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Entry version 27 (12 Aug 2020)
Sequence version 1 (24 Jun 2015)
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Protein
Submitted name:

Transmembrane transport protein MmpL7

Gene

mmpL7

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane transport protein MmpL7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mmpL7Imported
ORF Names:ERS013471_00225Imported, ERS023446_00025Imported, ERS024276_00190Imported, ERS027661_00388Imported, ERS075361_02387Imported, ERS094182_02269Imported, F6W99_01558Imported, SAMEA2683035_02323Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000047893 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 76HelicalSequence analysisAdd BLAST20
Transmembranei225 – 244HelicalSequence analysisAdd BLAST20
Transmembranei251 – 272HelicalSequence analysisAdd BLAST22
Transmembranei284 – 306HelicalSequence analysisAdd BLAST23
Transmembranei326 – 343HelicalSequence analysisAdd BLAST18
Transmembranei355 – 379HelicalSequence analysisAdd BLAST25
Transmembranei400 – 424HelicalSequence analysisAdd BLAST25
Transmembranei774 – 795HelicalSequence analysisAdd BLAST22
Transmembranei802 – 823HelicalSequence analysisAdd BLAST22
Transmembranei835 – 857HelicalSequence analysisAdd BLAST23
Transmembranei878 – 897HelicalSequence analysisAdd BLAST20
Transmembranei903 – 926HelicalSequence analysisAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 392MMPLInterPro annotationAdd BLAST305
Domaini622 – 921MMPLInterPro annotationAdd BLAST300

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004869, MMPL_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03176, MMPL, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0E8VUX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSNIDRINS PAWMPSPAGR LHRIRYIRLK KSSPDCRATI TSGSADGQRR
60 70 80 90 100
SPRLTNLLVV AAWVAAAVIA NLLLTFTQAE PHDTSPALLP QDAKTAAATS
110 120 130 140 150
RIAQAFPGTG SNAIAYLVVE GGSTLEPQDQ PYYDAAVGAL RADTRHVGSV
160 170 180 190 200
LDWWSDPVTA PLGTSPDGRS ATAMVWLRGE AGTTQAAESL DAVRSVLRQL
210 220 230 240 250
PPSEGLRASI VVPAITNDMP MQITAWQSAT IVTVAAVIAV LLLLRARLSV
260 270 280 290 300
RAAAIVLLTA DLSLAVAWPL AAVVRGHDWG TDSVFSWTLA AVLTIGTITA
310 320 330 340 350
ATMLAARLGS DAGHSAAPTY RDSLPAFALP GACVAIFTGP LLLARTPALH
360 370 380 390 400
GVGTAGLGVF VALAASLTVL PALIALAGAS RQLPAPTTGA GWTGRLSLPV
410 420 430 440 450
SSASALGTAA VLAICMLPII GMRWGVAENP TRQGGAQVLP GNALPDVVVI
460 470 480 490 500
KSARDLRDPA ALIAINQVSH RLVEVPGVRK VESAAWPAGV PWTDASLSSA
510 520 530 540 550
AGRLADQLGQ QAGSFVPAVT AIKSMKSIIE QMSGAVDQLD STVNVTLAGA
560 570 580 590 600
RQAQQYLDPM LAAARNLKNK TTELSEYLET IHTWIVGFTN CPDDVLCTAM
610 620 630 640 650
RKVIEPYDIV VTGMNELSTG ADRISAISTQ TMSALSSAPR MVAQMRSALA
660 670 680 690 700
QVRSFVPKLE TTIQDAMPQI AQASAMLKNL SADFADTGEG GFHLSRKDLA
710 720 730 740 750
DPSYRHVRES MFSSDGTATR LFLYSDGQLD LAAAARAQQL EIAAGKAMKY
760 770 780 790 800
GSLVDSQVTV GGAAQIAAAV RDALIHDAVL LAVILLTVVA LASMWRGAVH
810 820 830 840 850
GAAVGVGVLA SYLAALGVSI ALWQHLLDRE LNALVPLVSF AVLASCGVPY
860 870 880 890 900
LVAGIKAGRI ADEATGARSK GAVSGRGAVA PLAALGGVFG AGLVLVSGGS
910 920 930
FSVLSQIGTV VVLGLGVLIT VQRAWLPTTP GRR
Length:933
Mass (Da):96,595
Last modified:June 24, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i311C4922902CE0CB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CNCN01000022 Genomic DNA Translation: CKN69319.1
CNFU01000043 Genomic DNA Translation: CKQ97938.1
CQAC01000017 Genomic DNA Translation: CNG83511.1
CQGE01000001 Genomic DNA Translation: CNM32582.1
CQTT01000003 Genomic DNA Translation: CNY05201.1
CVKR01000016 Genomic DNA Translation: CRF26823.1
CP044345 Genomic DNA Translation: QEX90770.1
FPTZ01000015 Genomic DNA Translation: SGH91957.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC47402; AMC47402; RN05_3126
CKN69319; CKN69319; ERS024276_00190
CKQ97938; CKQ97938; ERS027661_00388
CKU33480; CKU33480; ERS031537_00317
CNG67902; CNG67902; ERS124361_01558
CNM32582; CNM32582; ERS023446_00025
CNY05201; CNY05201; ERS013471_00225
CRH11319; CRH11319; BN1303_01049
CRH12421; CRH12421; BN1213_01793

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.1097

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CNCN01000022 Genomic DNA Translation: CKN69319.1
CNFU01000043 Genomic DNA Translation: CKQ97938.1
CQAC01000017 Genomic DNA Translation: CNG83511.1
CQGE01000001 Genomic DNA Translation: CNM32582.1
CQTT01000003 Genomic DNA Translation: CNY05201.1
CVKR01000016 Genomic DNA Translation: CRF26823.1
CP044345 Genomic DNA Translation: QEX90770.1
FPTZ01000015 Genomic DNA Translation: SGH91957.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC47402; AMC47402; RN05_3126
CKN69319; CKN69319; ERS024276_00190
CKQ97938; CKQ97938; ERS027661_00388
CKU33480; CKU33480; ERS031537_00317
CNG67902; CNG67902; ERS124361_01558
CNM32582; CNM32582; ERS023446_00025
CNY05201; CNY05201; ERS013471_00225
CRH11319; CRH11319; BN1303_01049
CRH12421; CRH12421; BN1213_01793
PATRICifig|1773.211.peg.1097

Family and domain databases

InterProiView protein in InterPro
IPR004869, MMPL_dom
PfamiView protein in Pfam
PF03176, MMPL, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0E8VUX1_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0E8VUX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: August 12, 2020
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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