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UniProtKB - A0A0G2JH35 (A0A0G2JH35_HUMAN)
Protein
Submitted name:
Potassium voltage-gated channel subfamily KQT member 2
Gene
KCNQ2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channelARBA annotation, Voltage-gated channelARBA annotation |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Names & Taxonomyi
Protein namesi | Submitted name: Potassium voltage-gated channel subfamily KQT member 2 |
Gene namesi | Name:KCNQ2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6296, KCNQ2 |
VEuPathDBi | HostDB:ENSG00000075043 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- voltage-gated potassium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 33 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 54 – 73 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 120 – 138 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 179 – 204 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotation, Ubl conjugationARBA annotationProteomic databases
PeptideAtlasi | A0A0G2JH35 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075043, Expressed in right hemisphere of cerebellum and 129 other tissues |
ExpressionAtlasi | A0A0G2JH35, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 204 | Ion_transInterPro annotationAdd BLAST | 195 | |
Domaini | 322 – 506 | KCNQ_channelInterPro annotationAdd BLAST | 185 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 288 – 344 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 454 – 475 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 515 – 536 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 549 – 613 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 694 – 728 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 315 – 335 | Polar residuesSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160093 |
Family and domain databases
InterProi | View protein in InterPro IPR020969, Ankyrin-G_BS IPR005821, Ion_trans_dom IPR003937, K_chnl_volt-dep_KCNQ IPR003947, K_chnl_volt-dep_KCNQ2 IPR013821, K_chnl_volt-dep_KCNQ_C IPR028325, VG_K_chnl |
PANTHERi | PTHR11537, PTHR11537, 1 hit PTHR11537:SF6, PTHR11537:SF6, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF03520, KCNQ_channel, 1 hit PF11956, KCNQC3-Ank-G_bd, 1 hit |
PRINTSi | PR01459, KCNQCHANNEL |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
A0A0G2JH35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IKEYEKSSEG ALYILEIVTI VVFGVEYFVR IWAAGCCCRY RGWRGRLKFA
60 70 80 90 100
RKPFCVIDIM VLIASIAVLA AGSQGNVFAT SALRSLRFLQ ILRMIRMDRR
110 120 130 140 150
GGTWKLLGSV VYAHSKELVT AWYIGFLCLI LASFLVYLAE KGENDHFDTY
160 170 180 190 200
ADALWWGLIT LTTIGYGDKY PQTWNGRLLA ATFTLIGVSF FALPAGILGS
210 220 230 240 250
GFALKVQEQH RQKHFEKRRN PAAGLIQSAW RFYATNLSRT DLHSTWQYYE
260 270 280 290 300
RTVTVPMYSS QTQTYGASRL IPPLNQLELL RNLKSKSGLA FRKDPPPEPS
310 320 330 340 350
PSPRGVAAKG KGSPQAQTVR RSPSADQSLE DSPSKVPKSW SFGDRSRARQ
360 370 380 390 400
AFRIKGAASR QNSEEASLPG EDIVDDKSCP CEFVTEDLTP GLKVSIRAVC
410 420 430 440 450
VMRFLVSKRK FKESLRPYDV MDVIEQYSAG HLDMLSRIKS LQSRVDQIVG
460 470 480 490 500
RGPAITDKDR TKGPAEAELP EDPSMMGRLG KVEKQVLSME KKLDFLVNIY
510 520 530 540 550
MQRMGIPPTE TEAYFGAKEP EPAPPYHSPE DSREHVDRHG CIVKIVRSSS
560 570 580 590 600
STGQKNFSAP PAAPPVQCPP STSWQPQSHP RQGHGTSPVG DHGSLVRIPP
610 620 630 640 650
PPAHERSLSA YGGGNRASME FLRQEDTPGC RPPEGNLRDS DTSISIPSVD
660 670 680 690 700
HEELERSFSG FSISQSKENL DALNSCYAAV APCAKVRPYI AEGESDTDSD
710 720
LCTPCGPPPR SATGEGPFGD VGWAGPRK
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO43526 | KCNQ2_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 872 | Annotation score: | ||
A0A1B0GW14 | A0A1B0GW14_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 671 | Annotation score: | ||
A0A0G2JQC9 | A0A0G2JQC9_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 380 | Annotation score: | ||
A0A0G2JQG6 | A0A0G2JQG6_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 370 | Annotation score: | ||
A0A0G2JR54 | A0A0G2JR54_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 410 | Annotation score: | ||
A0A0G2JRU6 | A0A0G2JRU6_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 392 | Annotation score: | ||
A0A0G2JRN9 | A0A0G2JRN9_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 382 | Annotation score: | ||
Q4VXP6 | Q4VXP6_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 766 | Annotation score: | ||
A0A0D9SEV1 | A0A0D9SEV1_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 754 | Annotation score: | ||
A0A0D9SF10 | A0A0D9SF10_HUMAN | Potassium voltage-gated channel sub... | KCNQ2 | 645 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121827 Genomic DNA No translation available. AL121829 Genomic DNA No translation available. AL353658 Genomic DNA No translation available. KF456987 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000357249.6; ENSP00000349789.3; ENSG00000075043.20 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121827 Genomic DNA No translation available. AL121829 Genomic DNA No translation available. AL353658 Genomic DNA No translation available. KF456987 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0G2JH35 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A0G2JH35 |
Protocols and materials databases
Antibodypediai | 15101, 285 antibodies from 31 providers |
Genome annotation databases
Ensembli | ENST00000357249.6; ENSP00000349789.3; ENSG00000075043.20 |
Organism-specific databases
HGNCi | HGNC:6296, KCNQ2 |
OpenTargetsi | ENSG00000075043 |
VEuPathDBi | HostDB:ENSG00000075043 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160093 |
Miscellaneous databases
ChiTaRSi | KCNQ2, human |
Gene expression databases
Bgeei | ENSG00000075043, Expressed in right hemisphere of cerebellum and 129 other tissues |
ExpressionAtlasi | A0A0G2JH35, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR020969, Ankyrin-G_BS IPR005821, Ion_trans_dom IPR003937, K_chnl_volt-dep_KCNQ IPR003947, K_chnl_volt-dep_KCNQ2 IPR013821, K_chnl_volt-dep_KCNQ_C IPR028325, VG_K_chnl |
PANTHERi | PTHR11537, PTHR11537, 1 hit PTHR11537:SF6, PTHR11537:SF6, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF03520, KCNQ_channel, 1 hit PF11956, KCNQC3-Ank-G_bd, 1 hit |
PRINTSi | PR01459, KCNQCHANNEL |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0G2JH35_HUMAN | |
Accessioni | A0A0G2JH35Primary (citable) accession number: A0A0G2JH35 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 22, 2015 |
Last sequence update: | July 22, 2015 | |
Last modified: | May 25, 2022 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |