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Protein

dCTP deaminase

Gene

dcd

Organism
Orientia tsutsugamushi str. UT76
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137Proton donor/acceptorUniRule annotation1
Binding sitei156dCTPUniRule annotation1
Binding sitei170dCTPUniRule annotation1
Binding sitei180dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 116dCTP bindingUniRule annotation6
Nucleotide bindingi135 – 137dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processNucleotide metabolismUniRule annotationSAAS annotation
LigandNucleotide-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotationSAAS annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotationImported
ORF Names:OTSUT76_0421Imported
OrganismiOrientia tsutsugamushi str. UT76Imported
Taxonomic identifieri682184 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
Proteomesi
  • UP000033364 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 164dUTPaseInterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0F3QWR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMSDNWIK KMAESENMIS PFVEKQVRAH NNQQILSYGL SSYGYDARVS
60 70 80 90 100
NEFKIFTNTK PSIIDPKKFD QDCLITKISD ICIIPPNSFA LGTTIEYFKM
110 120 130 140 150
PRDVIAICIG KSTYARCGII INVTPLEPEC EGHITLEFSN TTPLPAKIYA
160 170 180
GEGACQFLFL KGDQPCNISY LDRYGRYTKQ IGVTLPTV
Length:188
Mass (Da):21,125
Last modified:June 24, 2015 - v1
Checksum:iB8C44870650263C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LANZ01000008 Genomic DNA Translation: KJV96888.1

Genome annotation databases

EnsemblBacteriaiKJV96888; KJV96888; OTSUT76_0421
PATRICifig|682184.3.peg.4425

Similar proteinsi

Entry informationi

Entry nameiA0A0F3QWR8_ORITS
AccessioniPrimary (citable) accession number: A0A0F3QWR8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: June 20, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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