UniProtKB - A0A0G2JXN2 (TRI46_RAT)
Tripartite motif-containing protein 46
Trim46
Functioni
Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 227 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 230 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 249 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 255 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 33 – 59 | RING-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 172 – 231 | RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 222 – 263 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
GO - Biological processi
- anterograde synaptic vesicle transport Source: RGD
- axonogenesis Source: RGD
- microtubule bundle formation Source: RGD
- microtubule cytoskeleton organization Source: RGD
- negative regulation of axon extension Source: ARUK-UCL
- neuron migration Source: RGD
- positive regulation of anterograde dense core granule transport Source: ARUK-UCL
- protein localization to axon Source: RGD
- regulation of protein localization Source: ARUK-UCL
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 46Curated |
Gene namesi | Name:Trim46Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305993, Trim46 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- axon 1 Publication
Note: Microtubule-associated. Localizes to the proximal part of the axon.1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- axon cytoplasm Source: GOC
- axon initial segment Source: RGD
- main axon Source: ARUK-UCL
- proximal neuron projection Source: RGD
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000441888 | 1 – 759 | Tripartite motif-containing protein 46Add BLAST | 759 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 330 | PhosphoserineBy similarity | 1 | |
Modified residuei | 627 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinPTM databases
iPTMneti | A0A0G2JXN2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000055433, Expressed in frontal cortex and 20 other tissues |
Interactioni
Subunit structurei
Interacts with TUBB3 and TUBA4A.
1 PublicationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 370 – 427 | COSPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 429 – 528 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 513 – 747 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 166 | Required for proximal axon localization, axon formation and migrationBy similarityAdd BLAST | 166 | |
Regioni | 67 – 98 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 411 – 429 | Required for microtubule association, proximal axon localization and axon formationBy similarityAdd BLAST | 19 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 294 – 400 | Sequence analysisAdd BLAST | 107 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 75 – 92 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 33 – 59 | RING-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 172 – 231 | RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 222 – 263 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
OMAi | LNFIQVP |
OrthoDBi | 180330at2759 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit cd12895, SPRY_PRY_TRIM46, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 2.60.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR017903, COS_domain IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR040859, Midline-1_COS IPR035731, SPRY/PRY_TRIM46 IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF18568, COS, 1 hit PF00643, zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS51262, COS, 1 hit PS50853, FN3, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH
60 70 80 90 100
NVCQACAREV LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD
110 120 130 140 150
RLDRLLKSGF GTYPGRKRGA LHPQTILFPC PACQGDVELG ERGLSGLFRN
160 170 180 190 200
LTLERVVERY RQSVSVGGAI LCQLCKPPPL EATKGCSECR ATFCNECFKL
210 220 230 240 250
FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT CQRLVCQLCR
260 270 280 290 300
VRRTHSGHKI TPVLSAYQAL KDKLTKSLAY ILGNQDTVQT QICELEETIR
310 320 330 340 350
HTEVSGQQAK EEVSQLVRGL GAVLEEKRSS LLQAIEECQQ ERLSRLSAQI
360 370 380 390 400
HEHQSLLDGS GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR
410 420 430 440 450
PAASSSFRHC QLDVGREMKL LTELNFLRVP EAPVIDTQRT FAYDQIFLCW
460 470 480 490 500
RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW QRREEVRGTS ALLENPDTGS
510 520 530 540 550
VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDGRWG ASRERLAISK
560 570 580 590 600
DQRAVRSIPG LPLLLAAERL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP
610 620 630 640 650
ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDAAVEALPP
660 670 680 690 700
FAFLTIGMGK ILLGSGASSN AGLTGRDGPA ASCTVPLPPR LGICLDYERG
710 720 730 740 750
RVSFLDAVSF RGLLECPLDC SGPVCPAFCF IGGGAVQLQE PVGTKPERKV
TIGGFAKLD
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A096MJK9 | A0A096MJK9_RAT | Tripartite motif-containing protein... | Trim46 | 112 | Annotation score: | ||
A0A5H1ZRU8 | A0A5H1ZRU8_RAT | Tripartite motif-containing protein... | Trim46 | 561 | Annotation score: | ||
A0A096MKH7 | A0A096MKH7_RAT | Tripartite motif-containing protein... | Trim46 | 354 | Annotation score: | ||
A0A096MKD5 | A0A096MKD5_RAT | Tripartite motif-containing protein... | Trim46 | 285 | Annotation score: | ||
A0A5H1ZRV2 | A0A5H1ZRV2_RAT | Tripartite motif-containing protein... | Trim46 | 373 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098750 Genomic DNA No translation available. CH473976 Genomic DNA Translation: EDM00656.1 Sequence problems. |
RefSeqi | NP_001101161.1, NM_001107691.1 XP_008759392.1, XM_008761170.2 |
Genome annotation databases
GeneIDi | 310641 |
KEGGi | rno:310641 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC098750 Genomic DNA No translation available. CH473976 Genomic DNA Translation: EDM00656.1 Sequence problems. |
RefSeqi | NP_001101161.1, NM_001107691.1 XP_008759392.1, XM_008761170.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
iPTMneti | A0A0G2JXN2 |
Genome annotation databases
GeneIDi | 310641 |
KEGGi | rno:310641 |
Organism-specific databases
CTDi | 80128 |
RGDi | 1305993, Trim46 |
Phylogenomic databases
OMAi | LNFIQVP |
OrthoDBi | 180330at2759 |
Miscellaneous databases
PROi | PR:A0A0G2JXN2 |
Gene expression databases
Bgeei | ENSRNOG00000055433, Expressed in frontal cortex and 20 other tissues |
Family and domain databases
CDDi | cd00063, FN3, 1 hit cd12895, SPRY_PRY_TRIM46, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 2.60.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR013320, ConA-like_dom_sf IPR017903, COS_domain IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR040859, Midline-1_COS IPR035731, SPRY/PRY_TRIM46 IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF18568, COS, 1 hit PF00643, zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS51262, COS, 1 hit PS50853, FN3, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI46_RAT | |
Accessioni | A0A0G2JXN2Primary (citable) accession number: A0A0G2JXN2 Secondary accession number(s): A0A096MKD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2017 |
Last sequence update: | October 25, 2017 | |
Last modified: | February 23, 2022 | |
This is version 45 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families