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Protein
Submitted name:

MARVEL domain-containing protein 2

Gene

MARVELD2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
MARVEL domain-containing protein 2Imported
Gene namesi
Name:MARVELD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26401 MARVELD2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei192 – 215HelicalSequence analysisAdd BLAST24
Transmembranei255 – 279HelicalSequence analysisAdd BLAST25
Transmembranei291 – 312HelicalSequence analysisAdd BLAST22
Transmembranei342 – 366HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0G2JN23

Structurei

3D structure databases

ProteinModelPortaliA0A0G2JN23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 367MARVELInterPro annotationAdd BLAST180

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili162 – 182Sequence analysisAdd BLAST21
Coiled coili469 – 489Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR031176 ELL/occludin
IPR008253 Marvel
IPR031177 MARVELD2
IPR010844 Occludin_ELL
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF3 PTHR23288:SF3, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PF07303 Occludin_ELL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A0G2JN23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNDGRSRNR DRRYDEVPSD LPYQDTTIRT HPILHDSERA VSADPLPPPP
60 70 80 90 100
LPLQPPFGPD FYSSDTEEPA IAPDLKPVRR FVPDSWKNFF RGKKKDPEWD
110 120 130 140 150
KPVSDIRYIS DGVECSPPAS PARPNHRSPL NSCKDPYGGS EGTFSSRKEA
160 170 180 190 200
DAVFPRDPYG SLDRHTQTVR TYSEKVEEYN LRYSYMKSWA GLLRILGVVE
210 220 230 240 250
LLLGAGVFAC VTAYIHKDSE WYNLFGYSQP YGMGGVGGLG SMYGGYYYTG
260 270 280 290 300
PKTPFVLVVA GLAWITTIII LVLGMSMYYR TILLDSNWWP LTEFGINVAL
310 320 330 340 350
FILYMAAAIV YVNDTNRGGL CYYPLFNTPV NAVFCRVEGG QIAAMIFLFV
360 370 380 390 400
TMIVYLISAL VCLKLWRHEA ARRHREYMEQ QEINEPSLSS KRKMCEMATS
410 420 430 440 450
GDRQRDSEVN FKELRTAKMK PELLSGHIPP GHIPKPIVMP DYVAKYPVIQ
460 470 480 490 500
TDDERERYKA VFQDQFSEYK ELSAEVQAVL RKFDELDAVM SRLPHHSESR
510
QEHERISRIH EEFKKK
Length:516
Mass (Da):59,008
Last modified:July 22, 2015 - v1
Checksum:iE14638E218B282B2
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N4S9MALD2_HUMAN
MARVEL domain-containing protein 2
MARVELD2 TRIC
558Annotation score:
A1BQX2A1BQX2_HUMAN
MARVEL domain-containing protein 2
MARVELD2
442Annotation score:
D6RA09D6RA09_HUMAN
MARVEL domain-containing protein 2
MARVELD2
516Annotation score:
A0A0G2JQ38A0A0G2JQ38_HUMAN
MARVEL domain-containing protein 2
MARVELD2
442Annotation score:
D6RAH8D6RAH8_HUMAN
MARVEL domain-containing protein 2
MARVELD2
145Annotation score:
A0A0G2JN00A0A0G2JN00_HUMAN
MARVEL domain-containing protein 2
MARVELD2
145Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei516Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC144587 Genomic DNA No translation available.
AC145145 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000622563; ENSP00000480479; ENSG00000274671

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC144587 Genomic DNA No translation available.
AC145145 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A0G2JN23
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0G2JN23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622563; ENSP00000480479; ENSG00000274671

Organism-specific databases

HGNCiHGNC:26401 MARVELD2
GenAtlasiSearch...

Miscellaneous databases

ChiTaRSiMARVELD2 human

Family and domain databases

InterProiView protein in InterPro
IPR031176 ELL/occludin
IPR008253 Marvel
IPR031177 MARVELD2
IPR010844 Occludin_ELL
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF3 PTHR23288:SF3, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PF07303 Occludin_ELL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0G2JN23_HUMAN
AccessioniPrimary (citable) accession number: A0A0G2JN23
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: May 23, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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