UniProtKB - A0A0G2JDM6 (A0A0G2JDM6_MOUSE)
Protein
Carboxylic ester hydrolase
Gene
Ache
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cholinesterase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Serine esteraseARBA annotation |
Protein family/group databases
ESTHERi | mouse-ACHE, AChE |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AcheImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:87876, Ache |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | UniRule annotationAdd BLAST | 31 | |
ChainiPRO_5005117840 | 32 – 526 | Carboxylic ester hydrolaseUniRule annotationAdd BLAST | 495 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000023328, Expressed in hypothalamus and 111 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 351 | COesteraseInterPro annotationAdd BLAST | 313 | |
Domaini | 356 – 475 | COesteraseInterPro annotationAdd BLAST | 120 | |
Domaini | 490 – 524 | AChE_tetraInterPro annotationAdd BLAST | 35 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000157637 |
Family and domain databases
Gene3Di | 3.40.50.1820, 2 hits |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014788, AChE_tetra IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS IPR000997, Cholinesterase |
Pfami | View protein in Pfam PF08674, AChE_tetra, 1 hit PF00135, COesterase, 2 hits |
PRINTSi | PR00878, CHOLNESTRASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A0G2JDM6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPPWYPLHT PSLAFPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG
60 70 80 90 100
IRLKAPGGPV SAFLGIPFAE PPVGSRRFMP PEPKRPWSGV LDATTFQNVC
110 120 130 140 150
YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPA SPTPVLIWIY
160 170 180 190 200
GGGFYSGAAS LDVYDGRFLA QVEGAVLVSM NYRVGTFGFL ALPGSREAPG
210 220 230 240 250
NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV GMHILSLPSR
260 270 280 290 300
SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL
310 320 330 340 350
IACLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPEALINTG
360 370 380 390 400
DFQDLQLAGR LAAQGARVYA YIFEHRASTL TWPLWMGVPH GYEIEFIFGL
410 420 430 440 450
PLDPSLNYTT EERIFAQRLM KYWTNFARTG DPNDPRDSKS PQWPPYTTAA
460 470 480 490 500
QQYVSLNLKP LEVRRGLRAQ TCAFWNRFLP KLLSATDTLD EAERQWKAEF
510 520
HRWSSYMVHW KNQFDHYSKQ ERCSDL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP21836 | ACES_MOUSE | Acetylcholinesterase | Ache | 614 | Annotation score: | ||
D3Z064 | D3Z064_MOUSE | Acetylcholinesterase | Ache | 40 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC243288 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000196208; ENSMUSP00000142427; ENSMUSG00000023328 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC243288 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0G2JDM6 |
ModBasei | Search... |
Protein family/group databases
ESTHERi | mouse-ACHE, AChE |
Protocols and materials databases
Antibodypediai | 16701, 751 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000196208; ENSMUSP00000142427; ENSMUSG00000023328 |
Organism-specific databases
MGIi | MGI:87876, Ache |
Phylogenomic databases
GeneTreei | ENSGT00940000157637 |
Miscellaneous databases
ChiTaRSi | Ache, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023328, Expressed in hypothalamus and 111 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1820, 2 hits |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR014788, AChE_tetra IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS IPR000997, Cholinesterase |
Pfami | View protein in Pfam PF08674, AChE_tetra, 1 hit PF00135, COesterase, 2 hits |
PRINTSi | PR00878, CHOLNESTRASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0G2JDM6_MOUSE | |
Accessioni | A0A0G2JDM6Primary (citable) accession number: A0A0G2JDM6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 22, 2015 |
Last sequence update: | July 22, 2015 | |
Last modified: | October 7, 2020 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |