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Protein

Mast/stem cell growth factor receptor

Gene

Kit

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi566MagnesiumUniRule annotation1
Binding sitei621ATPUniRule annotation1
Binding sitei793ATPUniRule annotation1
Metal bindingi794MagnesiumUniRule annotation1
Metal bindingi807MagnesiumUniRule annotation1
Sitei933Important for interaction with phosphotyrosine-binding proteinsUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi594 – 601ATPUniRule annotation8
Nucleotide bindingi669 – 675ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1257604 PIP3 activates AKT signaling
R-RNO-1433557 Signaling by SCF-KIT
R-RNO-1433559 Regulation of KIT signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mast/stem cell growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:KitImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620568 Kit

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei523 – 546HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_501183615726 – 974Mast/stem cell growth factor receptorUniRule annotationAdd BLAST949

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000002227 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiA0A0G2JTL4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0G2JTL4
SMRiA0A0G2JTL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 97Ig-likeInterPro annotationAdd BLAST61
Domaini212 – 310Ig-likeInterPro annotationAdd BLAST99
Domaini587 – 934Protein kinaseInterPro annotationAdd BLAST348

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR027263 SCGF_receptor
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF500951 SCGF_recepter, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 4 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A0A0G2JTL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGARGAWDL LCVLLVLLRG QTGTSQPSAS PGEPSPPSIQ PAQSELIVEA
60 70 80 90 100
GDTIRLTCTD PAFVKWTFEI LDVRIENKQS EWIREKAEAT HTGKYTCVSG
110 120 130 140 150
SGLRSSIYVF VRDPAVLFLV GLPLFGKEDN DALVRCPLTD PQVSNYSLIE
160 170 180 190 200
CDGKSLPTDL KFVPNPKAGI TIKNVKRAYH RLCIRCAAQR EGKWMRSDKF
210 220 230 240 250
TLKVRAAIKA IPVVSVPETS HLLKEGDTFT VICTIKDVST SVDSMWIKLN
260 270 280 290 300
PQPQSKAQVK RNSWHQGDFN YERQETLTIS SARVNDSGVF MCYANNTFGS
310 320 330 340 350
ANVTTTLKVV EKGFINIFPV KNTTVFVTDG ENVDLVVEFE AYPKPEHQQW
360 370 380 390 400
IYMNRTPTNR GEDYVKSDNQ SNIRYVNELR LTRLKGTEGG TYTFLVSNSD
410 420 430 440 450
VSASVTFDVY VNTKPEILTY DRLMNGRLQC VAAGFPEPTI DWYFCTGAEQ
460 470 480 490 500
RCTVPVPPVD VQIQNASVSP FGKLVVQSSI DSSVFRHNGT VECKASNAVG
510 520 530 540 550
KSSAFFNFAF KEQIQPHTLF TPLLIGFVVT AGLMGIIVMV LAYKYLQKPM
560 570 580 590 600
YEVQWKVVEE INGNNYVYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK
610 620 630 640 650
VVEATAYGLI KSDAAMTVAV KMLKPSAHLT EREALMSELK VLSYLGNHMN
660 670 680 690 700
IVNLLGACTV GGPTLVITEY CCYGDLLNFL RRKRDSFIFS KQEEQADAAL
710 720 730 740 750
YKNLLHSKES SCDSSNEYMD MKPGVSYVVP TKTDKRRSAR IDSYIERDVT
760 770 780 790 800
PAIMEDDELA LDLEDLLSFS YQVAKGMAFL ASKNCIHRDL AARNILLTHG
810 820 830 840 850
RITKICDFGL ARDIRNDSNY VVKGNARLPV KWMAPESIFN CVYTFESDVW
860 870 880 890 900
SYGIFLWELF SLGSSPYPGM PVDSKFYKMI KEGFRMLSPE HAPAAMYEVM
910 920 930 940 950
KTCWDADPLK RPTFKQVVQL IEKQISDSSK HIYSNLANCN PNPENPVVVD
960 970
HSVRVNSVGS STSSTQPLLV HEDA
Length:974
Mass (Da):108,956
Last modified:July 22, 2015 - v1
Checksum:iB9BFAD9BA0DA190D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q63116Q63116_RAT
Mast/stem cell growth factor recept...
Kit KIT, rCG_56893
978Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014877 Genomic DNA No translation available.
AABR07014878 Genomic DNA No translation available.
AABR07014879 Genomic DNA No translation available.
RefSeqiXP_006250971.1, XM_006250909.3
UniGeneiRn.54004

Genome annotation databases

EnsembliENSRNOT00000090654; ENSRNOP00000068756; ENSRNOG00000002227
GeneIDi64030

Similar proteinsi

Entry informationi

Entry nameiA0A0G2JTL4_RAT
AccessioniPrimary (citable) accession number: A0A0G2JTL4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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