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Protein
Submitted name:

GRB2-associated-binding protein 1

Gene

Gab1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-109704 PI3K Cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-180292 GAB1 signalosome
R-RNO-1963642 PI3K events in ERBB2 signaling
R-RNO-5654689 PI-3K cascade:FGFR1
R-RNO-5654695 PI-3K cascade:FGFR2
R-RNO-5654710 PI-3K cascade:FGFR3
R-RNO-5654720 PI-3K cascade:FGFR4
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8851907 MET activates PI3K/AKT signaling
R-RNO-8853659 RET signaling
R-RNO-8865999 MET activates PTPN11
R-RNO-8875555 MET activates RAP1 and RAC1
R-RNO-8875656 MET receptor recycling
R-RNO-9032759 NTRK2 activates RAC1

Names & Taxonomyi

Protein namesi
Submitted name:
GRB2-associated-binding protein 1Imported
Gene namesi
Name:Gab1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1311085 Gab1

Expressioni

Gene expression databases

BgeeiENSRNOG00000017879 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiA0A0G2JZD5 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 116PHInterPro annotationAdd BLAST112

Phylogenomic databases

GeneTreeiENSGT00510000046662
OMAiVNGFFQQ

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A0G2JZD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN
60 70 80 90 100
DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS
110 120 130 140 150
EEDMNKWVRC ICDICGFNPT EEDPVRPLAS SSQAPADSPF AINTAPASAH
160 170 180 190 200
MEPSSVALPP SYQLISLPPH PDTLGLREDP QDYLLLINCQ SKKPEPTSQG
210 220 230 240 250
SSLVSEEGEE YLLLEDFESK AIPLQAHFDS AKPTSSETDC NDNVPSHKPP
260 270 280 290 300
ASSQGKHGMN GFQQQMVYDC PPPRVTSVSG ESGLYNLPRS YSHDVLPKES
310 320 330 340 350
PSSTEADGEL YVFNTPSGTS SVEAQMRHVS ISYDIPPTPG NTYQVPRTFP
360 370 380 390 400
EGTLGQSSKL DTIPDVPPPR PPKPHSTHDR SPVETCGVPR TASDTDSSYC
410 420 430 440 450
IPPAGMPPSR SNTISTVDLN KLRKDAGSQD CYDIPRTFPS DRSSSLEGFH
460 470 480 490 500
NQLKIKNVLA AGNVSGEELD ENYVPMNPNS PPRHHPSSFA EPIQEPNYVP
510 520 530 540 550
MTPGTFDFSA FGMQVPPPAH LGFRSSPKTP PRRPVPVADC EPPPVDRNLK
560 570 580 590 600
PDRKVKPAPL EIKPLSEWEE LQAPVRSPIT RSFARDSSRF PMSPRPDSVH
610 620 630 640 650
STTSSSDSHD SEENYVPMNP NLSNEDQNLF CNNSLEGASS PMTKPKGDKQ
660 670 680 690 700
VEYLDLDLES GKSTPPRKQK NSGSGSSMSD ERVDYVVVDQ QKTLALKSTR
710 720
EAWTDGRQST ESETPTKNVK
Length:720
Mass (Da):79,567
Last modified:July 22, 2015 - v1
Checksum:iE0A633A9CC391FF1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZAL7D3ZAL7_RAT
GRB2-associated-binding protein 1
Gab1
693Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043601 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000083219; ENSRNOP00000071006; ENSRNOG00000017879

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043601 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083219; ENSRNOP00000071006; ENSRNOG00000017879

Organism-specific databases

RGDi1311085 Gab1

Phylogenomic databases

GeneTreeiENSGT00510000046662
OMAiVNGFFQQ

Enzyme and pathway databases

ReactomeiR-RNO-109704 PI3K Cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-180292 GAB1 signalosome
R-RNO-1963642 PI3K events in ERBB2 signaling
R-RNO-5654689 PI-3K cascade:FGFR1
R-RNO-5654695 PI-3K cascade:FGFR2
R-RNO-5654710 PI-3K cascade:FGFR3
R-RNO-5654720 PI-3K cascade:FGFR4
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8851907 MET activates PI3K/AKT signaling
R-RNO-8853659 RET signaling
R-RNO-8865999 MET activates PTPN11
R-RNO-8875555 MET activates RAP1 and RAC1
R-RNO-8875656 MET receptor recycling
R-RNO-9032759 NTRK2 activates RAC1

Gene expression databases

BgeeiENSRNOG00000017879 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiA0A0G2JZD5 baseline and differential

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0G2JZD5_RAT
AccessioniPrimary (citable) accession number: A0A0G2JZD5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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