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Protein
Submitted name:

Rho guanine nucleotide exchange factor 40

Gene

Arhgef40

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-193648 NRAGE signals death through JNK
R-RNO-194840 Rho GTPase cycle
R-RNO-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 40Imported
Gene namesi
Name:Arhgef40Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1308093 Arhgef40

PTM / Processingi

Proteomic databases

PaxDbiA0A0G2JZE7

Expressioni

Gene expression databases

BgeeiENSRNOG00000052354

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037837

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1082 – 1250DHInterPro annotationAdd BLAST169
Domaini1262 – 1369PHInterPro annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili688 – 708Sequence analysisAdd BLAST21
Coiled coili766 – 789Sequence analysisAdd BLAST24
Coiled coili1226 – 1246Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00920000149030
OMAiVEEEAWD

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0G2JZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY QEDALRYTLD
60 70 80 90 100
FLVPAKHLLA KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL
110 120 130 140 150
RPGDFYLQVV PSAAQAPRLA LKCLAPGGGR VQELPVPNEA CAYLFTPEWL
160 170 180 190 200
QGINKDRPTG RLSTCLLSAP SGIQRLPWAE LVCPRFVHKE GLMVGHQPST
210 220 230 240 250
LPPELPSGPP GLPSSPLPEE VLGTRSPGDG HNAPAEGPEG EYVELLEVTL
260 270 280 290 300
PVRGSPIDAE ASGLSRTRTV PARKTTGGKG RHRRHRAWMN QKGPGSRDQD
310 320 330 340 350
GTRPPGEGSS TGASSDSPSG AEADPDAAVL EAPEPPAEAS GEASESCLLS
360 370 380 390 400
GEAVGGVGQG TEGPPDTPRR TGKGNRRKKR AAGRGAVSRG GESTPLSPRD
410 420 430 440 450
KEETRQPEVL SLPSPSEQEP VECSLVKEKE DSGKPESESK EELKPADEKE
460 470 480 490 500
PAPPEDYEPP EEGNRESEKE ELPPECTAGS TGPEWFPSEP PTQPLETVQD
510 520 530 540 550
VKEDSIPEET PPVSASDDPL IVWDLMSSGF FILTGGVDQT GRALLRITPP
560 570 580 590 600
PPCLPEEPSP SQETLSTALR YLHSLLRPDL QLLGLTILLD LRKVPPLPPA
610 620 630 640 650
LLPALSQLQD SGDPPFIQRL LILTHEDPPE ELCGFQGAEL LSEKDLKRVA
660 670 680 690 700
KPEELQWDLG GHRDLSPNHW AEIHQEVARL CTLCQGVLTS VRQAIEELEG
710 720 730 740 750
AAESKEEESV GMPEPLQKVL ADPRLTALQR NGGAILMRLR STHSSKLEGP
760 770 780 790 800
GPAVLYQEVD EAIHQLVRLS NLRVQQQEQR QRLRQVQEVL QWLSGPGEEQ
810 820 830 840 850
LASFTIPGNS LSVLQETELR FRAFSTEVQE RLVQAREALA LEEDITSQKV
860 870 880 890 900
LDIFEQRLEQ VESGLHRALR LQRFFQQAHE WVDEGCARLA GAGPGREAVL
910 920 930 940 950
AALALRRAPE PSAGTFQEMR ALALDLGSPA ALREWGRCRA RCQELERRIQ
960 970 980 990 1000
QQLGEEASPR SHRRRRADSA SSAGAQHGAH SPSPSLSSLL LPSSPGPRAA
1010 1020 1030 1040 1050
PSHCSLTPCG EDYEEEGLEL APEADGRPPR AVLIRGLEVT STEVVDRTCS
1060 1070 1080 1090 1100
PREHVLLGRA GGPDGPWGIG TPRMERKRSI SAQQRLVSEL IDCEQEYITT
1110 1120 1130 1140 1150
LNEPVPPPGP ELTPGLRCTW AAALSVRERL RSFHGTHFLQ ELQGCTAHPL
1160 1170 1180 1190 1200
RIGACFLRHG DQFNLYAQFV KHRHKLESGL TALTPSVKGS MEGSPCLPRA
1210 1220 1230 1240 1250
LQQPLEQLAR YAQLLEELLR EAGPELSSER QALRAAVQLL QEQEARGRDL
1260 1270 1280 1290 1300
LAVEAVRGCE IDLREQGQLL HRDPFTVICG RKKCLRHVFL FEDLLLFSKS
1310 1320 1330 1340 1350
KGSEGGSETF VYKQAFKTAD MGLTENIGDS GLCFELWFRR RRAREAYTLQ
1360 1370 1380 1390 1400
ATSPETKLKW TSSIAQLLWR QAAHNKELRV QQMVSMGIGN KPFLDIKALG
1410 1420 1430 1440 1450
ERTLSALLTG RAARTRASVA VSSFEHAGPS LPGLSPGACS LPARVEEEAW
1460 1470 1480 1490 1500
DLDVKQISLA SETLDSSGDV SPGPRNSPSL QSPNPGSSTP ALSSGGILGL
1510
SRQSHSRALS DPTTPL
Length:1,516
Mass (Da):165,338
Last modified:July 22, 2015 - v1
Checksum:iCF93A234108AB894
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129736 Genomic DNA No translation available.
RefSeqiNP_001258242.1, NM_001271313.1
UniGeneiRn.98243

Genome annotation databases

EnsembliENSRNOT00000078475; ENSRNOP00000071018; ENSRNOG00000052354
GeneIDi361034
KEGGirno:361034

Similar proteinsi

Entry informationi

Entry nameiA0A0G2JZE7_RAT
AccessioniPrimary (citable) accession number: A0A0G2JZE7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: June 20, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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