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Entry version 50 (19 Jan 2022)
Sequence version 1 (22 Jul 2015)
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Protein
Submitted name:

Leucine rich repeat (In FLII) interacting protein 1, isoform CRA_c

Gene

LRRFIP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine rich repeat (In FLII) interacting protein 1, isoform CRA_cImported
Submitted name:
Leucine-rich repeat flightless-interacting protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRFIP1Imported
ORF Names:hCG_2012960Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000124831

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124831, Expressed in renal medulla and 254 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 94DisorderedSequence analysisAdd BLAST53
Regioni337 – 359DisorderedSequence analysisAdd BLAST23
Regioni405 – 752DisorderedSequence analysisAdd BLAST348

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili101 – 128Sequence analysisAdd BLAST28
Coiled coili136 – 174Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 64Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi76 – 94Polar residuesSequence analysisAdd BLAST19
Compositional biasi420 – 460Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi470 – 487Polar residuesSequence analysisAdd BLAST18
Compositional biasi488 – 511Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi525 – 566Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi588 – 606Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi607 – 624Acidic residuesSequence analysisAdd BLAST18
Compositional biasi662 – 702Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi703 – 717Polar residuesSequence analysisAdd BLAST15
Compositional biasi727 – 752Basic and acidic residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRFIP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019139, LRRFIP1/2

The PANTHER Classification System

More...
PANTHERi
PTHR19212, PTHR19212, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09738, LRRFIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0F7NGI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI RMKELERQQK
60 70 80 90 100
EVEERPEKDF TEKGSRNMPG LSAATLASLG GTSSRRGSGD TSISIDTEAS
110 120 130 140 150
IREIKDSLAE VEEKYKKAMV SNAQLDNEKT NFMYQVDTLK DMLLELEEQL
160 170 180 190 200
AESRRQYEEK NKEFEREKHA HSILQFQFAE VKEALKQREE MLEKHGIILN
210 220 230 240 250
SEIATNGETS DTLNNVGYQG PTKMTKEELN ALKSTGDGTL GRASEVEVKN
260 270 280 290 300
EIVANVGKRE ILHNTEKEQH TEDTVKDCVD IEVFPAGENT EDQKSSEDTA
310 320 330 340 350
PFLGTLAGAT YEEQVQSQIL ESSSLPENTV QVESNEVMGA PDDRTRTPLE
360 370 380 390 400
PSNCWSDLDG GNHTENVGEA AVTQVEEQAG TVASCPLGHS DDTVYHDDKC
410 420 430 440 450
MVEVPQELET STGHSLEKEF TNQEAAEPKE VPAHSTEVGR DHNEEEGEET
460 470 480 490 500
GLRDEKPIKT EVPGSPAGTE GNCQEATGPS TVDTQNEPLD MKEPDEEKSD
510 520 530 540 550
QQGEALDSSQ KKTKNKKKKN KKKKSPVPVE TLKDVKKELT YQNTDLSEIK
560 570 580 590 600
EEEQVKSTDR KSAVEAQNEV TENPKQKIAA ESSENVDCPE NPKIKLDGKL
610 620 630 640 650
DQEGDDVQTA AEEVLADGDT LDFEDDTVQS SGPRAGGEEL DEGVAKDNAK
660 670 680 690 700
IDGATQSSPA EPKSEDADRC TLPEHESPSQ DISDACEAES TERCEMSEHP
710 720 730 740 750
SQTVRKALDS NSLENDDLSA PGREPGHFNP ESREDTRGGN EKGKSKEDCT

MS
Length:752
Mass (Da):82,689
Last modified:July 22, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF99016BC7CE54A60
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KP455483 mRNA Translation: AKH87514.1
CH471063 Genomic DNA Translation: EAW71124.1

NCBI Reference Sequences

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RefSeqi
NP_001131025.1, NM_001137553.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9208

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP455483 mRNA Translation: AKH87514.1
CH471063 Genomic DNA Translation: EAW71124.1
RefSeqiNP_001131025.1, NM_001137553.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1000, 337 antibodies from 30 providers

The DNASU plasmid repository

More...
DNASUi
9208

Genome annotation databases

GeneIDi9208

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9208
VEuPathDBiHostDB:ENSG00000124831

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9208, 9 hits in 1048 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRFIP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9208

Gene expression databases

BgeeiENSG00000124831, Expressed in renal medulla and 254 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR019139, LRRFIP1/2
PANTHERiPTHR19212, PTHR19212, 1 hit
PfamiView protein in Pfam
PF09738, LRRFIP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0F7NGI8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0F7NGI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2015
Last sequence update: July 22, 2015
Last modified: January 19, 2022
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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