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Protein
Submitted name:

Myosin light chain kinase

Gene

Mylk

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinaseSAAS annotation, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-445355 Smooth Muscle Contraction
R-RNO-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin light chain kinaseImported
Gene namesi
Name:MylkImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1310915 Mylk

Expressioni

Gene expression databases

BgeeiENSRNOG00000002215
ExpressionAtlasiA0A0G2K0Q7 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 122Ig-likeInterPro annotationAdd BLAST90
Domaini156 – 244Ig-likeInterPro annotationAdd BLAST89
Domaini401 – 490Ig-likeInterPro annotationAdd BLAST90
Domaini501 – 586Ig-likeInterPro annotationAdd BLAST86
Domaini604 – 698Ig-likeInterPro annotationAdd BLAST95
Domaini708 – 795Ig-likeInterPro annotationAdd BLAST88
Domaini1132 – 1220Ig-likeInterPro annotationAdd BLAST89
Domaini1272 – 1360Ig-likeInterPro annotationAdd BLAST89
Domaini1368 – 1461Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1498 – 1753Protein kinaseInterPro annotationAdd BLAST256
Domaini1843 – 1932Ig-likeInterPro annotationAdd BLAST90

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118877

Family and domain databases

CDDicd00063 FN3, 1 hit
cd14191 STKc_MLCK1, 1 hit
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR015725 MLCK1_kinase_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 9 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 9 hits
SM00408 IGc2, 9 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0G2K0Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVKLFASS HMSKTSHSVD PSRVSSLPLT EAPAFILPPR NLCVKEGATA
60 70 80 90 100
KFEGRVRGHP EPQVTWHRNG QTITNGGRFL LDGGVRGTFS LVIRGVREED
110 120 130 140 150
KGKYTCEASN GSGARQVTVE LTVEGDLMKK HGQPVLSKAS GFPGETRPSI
160 170 180 190 200
WGECPPKFAT KLGRAVVKEG QMGRFSCKIT GRPPPQVTWL KGNVPLQPSA
210 220 230 240 250
RVSMSEKNGM QILEIHEVTQ DDMGTYTCMV VNGSGKASMS AELSIPGLDN
260 270 280 290 300
ATRLSRGTKD PSPDIRKEVT NGISKDPETV AESKNCSSPQ KSNFLAQATN
310 320 330 340 350
SHLKSLQQPK LKPCEDSPRK VLQSSVLQKT SSTIVLQASK VQPEVRAAGI
360 370 380 390 400
GASGPGEERK SLTAPRQATP PTRQCGLGGS VGNKFITGNI PIENQRESRF
410 420 430 440 450
PKFESQPQSQ EVTEGQTVKF TCEVSGIPKP EVGWFLEGIP VRRQEGIVEI
460 470 480 490 500
YEDGTSHYLC LPRAGTRDSG RYSCTASNTL GQVSCSWTLR VDRPSLTQTA
510 520 530 540 550
PSFSSVLKDS VVIEGQDFVL RCSVRGTPAP QVTWLLNGQP IQFARSICEA
560 570 580 590 600
GEAELHIQDA LPEDRGTYTC LAENALGQVS CSATVTVQEK KGEGERAHRL
610 620 630 640 650
PPAPSKLFAP IFLQGLSDLK VMDGSQVTMT VQVSGNPPPE VIWLHDGNEI
660 670 680 690 700
QESEDFHFEQ KGGWHSLCIQ EVFPEDTGTY TCEAWNSAGE VRTQAILTVQ
710 720 730 740 750
EPHDGTQPWF ISKPRSVTAS LGQSVLISCA IAGDPFPTVH WLRDGKALSR
760 770 780 790 800
DHGHFELLQN EDVFTLVLKN VQPWHAGQYE ILLKNRVGEC SCQVSLMLHK
810 820 830 840 850
GPSRVPPPRG REPASCEGLC GGGVGAHGDA DRDGTLRPCW PARGQGWPEE
860 870 880 890 900
EDGEDVRGLL KRRVETRLHT EEAIRQQEVG QLDFRDLLGK KVSTKTVSED
910 920 930 940 950
DLKDIPAEQM DFRANLQRQV KPKTVSEEER KVHSPQQVDF RSVLAKKGTP
960 970 980 990 1000
KTPVPEKVPP QKAATPDFRS VLGSKKKSPA ENGGNTAEVL NVKAGESPTP
1010 1020 1030 1040 1050
AGNAQPVGAL KPIGNAKPAE TLKSVGNAKP AETLKPVGNA KPAETLKPVG
1060 1070 1080 1090 1100
NVKPAETLKP IANAQPSGSP KPIANAQPIE TQKSVANAKS AETPKLAGKE
1110 1120 1130 1140 1150
ELKEVRNDVN CKKAHVGATG NEKRPESQGS APVFKEKLQD VHVAEGEKLL
1160 1170 1180 1190 1200
LQCQVTSDPP ATVTWTLNGK TLKTTKFIIL AQEGSLFSVS IEKALPEDRG
1210 1220 1230 1240 1250
LYKCVAKNSA GQAECSCQVT VDDAGTSENT KAPEMKSRRP KSSLTPVLGT
1260 1270 1280 1290 1300
ESDATVKKKP ASKTPTKAAM PPQIIQFPED QKVRAGEPVE LFGKVTGTQP
1310 1320 1330 1340 1350
ITCTWMKFRK QIQESENIRV ENSESGSKLT ILAARQEHCG CYTLVVENKL
1360 1370 1380 1390 1400
SSRQAQVNLT VVDKPDPPAG TPCASDIRSS SLTLSWYGSS YDGGSAVQSY
1410 1420 1430 1440 1450
NVEIWDTEDK VWTELATCRS TSFNVQDLLP DREYKFRVRA VNVYGTSEPS
1460 1470 1480 1490 1500
QESELTAVGE KPEEPKDEVE VSDDDEKEPE VDYRTVTVNT EQKVSDVYDI
1510 1520 1530 1540 1550
EERLGSGKFG QVFRLVEKRT GKIWAGKFFK AYSAKEKENI RQEISIMNCL
1560 1570 1580 1590 1600
HHPKLVQCVD AFEEKANIVM VLEIVSGGEL FERIIDEDFE LTERECIKYM
1610 1620 1630 1640 1650
RQISEGVEYI HKQGIVHLDL KPENIMCVNK TGTRIKLIDF GLARRLENAG
1660 1670 1680 1690 1700
SLKVLFGTPE FVAPEVINYE PIGYATDMWS IGVICYILVS GLSPFMGDND
1710 1720 1730 1740 1750
NETLANVTSA TWDFDDEAFD EISEDAKDFI SNLLKKDMKN RLDCTQCLQH
1760 1770 1780 1790 1800
PWLMKDTKNM EAKKLSKDRM KKYMARRKWQ KTGNAVRAIG RLSSMAMISG
1810 1820 1830 1840 1850
LSGRKSSTGS PTSPINAEKL ESEEDVSQAF LEAVAEEKPH VKPYFSKTIR
1860 1870 1880 1890 1900
DLEVVEGSAA RFDCKIEGYP DPEVVWFKDD QSIRESRHFQ IDYDEDGNCS
1910 1920 1930 1940 1950
LIISDVCGDD DAKYTCKAVN SLGEATCTAE LIVETMEEGE GEEGGEEEEE

EE
Length:1,952
Mass (Da):214,003
Last modified:July 22, 2015 - v1
Checksum:i5DD78FFA1CD04D3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034408 Genomic DNA No translation available.
AABR07034409 Genomic DNA No translation available.
RefSeqiXP_006248495.1, XM_006248433.3
XP_006248496.1, XM_006248434.3
XP_017453410.1, XM_017597921.1
UniGeneiRn.203004

Genome annotation databases

EnsembliENSRNOT00000085618; ENSRNOP00000071545; ENSRNOG00000002215
GeneIDi288057

Similar proteinsi

Entry informationi

Entry nameiA0A0G2K0Q7_RAT
AccessioniPrimary (citable) accession number: A0A0G2K0Q7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: May 23, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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