Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 26 (02 Jun 2021)
Sequence version 1 (22 Jul 2015)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Histone-lysine N-methyltransferase SETD2

Gene

Setd2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Histone-lysine N-methyltransferase SETD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Setd2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918177, Setd2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A0G2JH06

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
324753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044791, Expressed in undifferentiated genital tubercle and 264 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0G2JH06, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1185 – 1239AWSInterPro annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 198DisorderedSequence analysisAdd BLAST198
Regioni246 – 269DisorderedSequence analysisAdd BLAST24
Regioni317 – 346DisorderedSequence analysisAdd BLAST30
Regioni546 – 611DisorderedSequence analysisAdd BLAST66
Regioni657 – 691DisorderedSequence analysisAdd BLAST35
Regioni716 – 793DisorderedSequence analysisAdd BLAST78
Regioni835 – 923DisorderedSequence analysisAdd BLAST89
Regioni949 – 974DisorderedSequence analysisAdd BLAST26
Regioni988 – 1063DisorderedSequence analysisAdd BLAST76
Regioni1083 – 1119DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi16 – 45Polar residuesSequence analysisAdd BLAST30
Compositional biasi58 – 129Basic and acidic residuesSequence analysisAdd BLAST72
Compositional biasi142 – 196Basic and acidic residuesSequence analysisAdd BLAST55
Compositional biasi326 – 344Polar residuesSequence analysisAdd BLAST19
Compositional biasi546 – 561Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi562 – 577Polar residuesSequence analysisAdd BLAST16
Compositional biasi587 – 611Polar residuesSequence analysisAdd BLAST25
Compositional biasi664 – 691Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi716 – 743Polar residuesSequence analysisAdd BLAST28
Compositional biasi757 – 790Polar residuesSequence analysisAdd BLAST34
Compositional biasi856 – 870Polar residuesSequence analysisAdd BLAST15
Compositional biasi871 – 885Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi905 – 923Polar residuesSequence analysisAdd BLAST19
Compositional biasi1020 – 1037Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1038 – 1063Polar residuesSequence analysisAdd BLAST26

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160086

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006560, AWS_dom
IPR042294, SETD2_animal

The PANTHER Classification System

More...
PANTHERi
PTHR46711, PTHR46711, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17907, AWS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00570, AWS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51215, AWS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A0G2JH06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XSHIGKEEEV SDGSKISLSS KKASSKKKSS QFEGTFLGSE SDEDSVRTSS
60 70 80 90 100
SQRSHDLKSS TSIDKERDFK KSSAPSKSED LGKSSRSKTE RDDRYCSYSK
110 120 130 140 150
LERDTRYVSS RCRSERDRRR SRSRSRSDRA SRTSLSYSRS ERSHYYDSER
160 170 180 190 200
RYHRSSPYRE RTRYSRPYTD NRARESSDSE DEYKKTYPRR TSAHSYRDLR
210 220 230 240 250
TSSSYSKFDR DCKTETSYLE MERRGKYTSK LERESKRTSE HETIKRCCSP
260 270 280 290 300
PNELGFRRGS SYSKHDNSTS RYKSALSKSI SKNDKFKNSF CCTELNEENK
310 320 330 340 350
QSHSFSLQTP CSKGSELRTI NKISEREKTG SPTPSNQLND SPTFKKLDES
360 370 380 390 400
PVLKPEFIGH DGRESIKELE LSKVKNDQLR NFCSIELNVN GSPETEADVA
410 420 430 440 450
TFCTSKTDAI SMTSDDSVTG SEVSPLIKAC MLSSNGFQNV GRCRERDSDD
460 470 480 490 500
TCRQHNTSKS PFREMEPLLS PHHDKLMSLP VKTIDYPKTL IKEPVDKRHS
510 520 530 540 550
CCKTKDSDIY CSPNENPEAE NAEPSAMTIS SHSFVNVHLE SKTVICDNRE
560 570 580 590 600
PTDRHSENTC DEYKQSIGST SSASHNHFDG LYEPIGSSGI SSLQSPPSGI
610 620 630 640 650
RCEENTSPTL DAVESKKGID FLKYARKETD VGSALPDSGK GFSWENRHNN
660 670 680 690 700
VLSGQSLQEA QEEGNSILHE RRGRPEIPLD EEQRGHTHIS DDSEVVFPYD
710 720 730 740 750
LNLTMEDSDG ITYTLKCDSS GNAPEIVSTV HEDYSGSSAS SSDESDSEDT
760 770 780 790 800
ESDDSSIPRN RLQSVVVVPK NSTLPMEETS PCSSRSSQSY KHYSDRWEDG
810 820 830 840 850
LETRRHAYEE EYESKGCSQT EKYFLHKGTE RSAESCYSQF GRKADNHLPD
860 870 880 890 900
IAHAQSDGVD STSQTDSRSD HLGHLNPEDT LRAKTSRPQE LPVYSDDFED
910 920 930 940 950
LPNKSRQQMI FSNRPDSSRL GKTELSFSSS CDISRMDGLH SSEELRNLGW
960 970 980 990 1000
DFSQQERPTT TYQQPDSSYG TCGTHKYQQS TEHYGGTHNY WQGNGYWDPR
1010 1020 1030 1040 1050
SAGRPPGTGL AYDRIQGQVP DSLTDDREEE EHWDQRSGSH FSSPSNKFFF
1060 1070 1080 1090 1100
HQKDKGSVQA PEISSNSIKD ALVMNERKDF SKNFEKNDIK ERGPPKKRRQ
1110 1120 1130 1140 1150
ELESDSESDG ELQARKKVRV EMEQGESSVP QHSELMGPSC AMDDFRDPQR
1160 1170 1180 1190 1200
WKEFAKLGKM PCYFDLIEEN VYLTERKKNK SHRDIKRMQC ECTPLSKDER
1210 1220 1230 1240 1250
AQGEVACGED CLNRLLMIEC SSRCPNGDYC SNRRFQRKQH ADVEVILTEK
1260
KGWGLRAAKD LPS
Length:1,263
Mass (Da):143,551
Last modified:July 22, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF90C302170411B7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5F9SETD2_MOUSE
Histone-lysine N-methyltransferase ...
Setd2 Kiaa1732, Kmt3a
2,537Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEZ4A0A0G2JEZ4_MOUSE
Histone-lysine N-methyltransferase ...
Setd2
760Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEW8A0A0G2JEW8_MOUSE
Histone-lysine N-methyltransferase ...
Setd2
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDY1A0A0G2JDY1_MOUSE
Histone-lysine N-methyltransferase ...
Setd2
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDZ6A0A0G2JDZ6_MOUSE
Histone-lysine N-methyltransferase ...
Setd2
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000196814; ENSMUSP00000143774; ENSMUSG00000044791

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

jPOSTiA0A0G2JH06
ProteomicsDBi324753

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29842, 333 antibodies

Genome annotation databases

EnsembliENSMUST00000196814; ENSMUSP00000143774; ENSMUSG00000044791

Organism-specific databases

MGIiMGI:1918177, Setd2

Phylogenomic databases

GeneTreeiENSGT00940000160086

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Setd2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044791, Expressed in undifferentiated genital tubercle and 264 other tissues
ExpressionAtlasiA0A0G2JH06, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006560, AWS_dom
IPR042294, SETD2_animal
PANTHERiPTHR46711, PTHR46711, 1 hit
PfamiView protein in Pfam
PF17907, AWS, 1 hit
SMARTiView protein in SMART
SM00570, AWS, 1 hit
PROSITEiView protein in PROSITE
PS51215, AWS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0G2JH06_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0G2JH06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: June 2, 2021
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again