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UniProtKB - A0A0G2JWH3 (A0A0G2JWH3_RAT)

Entry version 35 (07 Oct 2020)
Sequence version 1 (22 Jul 2015)
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Protein

Condensin complex subunit 1

Gene

Ncapd2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA condensationUniRule annotationARBA annotation, MitosisUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-2514853, Condensation of Prometaphase Chromosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Condensin complex subunit 1UniRule annotationARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncapd2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...RGDi		1562596, Ncapd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0A0G2JWH3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A0A0G2JWH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000055300, Expressed in thymus and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000025889

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A0G2JWH3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini77 – 240Cnd1_NInterPro annotationAdd BLAST164
Domaini1059 – 1218Cnd1InterPro annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni569 – 601DisorderedSequence analysisAdd BLAST33
Regioni944 – 965DisorderedSequence analysisAdd BLAST22
Regioni1289 – 1389DisorderedSequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi944 – 963PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1296 – 1324PolarSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CND1 (condensin subunit 1) family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0414, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153566

Identification of Orthologs from Complete Genome Data

More...OMAi		RNCVLQI

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026971, CND1/NCAPD3
IPR032682, Cnd1_C
IPR007673, Condensin_cplx_su1
IPR024324, Condensin_cplx_su1_N

The PANTHER Classification System

More...PANTHERi		PTHR14222, PTHR14222, 1 hit
PTHR14222:SF2, PTHR14222:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12717, Cnd1, 1 hit
PF12922, Cnd1_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF017127, Condensin_D2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0G2JWH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPHNFEFHL PLSPEELLKS RGVNQYVVQE VLPIKHLPTQ LRAFQSAFRA 
        60         70         80         90        100
QGPLAILDHF DTIYSIIHHF RSIEPGLKED TLEFLMKVVS CHSQELSSIL 
       110        120        130        140        150
DDAALSGSDR SAHLNALKMN CYALIRLLES FENMTSQTGL IDLDIGGKGK 
       160        170        180        190        200
KARAKTALGF VWEEERQPVL ELLTQLLQLD IRHLWSHSVI EEEFVSLVTG 
       210        220        230        240        250
CCYRLLENPT ISHQKNRSTK EAIAHLLGVA LVRYNHMLSA TVKIIQMLQH 
       260        270        280        290        300
FEHLPSVLVA AVTLWATDYG MKSIVGEIVR EIGQKCPQEM SRDTAGAKGF 
       310        320        330        340        350
AAFLTELAER IPAALMSSMC MLLDHLDGEN YMMRNAVLAA MAEMILQVLN 
       360        370        380        390        400
GDQLEESARE TRDQFLDILQ AHGHDVNSFV RSRVLQLFTR IVQQKALPLT 
       410        420        430        440        450
RFQAVVALAV GRLADKSVLV CKNAIQLLAS FLANNPFSCK LSDTDLAGPL 
       460        470        480        490        500
QKEIQKLQEM RAQRRTAAAS AALDSEEEWE AMLPELKSTV QQLLKLPQEE 
       510        520        530        540        550
AEQQIADGET AEEVKGRIHQ LLARASYKQA ILLTREATSR FQESEPFSHT 
       560        570        580        590        600
EPEEKDFLNL LGVIFKGPEA STHESPRHTD PGLTGSKDSP SVPEPEGSQR 
       610        620        630        640        650
DDELLKQEML VQYLQDAYSF SQKITEAIGV ISKMMYENTT TVVQEVIEFF 
       660        670        680        690        700
VMVFQFGVPQ ALFGVRRMLP LIWSKELGVR EAVLNAYRQL YLSPKGDSAR 
       710        720        730        740        750
ATAQALIQNL SLLLVDASVG TIQCLEEILC EFVQKDEIKP AVIQLLWERA 
       760        770        780        790        800
TEKVPCSPLE RCSSVMLLGM MARGKPEIVG SNLDTLVKVG LDEKFPQDYR 
       810        820        830        840        850
LAQQVCLAIA NISDRRKPSL GERHPPFRLP QEHKLFERLQ EMVTKGFAHP 
       860        870        880        890        900
DPFWIPFKEV AVTLTYLAEG PDVICSQMLQ GCAKQALEKL EKNTTEGDSK 
       910        920        930        940        950
ETAPKLPTFL LMNLLSLAGD VALQQLVHLE QAVSGELGRR RVLREEQEHR 
       960        970        980        990       1000
TKVPKEKTTS SETTMEEELG LVGATADDTE AELVRSICEK ELLDGTQVLA 
      1010       1020       1030       1040       1050
AFVPLLLKVC NNPGAYSNPE LSAAASLALG KFCMISAPFC DSQLRLLFTM 
      1060       1070       1080       1090       1100
LEKSSLPTVR SNLMVATGDL AIRFPNLVDP WTPHLYARLR DPAQQVRRTA 
      1110       1120       1130       1140       1150
GLVMTHLILK DMVKVKGQVS EMAVLLIDPV PQIAALAKNF FNELSHKGNA 
      1160       1170       1180       1190       1200
IYNLLPDIIS RLSDPEGGVG EEPFHTIMKQ LLSYITKDKQ TESLVEKLCQ 
      1210       1220       1230       1240       1250
RFRTARTERQ YRDLAYCVSQ LPLTERGLHK MLDNFDCFGD KLIDESVFSA 
      1260       1270       1280       1290       1300
FLSIVGKLRR GAKPEGKAVI DEFEQKLRAC HTRGMDGIEE LETGQGGSQR 
      1310       1320       1330       1340       1350
ALSAKKPSAV SRQQPLTSVD SDNDFVTPKP RRTKPRRPQT QQRKSQRKAK 
      1360       1370       1380 
VVFSSDESSE DELSAEMTEE ETPKKTTPIR RASAQRHRS
Length:1,389
Mass (Da):155,462
Last modified:July 22, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBAAB21E830CD275
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07073073 Genomic DNA No translation available.
AC115415 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000083016; ENSRNOP00000069882; ENSRNOG00000055300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073073 Genomic DNA No translation available.
AC115415 Genomic DNA No translation available.

3D structure databases

SMRiA0A0G2JWH3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025889

Proteomic databases

jPOSTiA0A0G2JWH3
PaxDbiA0A0G2JWH3

Genome annotation databases

EnsembliENSRNOT00000083016; ENSRNOP00000069882; ENSRNOG00000055300

Organism-specific databases

RGDi1562596, Ncapd2

Phylogenomic databases

eggNOGiKOG0414, Eukaryota
GeneTreeiENSGT00940000153566
OMAiRNCVLQI

Enzyme and pathway databases

ReactomeiR-RNO-2514853, Condensation of Prometaphase Chromosomes

Gene expression databases

BgeeiENSRNOG00000055300, Expressed in thymus and 20 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026971, CND1/NCAPD3
IPR032682, Cnd1_C
IPR007673, Condensin_cplx_su1
IPR024324, Condensin_cplx_su1_N
PANTHERiPTHR14222, PTHR14222, 1 hit
PTHR14222:SF2, PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717, Cnd1, 1 hit
PF12922, Cnd1_N, 1 hit
PIRSFiPIRSF017127, Condensin_D2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0G2JWH3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0G2JWH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: October 7, 2020
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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