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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Gammaproteobacteria bacterium BRH_c0
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi67MagnesiumUniRule annotation1
Metal bindingi139MagnesiumUniRule annotation1
Metal bindingi142MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repairUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotationSAAS annotation (EC:3.1.22.4UniRule annotationSAAS annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
ORF Names:VR73_04785Imported
OrganismiGammaproteobacteria bacterium BRH_c0Imported
Taxonomic identifieri1629722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteria
Proteomesi
  • UP000033581 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0F2P329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVILGIDPG SIKTGFGVIE ARGSKVFYVA SGIIKLPAVA LPEKLKIICA
60 70 80 90 100
SVAEIIASHC PTEMAVEEVF FARDPRAALK LGQARGAAIV AGVQADLPVS
110 120 130 140 150
EYSAKTVKQS VVGTGAATKD QVSQMVVRLL SLESAPREDA ADALAVALCH
160 170 180
AHSMRSAISM ATGLAGSGQA IAKTRYARGR LKEIHYK
Length:187
Mass (Da):19,498
Last modified:June 24, 2015 - v1
Checksum:iBA50E8397E2D8BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LADM01000041 Genomic DNA Translation: KJS08673.1

Genome annotation databases

PATRICifig|1629722.3.peg.601

Similar proteinsi

Entry informationi

Entry nameiA0A0F2P329_9GAMM
AccessioniPrimary (citable) accession number: A0A0F2P329
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: July 18, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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