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Protein

Lysine--tRNA ligase

Gene

lysS_2

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 3 Mg2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi415Magnesium 1UniRule annotation1
Metal bindingi422Magnesium 1UniRule annotation1
Metal bindingi422Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysS_2Imported
Synonyms:lysSUniRule annotation, lysS_1Imported
ORF Names:ERS007657_01228Imported, ERS007665_01671Imported, ERS007670_02894Imported, ERS007672_02986Imported, ERS007703_03055Imported, ERS023446_03820Imported, ERS024213_00381Imported, ERS024276_02257Imported, ERS027644_01504Imported, ERS027651_03870Imported, ERS027652_00531Imported, ERS027654_00970Imported, ERS027656_01091Imported, ERS027661_02841Imported, ERS027666_02607Imported, ERS031537_01275Imported, ERS124361_02031Imported, SAMEA2682864_02664Imported, SAMEA2683035_00697Imported
OrganismiMycobacterium tuberculosisImported
Taxonomic identifieri1773 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000049498 Componenti: Unassembled WGS sequence
  • UP000049299 Componenti: Unassembled WGS sequence
  • UP000049861 Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000046932 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000183655 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000049258 Componenti: Unassembled WGS sequence
  • UP000050143 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000049139 Componenti: Unassembled WGS sequence
  • UP000050038 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 502AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST324

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E8V7T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAADTAEDL PEQFRIRRDK RARLLAQGRD PYPVAVPRTH TLAEVRAAHP
60 70 80 90 100
DLPIDTATED IVGVAGRVIF ARNSGKLCFA TLQDGDGTQL QVMISLDKVG
110 120 130 140 150
QAALDAWKAD VDLGDIVYVH GAVISSRRGE LSVLADCWRI AAKSLRPLPV
160 170 180 190 200
AHKEMSEESR VRQRYVDLIV RPEARAVARL RIAVVRAIRT ALQRRGFLEV
210 220 230 240 250
ETPVLQTLAG GAAARPFATH SNALDIDLYL RIAPELFLKR CIVGGFDKVF
260 270 280 290 300
ELNRVFRNEG ADSTHSPEFS MLETYQTYGT YDDSAVVTRE LIQEVADEAI
310 320 330 340 350
GTRQLPLPDG SVYDIDGEWA TIQMYPSLSV ALGEEITPQT TVDRLRGIAD
360 370 380 390 400
SLGLEKDPAI HDNRGFGHGK LIEELWERTV GKSLSAPTFV KDFPVQTTPL
410 420 430 440 450
TRQHRSIPGV TEKWDLYLRG IELATGYSEL SDPVVQRERF ADQARAAAAG
460 470 480 490 500
DDEAMVLDED FLAALEYGMP PCTGTGMGID RLLMSLTGLS IRETVLFPIV

RPHSN
Length:505
Mass (Da):55,709
Last modified:June 24, 2015 - v1
Checksum:iE12FFC867152740C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CGCX01000354 Genomic DNA Translation: CFR73860.1
CNDE01000052 Genomic DNA Translation: CKO39198.1
CNCN01000576 Genomic DNA Translation: CKO97835.1
CNFQ01000068 Genomic DNA Translation: CKR01934.1
CNFR01000139 Genomic DNA Translation: CKR26174.1
CNFV01000129 Genomic DNA Translation: CKR34422.1
CNFW01000218 Genomic DNA Translation: CKR54042.1
CNFU01000654 Genomic DNA Translation: CKS27269.1
CIEA01000067 Genomic DNA Translation: CKS93437.1
CNGG01000530 Genomic DNA Translation: CKT34853.1
CNIS01000158 Genomic DNA Translation: CKU79802.1
CHDS01000033 Genomic DNA Translation: CNG83462.1
CQGE01000148 Genomic DNA Translation: CNN53772.1
CQPW01000290 Genomic DNA Translation: CNU81207.1
CQPL01000691 Genomic DNA Translation: CNV29983.1
CHEE01000618 Genomic DNA Translation: COW08502.1
CSAE01000382 Genomic DNA Translation: COW20578.1
FPTZ01000003 Genomic DNA Translation: SGH25785.1
FPXX01000016 Genomic DNA Translation: SGM54587.1
RefSeqiWP_003419514.1, NZ_PYQC01000030.1

Genome annotation databases

EnsemblBacteriaiAMC48112; AMC48112; RN05_3836
CFR73860; CFR73860; ERS007657_01228
CKO39198; CKO39198; ERS024213_00381
CKO97835; CKO97835; ERS024276_02257
CKR01934; CKR01934; ERS027652_00531
CKR26174; CKR26174; ERS027654_00970
CKR34422; CKR34422; ERS027656_01091
CKR54042; CKR54042; ERS027644_01504
CKS27269; CKS27269; ERS027661_02841
CKT34853; CKT34853; ERS027666_02607
CKU79802; CKU79802; ERS031537_01275
CNG83462; CNG83462; ERS124361_02031
CNN53772; CNN53772; ERS023446_03820
CNU81207; CNU81207; ERS007665_01671
CNV29983; CNV29983; ERS007670_02894
CNZ16100; CNZ16100; ERS013471_03690
COW08502; COW08502; ERS007672_02986
COW20578; COW20578; ERS007703_03055
PATRICifig|1773.206.peg.3944

Similar proteinsi

Entry informationi

Entry nameiA0A0E8V7T2_MYCTX
AccessioniPrimary (citable) accession number: A0A0E8V7T2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: July 18, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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