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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Mycobacterium lepromatosis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 3 Mg2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi417Magnesium 1UniRule annotation1
Metal bindingi424Magnesium 1UniRule annotation1
Metal bindingi424Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotationImported
ORF Names:MLPM_0233Imported
OrganismiMycobacterium lepromatosisImported
Taxonomic identifieri480418 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000053699 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 504AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST319

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0F4ES47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNADPWDTDA ALPEQFRIRR DKRARLLAEG RDPYPVAIER THTLAEVRAA
60 70 80 90 100
YSDLTTDSAT DDIVGIAGRV IFARNSGKLC FATLQDGDGT NLQVMISLDK
110 120 130 140 150
VGAEALYAWK TDVDLGDIVY VHGNVISSRR GELSVLADSW QMTSKSLRPL
160 170 180 190 200
PVAHKEMSEE SRVRQRYVDL IVCPQTRTVA RQRIAVIRAI RTALERRGFL
210 220 230 240 250
EVETPMLQTL AGGAAARPFV THSNALDVDL YLRIAPELFL KRCIVGGFDK
260 270 280 290 300
VFELNRVFRN EGADSTHSPE FSMLEIYQTY GTYDDSAVVT RELIQEVADE
310 320 330 340 350
AIGTRQLLMP DDSVYDIDGE WATIQMYPSL SAVLGEEITP QTSVDRLRAI
360 370 380 390 400
ADRLGREIGP NILDKPSYGH GKLVEELWEH TVGNTLSAPT FVKDFPVETT
410 420 430 440 450
PLTRQHRSIP GVTEKWDLYL RGVELATGYS ELNDPVVQRE RFGQQVRAAA
460 470 480 490 500
VGEDEAMALD EEFLAALEYA MPPCTGTGMG IDRLLMSLTG LSIRETVLFP

IVRPHSN
Length:507
Mass (Da):56,470
Last modified:June 24, 2015 - v1
Checksum:i3D17D745DCACC993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JRPY01000014 Genomic DNA Translation: KJX75801.1
RefSeqiWP_045842350.1, NZ_JRPY01000014.1

Genome annotation databases

EnsemblBacteriaiKJX75801; KJX75801; MLPM_0233
PATRICifig|480418.6.peg.5771

Similar proteinsi

Entry informationi

Entry nameiA0A0F4ES47_9MYCO
AccessioniPrimary (citable) accession number: A0A0F4ES47
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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