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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Biotin carboxylase (accC1), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Biotin carboxylase (accC1), Biotin carboxylase (accC1), Biotin carboxylase (accC1), Biotin carboxylase (accC1), Biotin carboxylase (accC1), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseImported, TransferaseUniRule annotationSAAS annotationImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:2.1.3.15UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:BN1224_CV15_B_03520Imported, BN1224_GiD_A_04280Imported, BN1224_H12_DW_00460Imported, BN1224_MUL2216_E_01520Imported, BN1224_Panola_F_00840Imported, BN1224_PB1_B_04150Imported, BN1224_U1271_C_02560Imported, BN1224_UZG1_A_04270Imported, BN1224_Wien2_G_00510Imported, BN1224_YK41_BN_00520Imported, CWL029c_C_02550Imported
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)Imported
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 293CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 50Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0F7XIR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMELLPHEK QVVEYEKAIA EFKEKNKKNS LLSSSEIQKL EKRLDKLKEK
60 70 80 90 100
IYSDLTPWER VQICRHPSRP RTVNYIEGMC EEFVELCGDR TFRDDPAVVG
110 120 130 140 150
GFVKIQGQRF VLIGQEKGCD TASRLHRNFG MLCPEGFRKA LRLGKLAEKF
160 170 180 190 200
GLPVVFLVDT PGAYPGLTAE ERGQGWAIAK NLFELSRLAT PVIIVVIGEG
210 220 230 240 250
CSGGALGMAV GDSVAMLEHS YYSVISPEGC ASILWKDPKK NSEAASMLKM
260 270 280 290 300
HGENLKQFGI IDTVIKEPIG GAHHDPALVY SNVREFIIQE WLRLKDLAIE
310 320
ELLEKRYEKF RSIGLYETTS ESGPEA
Length:326
Mass (Da):36,591
Last modified:July 22, 2015 - v1
Checksum:iE6DC7779856CED3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN846998 Genomic DNA Translation: CRI38029.1
LN847003 Genomic DNA Translation: CRI40295.1
LN847008 Genomic DNA Translation: CRI41427.1
LN847177 Genomic DNA Translation: CRI43650.1
LN847226 Genomic DNA Translation: CRI45891.1
LN847232 Genomic DNA Translation: CRI47021.1
LN847244 Genomic DNA Translation: CRI49316.1
LN847240 Genomic DNA Translation: CRI50446.1
LN847245 Genomic DNA Translation: CRI51572.1
LN847254 Genomic DNA Translation: CRI52874.1
LN849039 Genomic DNA Translation: CRI73064.1

Genome annotation databases

PATRICifig|83558.13.peg.440

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN846998 Genomic DNA Translation: CRI38029.1
LN847003 Genomic DNA Translation: CRI40295.1
LN847008 Genomic DNA Translation: CRI41427.1
LN847177 Genomic DNA Translation: CRI43650.1
LN847226 Genomic DNA Translation: CRI45891.1
LN847232 Genomic DNA Translation: CRI47021.1
LN847244 Genomic DNA Translation: CRI49316.1
LN847240 Genomic DNA Translation: CRI50446.1
LN847245 Genomic DNA Translation: CRI51572.1
LN847254 Genomic DNA Translation: CRI52874.1
LN849039 Genomic DNA Translation: CRI73064.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICifig|83558.13.peg.440

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0F7XIR7_CHLPN
AccessioniPrimary (citable) accession number: A0A0F7XIR7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: November 7, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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