Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homoserine dehydrogenase

Gene

P875_00010715

Organism
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 3 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (P875_00095235), Homoserine dehydrogenase (P875_00010715)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (P875_00095235), Homoserine dehydrogenase (P875_00010715)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95NADPUniRule annotation1
Binding sitei119NADPUniRule annotation1
Binding sitei212SubstrateUniRule annotation1
Active sitei227Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00050;UER00063

UPA00051;UER00465

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenaseUniRule annotation (EC:1.1.1.3UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
ORF Names:P875_00010715Imported
OrganismiAspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)Imported
Taxonomic identifieri1403190 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000033540 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A0F0IGP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 146NAD_binding_3InterPro annotationAdd BLAST136
Domaini154 – 362Homoserine_dhInterPro annotationAdd BLAST209

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR001342 HDH_cat
IPR019811 HDH_CS
IPR022697 HDH_short
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00742 Homoserine_dh, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF036497 HDH_short, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01042 HOMOSER_DHGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0F0IGP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNPVYLGVI GVGGVGTAFL SQLARLPNAP KLVLLARSSQ TLQSPTPAYS
60 70 80 90 100
PAIPAADWKT AVETPSLIKS GALSVDEIAS YLSSAPGRSI LVDNTSDLTL
110 120 130 140 150
ASSYPVFLRK GISIVTPNKK GFSSDLSLWK DIFAAAAEGK ALVYHESTVG
160 170 180 190 200
AGLPVISTLR DLVSTGDEVT RIEGVFSGTL SFLFNTFAPV SGPSGAKWSE
210 220 230 240 250
VVAKAKELGY TEPDPRDDLN GMDVARKLTI LARIAGLEVQ SPDSFPIESL
260 270 280 290 300
IPKELESVPS TADGIKEFMT RLPEFDGQMS AIKEAAEKEG KVVRYVGSVD
310 320 330 340 350
VGKKEVRVGL QYFDKDSSIA GLKGSDNIIS FYTKRYGGNP LVVQGSGAGG
360
DVTAMGVSAD LIKVVQRLQ
Length:369
Mass (Da):38,934
Last modified:June 24, 2015 - v1
Checksum:i53DDA041D2806FD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JZEE01000376 Genomic DNA Translation: KJK65018.1

Genome annotation databases

EnsemblFungiiKJK65018; KJK65018; P875_00010715

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JZEE01000376 Genomic DNA Translation: KJK65018.1

3D structure databases

ProteinModelPortaliA0A0F0IGP7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiKJK65018; KJK65018; P875_00010715

Enzyme and pathway databases

UniPathwayi
UPA00050;UER00063

UPA00051;UER00465

Family and domain databases

InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR001342 HDH_cat
IPR019811 HDH_CS
IPR022697 HDH_short
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00742 Homoserine_dh, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF036497 HDH_short, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01042 HOMOSER_DHGENASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0F0IGP7_ASPPU
AccessioniPrimary (citable) accession number: A0A0F0IGP7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: March 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again