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Entry version 49 (10 Feb 2021)
Sequence version 1 (22 Jul 2015)
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Protein
Submitted name:

Collagen type XV alpha 1 chain

Gene

Col15a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1442490, Collagen degradation
R-RNO-1650814, Collagen biosynthesis and modifying enzymes
R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures
R-RNO-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type XV alpha 1 chainImported
Submitted name:
Procollagen, type XV, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col15a1Imported
Synonyms:LOC100909752Imported
ORF Names:rCG_54988Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
1310820, Col15a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501402451732 – 1345Sequence analysisAdd BLAST1314

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000060381, Expressed in heart and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000017217

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0G2JV12

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 228LAM_G_DOMAINInterPro annotationAdd BLAST189
Domaini89 – 227LAM_G_DOMAINInterPro annotationAdd BLAST139

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni269 – 321DisorderedSequence analysisAdd BLAST53
Regioni405 – 435DisorderedSequence analysisAdd BLAST31
Regioni504 – 760DisorderedSequence analysisAdd BLAST257
Regioni801 – 830DisorderedSequence analysisAdd BLAST30
Regioni847 – 867DisorderedSequence analysisAdd BLAST21
Regioni953 – 977DisorderedSequence analysisAdd BLAST25
Regioni1041 – 1063DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi305 – 320PolarSequence analysisAdd BLAST16
Compositional biasi407 – 422PolarSequence analysisAdd BLAST16
Compositional biasi583 – 597Pro-richSequence analysisAdd BLAST15
Compositional biasi680 – 696Pro-richSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

CollagenImportedARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158302

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDQCEDD

Database of Orthologous Groups

More...
OrthoDBi
1362001at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247, Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391, Collagen, 4 hits
PF06482, Endostatin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00282, LamG, 1 hit
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0G2JV12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHRRTAQGR RPRWLLSIIS TLLSTVLQTR AATGSASQDH LDLTELIGVP
60 70 80 90 100
LPSSVSFVTG YGGFPAYSFR PGANVGRPAR TLIPSTFFRD FAIGVAVKPS
110 120 130 140 150
SAQGGVLFAV TDAFQKVIYL GLRLSRVEDG RQRVILYYTE PGSHVSQEAA
160 170 180 190 200
AFSVPVMTNR WNRFAVTVQG EEAVLFMDCE EHSQVLFQRS SRPLTFEPSA
210 220 230 240 250
GIFVGNAGAT GLERFTGSIQ QLIIYSDPRT PEELCEAQES SASGEASGFQ
260 270 280 290 300
EMDEVAEIME AVTYTQAPPK EAHVDPISMP PTSSSPTEDT ELSGEPVPEG
310 320 330 340 350
TPGTDLSITG HSSPEQGSGE ILNDTLEVRT VDGNPSTDGG SGDGALLNVT
360 370 380 390 400
DGQGLSATAT GETRVPVTTA LEVENGSMPT GSPTLAMFTQ SFREVDMLDL
410 420 430 440 450
ENLTTASGDG EVPTSTDVDT EAGTLPTGGP TLKPREEATL GSLGEEWSTT
460 470 480 490 500
VVSKVPLNAF EEEEASGTAI DSLDAFTPTV VLEQASGTPT DIQAALTTTV
510 520 530 540 550
APEQVFTAAP TDGEDLVTST EESDEEGSGS TLPIGPPLSK PTVTPERQVT
560 570 580 590 600
LAGVEAEGSD PVWGVDVGSG SGDIVGNEDL LRGPPGPPGP PGSPGIPGKP
610 620 630 640 650
GTDVFVGPPG SPGEDGAPGE PGPQGPEGQP GLDGASGQPG MKGEKGARGP
660 670 680 690 700
NGSVGEKGDP GSRGLPGPPG KNGEVGIPGA MGPPGPPGPP GPPGPGCTTK
710 720 730 740 750
LGFEIEGSGD TQLLSKPRIS GPSSPSGPKG EKGEQGAKGE RGTDGISTMG
760 770 780 790 800
PPGPRGPPGR VEVLSSSLIN ITNGSMNFSD IPELMGPPGP DGVPGLPGFP
810 820 830 840 850
GPRGPKGDTG VPGFPGLKGE QGEKGEPGAI LTGDIPLEMV KGRKGEPGVH
860 870 880 890 900
GAPGPMGPKG PPGHKGEFGL PGRPGRPGLN GLKGAKGDRG IMLPGPPGLP
910 920 930 940 950
GPPGPPGPPG AVVNIKGAVF PIPARPHCKT PVGTAHPGDP ELVTFHGVKG
960 970 980 990 1000
EKGSWGLPGT KGEKGDQGAQ GPPGPPVDPA YLRHFLNSLK GENGDAAFRG
1010 1020 1030 1040 1050
ESSHNLFVSG PPGLPGHPGL AGQKGEAVVG PQGPPGIPGL PGPPGFGRPG
1060 1070 1080 1090 1100
VPGPPGPPGP PGPPAILGAA VPLPGPPGPP GQPGLPGSRN LVTALSDMGD
1110 1120 1130 1140 1150
MLQKAHLVIE GTFIYLRESG EFFLRVRDGW KKLQLGELIP IPADSPPPPA
1160 1170 1180 1190 1200
LSSNPYQPQP PLNPILSANY ERPVLHLVAL NTPVAGDIRA DFQCFQQARA
1210 1220 1230 1240 1250
AGLLSTFRAF LSSHLQDLST VVRKAERFSL PIVNLKGQVL FNNWDSIFSG
1260 1270 1280 1290 1300
DGGQFNTHIP IYSFDGRDVM TDPSWPQKVV WHGSNPHGVR LVDKYCEAWR
1310 1320 1330 1340
TTDMAVTGFA SPLSTGKILD QKAYSCANRL IVLCIENSFM TDARK
Length:1,345
Mass (Da):138,267
Last modified:July 22, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55816D8595127A8D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07048114 Genomic DNA No translation available.
AABR07048115 Genomic DNA No translation available.
AABR07048116 Genomic DNA No translation available.
CH473962 Genomic DNA Translation: EDL98855.1

NCBI Reference Sequences

More...
RefSeqi
NP_001094005.1, NM_001100535.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000088385; ENSRNOP00000069309; ENSRNOG00000060381

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
298069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:298069

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07048114 Genomic DNA No translation available.
AABR07048115 Genomic DNA No translation available.
AABR07048116 Genomic DNA No translation available.
CH473962 Genomic DNA Translation: EDL98855.1
RefSeqiNP_001094005.1, NM_001100535.1

3D structure databases

SMRiA0A0G2JV12
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017217

Genome annotation databases

EnsembliENSRNOT00000088385; ENSRNOP00000069309; ENSRNOG00000060381
GeneIDi298069
KEGGirno:298069

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1306
RGDi1310820, Col15a1

Phylogenomic databases

eggNOGiKOG3546, Eukaryota
GeneTreeiENSGT00940000158302
OMAiEDQCEDD
OrthoDBi1362001at2759

Enzyme and pathway databases

ReactomeiR-RNO-1442490, Collagen degradation
R-RNO-1650814, Collagen biosynthesis and modifying enzymes
R-RNO-2022090, Assembly of collagen fibrils and other multimeric structures
R-RNO-8948216, Collagen chain trimerization

Gene expression databases

BgeeiENSRNOG00000060381, Expressed in heart and 21 other tissues

Family and domain databases

CDDicd00247, Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR008160, Collagen
IPR010515, Collagenase_NC10/endostatin
IPR013320, ConA-like_dom_sf
IPR016187, CTDL_fold
IPR001791, Laminin_G
PfamiView protein in Pfam
PF01391, Collagen, 4 hits
PF06482, Endostatin, 2 hits
SMARTiView protein in SMART
SM00282, LamG, 1 hit
SM00210, TSPN, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF56436, SSF56436, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0G2JV12_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0G2JV12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: February 10, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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