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Protein

NAD kinase

Gene

ppnK

Organism
Burkholderiaceae bacterium 26
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1
Binding sitei193NADUniRule annotation1
Binding sitei195NADUniRule annotation1
Binding sitei230NAD; via carbonyl oxygenUniRule annotation1
Binding sitei264NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 92NADUniRule annotation2
Nucleotide bindingi165 – 166NADUniRule annotation2
Nucleotide bindingi206 – 211NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotationSAAS annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:ppnKImported
Synonyms:nadKUniRule annotation
ORF Names:UB44_03845Imported
OrganismiBurkholderiaceae bacterium 26Imported
Taxonomic identifieri1619951 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceae
Proteomesi
  • UP000033646 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0F0E5X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPPSAVAP QAPAASSSPV SPFKTVALVG RYSAANIAGP LMELASCIAA
60 70 80 90 100
RGHDIVFERD TALNIGVQDY PALPPEEMAR HADVAVVLGG DGTLLGIGRH
110 120 130 140 150
LAGASVPVIG VNHGRLGFMT DIPFDDVHTV LPDMLSGRYE AETRTLLQAQ
160 170 180 190 200
VVRDDEVIFS ALAFNDVVVN RSGTSGMVEL AVSVDGFFMY NQRSDGLIVS
210 220 230 240 250
TPTGSTAYAL SAGGPILHPA LSGLVLVPIA PHSLSNRPIV IPQDAEVVIQ
260 270 280 290 300
VTSGRDASVN FDMQSLTSLL PGDRIVVRRS ERTVRLLHPI GYNYYATLRK
310
KLHWHEYPTE DNRL
Length:314
Mass (Da):33,550
Last modified:June 24, 2015 - v1
Checksum:iB9EF7594A717658F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JYOB01000003 Genomic DNA Translation: KJK04119.1
RefSeqiWP_045202648.1, NZ_JYOB01000003.1

Genome annotation databases

EnsemblBacteriaiKJK04119; KJK04119; UB44_03845
PATRICifig|1619951.3.peg.3773

Similar proteinsi

Entry informationi

Entry nameiA0A0F0E5X2_9BURK
AccessioniPrimary (citable) accession number: A0A0F0E5X2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: June 20, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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