STWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA
660 670 680 690 700
GTGGFVPVPD GSEGTIHQWG IEGAQPEDKE ITNICVPPVT SNGADFMESS
710 720 730 740 750
EVCTNTYAGG TLVEGASGME MTTKLGGATG SGAAVALGLG HSGTMRTRHS
760 770 780 790 800
TGGTLKDYAA PVNMTFLGSY FSQKSSAYAE EEDDREVNDC LLIYDDEGED
810 820 830 840 850
AAPRSPALSS CSFMADDLDD SFLDSLGPKF KKLAEICLGV DDEAKQVKPG
860 870 880 890 900
PKDSSSGADA CARPTEALQA GSNRYQTLPG SLEVTQSGSS RYQTLPGGLE
910 920 930 940 950
VTQSGSNRYQ TLPGGLEVTQ SGSNRYQTLP GGLEVTQSGS KVCHVLPGNQ
960 970 980 990 1000
DTSVLSSSGS VHPAIAIPDP LQLGNYLLTE TYTTSGSFVQ PTTATFDPHV
1010 1020 1030 1040
TQNVTVTERV ICPLPSASGS IVAPTELRGS YSMLYTKEAC SHL
Length:1,043
Mass (Da):113,166
Last modified:July 22, 2015 - v1
Checksum:i8F51658F73DC198B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07031489 Genomic DNA No translation available.
AABR07031490 Genomic DNA No translation available.
AABR07031491 Genomic DNA No translation available.
RefSeqiXP_017456410.1, XM_017600921.1
UniGeneiRn.214863

Genome annotation databases

EnsembliENSRNOT00000091816; ENSRNOP00000072153; ENSRNOG00000016632
GeneIDi291752

Similar proteinsi

Entry informationi

Entry nameiA0A0G2K294_RAT
AccessioniPrimary (citable) accession number: A0A0G2K294
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: May 23, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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