UniProtKB - A0A0G2JF23 (A0A0G2JF23_MOUSE)
Protein
Malate dehydrogenase
Gene
Mdh2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:1.1.1.37UniRule annotationARBA annotation
GO - Molecular functioni
- L-malate dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- malate metabolic process Source: InterPro
- tricarboxylic acid cycle Source: UniProtKB-KW
Keywordsi
Molecular function | OxidoreductaseUniRule annotation |
Biological process | Tricarboxylic acid cycleUniRule annotation |
Ligand | NADUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Mdh2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97050, Mdh2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000019179, Expressed in muscle of leg and 340 other tissues |
Interactioni
Subunit structurei
Homodimer.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 145 | Ldh_1_NInterPro annotationAdd BLAST | 130 | |
Domaini | 147 – 192 | Ldh_1_CInterPro annotationAdd BLAST | 46 |
Sequence similaritiesi
Belongs to the LDH/MDH superfamily.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00390000016686 |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
InterProi | View protein in InterPro IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR001252, Malate_DH_AS IPR010097, Malate_DH_type1 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01772, MDH_euk_gproteo, 1 hit |
PROSITEi | View protein in PROSITE PS00068, MDH, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A0G2JF23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSALARPAG AALRRSFSTS AQNSPLVSRL TLYDIAHTPG VAADLSHIET
60 70 80 90 100
RANVKGYLGP EQLPDCLKGC DVVVIPAGVP RKPGMTRDDL FNTNATIVAT
110 120 130 140 150
LTAACAQHCP EAMVCIIANP VNSTIPITAE VFKKHGVYNP NKIFGVTTLD
160 170 180 190
IVRANTFVAE LKGLDPARVN VPVIGGHAGK TIIPLISQVR DCKSSLLKD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP08249 | MDHM_MOUSE | Malate dehydrogenase, mitochondrial | Mdh2 Mor1 | 338 | Annotation score: | ||
A0A0G2JGY4 | A0A0G2JGY4_MOUSE | Malate dehydrogenase | Mdh2 | 153 | Annotation score: | ||
J3QMC8 | J3QMC8_MOUSE | Malate dehydrogenase, mitochondrial | Mdh2 | 51 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 199 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083948 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000200556; ENSMUSP00000142993; ENSMUSG00000019179 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083948 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0G2JF23 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A0A0G2JF23 |
Protocols and materials databases
Antibodypediai | 14905, 363 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000200556; ENSMUSP00000142993; ENSMUSG00000019179 |
Organism-specific databases
MGIi | MGI:97050, Mdh2 |
Phylogenomic databases
GeneTreei | ENSGT00390000016686 |
Miscellaneous databases
ChiTaRSi | Mdh2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019179, Expressed in muscle of leg and 340 other tissues |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
InterProi | View protein in InterPro IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR001252, Malate_DH_AS IPR010097, Malate_DH_type1 IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01772, MDH_euk_gproteo, 1 hit |
PROSITEi | View protein in PROSITE PS00068, MDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0G2JF23_MOUSE | |
Accessioni | A0A0G2JF23Primary (citable) accession number: A0A0G2JF23 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 22, 2015 |
Last sequence update: | July 22, 2015 | |
Last modified: | October 7, 2020 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |