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UniProtKB - A0A0F4FFH1 (A0A0F4FFH1_VIBCL)

Entry version 57 (19 Jan 2022)
Sequence version 1 (24 Jun 2015)
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Protein
Submitted name:

DNA-binding response regulator

Gene

arlR

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi124 – 218OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST95

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA-binding response regulatorImported
Submitted name:
Response regulator transcription factorImported
Submitted name:
Transcriptional regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arlRImported
ORF Names:D6U24_17345Imported, ERS013138_00366Imported, ERS013165_03143Imported, ERS013173_02027Imported, ERS013186_02400Imported, ERS013193_02940Imported, ERS013198_02446Imported, ERS013199_00949Imported, ERS013200_01715Imported, ERS013202_03194Imported, ERS013206_02224Imported, ERS013207_02282Imported, F0M16_11415Imported, FLM02_13915Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio choleraeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri666 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000043247 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000319979 Componenti: Unassembled WGS sequence
  • UP000471242 Componenti: Unassembled WGS sequence
  • UP000323225 Componenti: Unassembled WGS sequence
  • UP000042589 Componenti: Unassembled WGS sequence
  • UP000043560 Componenti: Unassembled WGS sequence
  • UP000044806 Componenti: Unassembled WGS sequence
  • UP000041770 Componenti: Unassembled WGS sequence
  • UP000040416 Componenti: Unassembled WGS sequence
  • UP000044503 Componenti: Unassembled WGS sequence
  • UP000045578 Componenti: Unassembled WGS sequence
  • UP000038065 Componenti: Unassembled WGS sequence
  • UP000043173 Componenti: Unassembled WGS sequence
  • UP000039886 Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei514-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 115Response regulatoryInterPro annotationAdd BLAST112
Domaini124 – 218OmpR/PhoB-typeInterPro annotationAdd BLAST95

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		817710at2

Family and domain databases

Conserved Domains Database

More...CDDi		cd00383, trans_reg_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011006, CheY-like_superfamily
IPR001867, OmpR/PhoB-type_DNA-bd
IPR016032, Sig_transdc_resp-reg_C-effctor
IPR001789, Sig_transdc_resp-reg_receiver
IPR039420, WalR-like
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR48111, PTHR48111, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00072, Response_reg, 1 hit
PF00486, Trans_reg_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00448, REC, 1 hit
SM00862, Trans_reg_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46894, SSF46894, 1 hit
SSF52172, SSF52172, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51755, OMPR_PHOB, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0F4FFH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQTLLLVED DKNLADGLLV SLEQAGYDCL HAETIADVKQ HWDKADLVIL 
        60         70         80         90        100
DRQLPDGDSV QHLMDWKKIK DIPVILLTAL VTVKDKVTGL DAGANDYLTK 
       110        120        130        140        150
PFAEAELFAR IRAQLRSPDS GQDDSKVVTS NLTIDKATRE VFFNGESITL 
       160        170        180        190        200
TRTEFDLLLF LASNLGRVFT RDELLDHVWG YNHFPTTRTV DTHVLQLRQK 
       210 
LPGLEIETLR GVGYKMKA
Length:218
Mass (Da):24,560
Last modified:June 24, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9FF7608A587127C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CWPD01000009 Genomic DNA Translation: CSA91348.1
CWOW01000019 Genomic DNA Translation: CSB03127.1
CWPO01000012 Genomic DNA Translation: CSB56408.1
CWQA01000013 Genomic DNA Translation: CSC17217.1
CWQX01000007 Genomic DNA Translation: CSC17925.1
CWRC01000003 Genomic DNA Translation: CSC22688.1
CWPZ01000012 Genomic DNA Translation: CSC24249.1
CWPV01000015 Genomic DNA Translation: CSC43104.1
CWQG01000018 Genomic DNA Translation: CSC51732.1
CWQD01000011 Genomic DNA Translation: CSC54307.1
CWQY01000009 Genomic DNA Translation: CSC57421.1
VUAA01000011 Genomic DNA Translation: KAA1254555.1
QZRB01000028 Genomic DNA Translation: MVD25114.1
VIOS01000055 Genomic DNA Translation: TQP11685.1

NCBI Reference Sequences

More...RefSeqi		WP_000815041.1, NZ_WSLE01000028.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AKO76784; AKO76784; EN12_16510
CPR27068; CPR27068; CPR27068
PYC80321; PYC80321; C9J66_13740

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57741966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vcq:EN18_01245

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CWPD01000009 Genomic DNA Translation: CSA91348.1
CWOW01000019 Genomic DNA Translation: CSB03127.1
CWPO01000012 Genomic DNA Translation: CSB56408.1
CWQA01000013 Genomic DNA Translation: CSC17217.1
CWQX01000007 Genomic DNA Translation: CSC17925.1
CWRC01000003 Genomic DNA Translation: CSC22688.1
CWPZ01000012 Genomic DNA Translation: CSC24249.1
CWPV01000015 Genomic DNA Translation: CSC43104.1
CWQG01000018 Genomic DNA Translation: CSC51732.1
CWQD01000011 Genomic DNA Translation: CSC54307.1
CWQY01000009 Genomic DNA Translation: CSC57421.1
VUAA01000011 Genomic DNA Translation: KAA1254555.1
QZRB01000028 Genomic DNA Translation: MVD25114.1
VIOS01000055 Genomic DNA Translation: TQP11685.1
RefSeqiWP_000815041.1, NZ_WSLE01000028.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAKO76784; AKO76784; EN12_16510
CPR27068; CPR27068; CPR27068
PYC80321; PYC80321; C9J66_13740
GeneIDi57741966
KEGGivcq:EN18_01245

Phylogenomic databases

OrthoDBi817710at2

Family and domain databases

CDDicd00383, trans_reg_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011006, CheY-like_superfamily
IPR001867, OmpR/PhoB-type_DNA-bd
IPR016032, Sig_transdc_resp-reg_C-effctor
IPR001789, Sig_transdc_resp-reg_receiver
IPR039420, WalR-like
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR48111, PTHR48111, 1 hit
PfamiView protein in Pfam
PF00072, Response_reg, 1 hit
PF00486, Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00448, REC, 1 hit
SM00862, Trans_reg_C, 1 hit
SUPFAMiSSF46894, SSF46894, 1 hit
SSF52172, SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51755, OMPR_PHOB, 1 hit
PS50110, RESPONSE_REGULATORY, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0F4FFH1_VIBCL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0F4FFH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: January 19, 2022
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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