UniProtKB - A0A0G2JE89 (A0A0G2JE89_MOUSE)
Protein
Phospholipid-transporting ATPase
Gene
Atp11b
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationARBA annotation EC:7.6.2.1
GO - Molecular functioni
- ATPase-coupled intramembrane lipid transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- phospholipid translocation Source: GO_Central
Keywordsi
Molecular function | TranslocaseUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Atp11bImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923545, Atp11b |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Endosome
- recycling endosome Source: MGI
Golgi apparatus
- trans-Golgi network Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 88 – 111 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 142 – 161 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 662 – 683 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 760 – 782 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 794 – 818 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 830 – 853 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 859 – 885 | HelicalUniRule annotationAdd BLAST | 27 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000037400, Expressed in retinal neural layer and 288 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 646 – 899 | PhoLip_ATPase_CInterPro annotationAdd BLAST | 254 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156162 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030362, ATP11B IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c |
PANTHERi | PTHR24092, PTHR24092, 1 hit PTHR24092:SF57, PTHR24092:SF57, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A0A0G2JE89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
LDSLIAVIEC QQPEADLYRF MGRMIITQQM EEIVRPLGPE SLLLRGARLK
60 70 80 90 100
NTKEIFGVAV YTGMETKMAL NYKSKSQKRS AVEKSMNTFL IIYLIILISE
110 120 130 140 150
AIISTILKYT WQAEEKWDEP WYNQKTEHQR NSSKILRFIS DFLAFLVLYN
160 170 180 190 200
FIIPISLYVT VEMQKFLGSF FIGWDLDLYH EESDQKAQVN TSDLNEELGQ
210 220 230 240 250
VEYVFTDKTG TLTENEMQFR ECSINGLKYQ EINGKLVPEG PSPDSTEGEV
260 270 280 290 300
PFLGSLSHLS NSAHLTATSL RTSPESETEL IKEHDLFFKA VSLCHTVQIS
310 320 330 340 350
NVQTDGIGDG PWQPNLAPAQ LEYYASSPDE KALVEAAARA GIIFVGISEE
360 370 380 390 400
TMEVKVLGRL ERYKLLHILE FDSDRRRMSV IVQAPSGEKL LFAKGAESSI
410 420 430 440 450
LPKCIGGEIA KTRIHVDEFA LKGLRTLCIA YRQFTAKEYE DVDRRLFEAR
460 470 480 490 500
TALQHREEKL ADAFQYIEKD LILLGATAVE DRLQDKVRET IEALRMAGIK
510 520 530 540 550
VWVLTGDKHE TAVSVSLSCG HFHRTMNILE LINQKSDSGC AEQLRQLARR
560 570 580 590 600
ITEDHVIQHG LVVDGTSLSL ALREHEKLFM EVCRNCSAVL CCRMAPLQKA
610 620 630 640 650
KVIRLIKISP EKPITLAVGD GANDVSMIQE AHVGIGIMGK EGRQAARNSD
660 670 680 690 700
YAIARFKFLS KLLFVHGHFY YIRIATLVQY FFYKNVCFIT PQFLYQFYCL
710 720 730 740 750
FSQQTLYDSV YLTLYNICFT SLPVLIYSLV EQHIDPHVLQ SKPTLYRDIS
760 770 780 790 800
KNGLLSIKAF LYWTVLGFSH AFIFFFGSYF LVGKDTSLLG NGQMFGNWTF
810 820 830 840 850
GTLVFTVMVI TVTVKMALET HFWTWINHLV TWGSIIFYFI FSLFYGGILW
860 870 880 890 900
PFLGSQNMYF VFIQLLSSGS AWFAILLMVV TCLFIDVVKK VFDRQLHPTS
910 920 930 940 950
TEKAQMYSNT VALSDEFIAL QPLSRARNQL GKLSLLKLIP VSSAWTPCAV
960
SQERPRVRLL EECWSES
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6DFW5 | Q6DFW5_MOUSE | Phospholipid-transporting ATPase | Atp11b | 1,175 | Annotation score: | ||
A0A0G2JED0 | A0A0G2JED0_MOUSE | ATPase, class VI, type 11B | Atp11b | 259 | Annotation score: | ||
A0A0G2JF19 | A0A0G2JF19_MOUSE | ATPase, class VI, type 11B | Atp11b | 124 | Annotation score: | ||
A0A1D5RLK3 | A0A1D5RLK3_MOUSE | ATPase, class VI, type 11B | Atp11b | 112 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC157780 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000198599; ENSMUSP00000142676; ENSMUSG00000037400 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC157780 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0G2JE89 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A0A0G2JE89 |
Protocols and materials databases
Antibodypediai | 33765, 130 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000198599; ENSMUSP00000142676; ENSMUSG00000037400 |
Organism-specific databases
MGIi | MGI:1923545, Atp11b |
Phylogenomic databases
GeneTreei | ENSGT00940000156162 |
Miscellaneous databases
ChiTaRSi | Atp11b, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037400, Expressed in retinal neural layer and 288 other tissues |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030362, ATP11B IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006539, P-type_ATPase_IV IPR001757, P_typ_ATPase IPR032630, P_typ_ATPase_c |
PANTHERi | PTHR24092, PTHR24092, 1 hit PTHR24092:SF57, PTHR24092:SF57, 1 hit |
Pfami | View protein in Pfam PF16212, PhoLip_ATPase_C, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01652, ATPase-Plipid, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0G2JE89_MOUSE | |
Accessioni | A0A0G2JE89Primary (citable) accession number: A0A0G2JE89 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 22, 2015 |
Last sequence update: | July 22, 2015 | |
Last modified: | October 7, 2020 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |