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Entry version 40 (11 Dec 2019)
Sequence version 1 (24 Jun 2015)
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Protein

tRNA-dihydrouridine synthase

Gene

dus

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.UniRule annotation

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei120Proton donorUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processtRNA processingUniRule annotation
LigandFlavoprotein, FMNUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA-dihydrouridine synthaseUniRule annotation (EC:1.3.1.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dusImported
Synonyms:dusBImported
ORF Names:ERS007703_02847Imported, ERS023446_03168Imported, ERS027651_03310Imported, EZX46_00865Imported, FDK60_06490Imported, FDK62_20500Imported, SAMEA2682864_03982Imported, SAMEA2683035_03400Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000183655 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000306581 Componenti: Unassembled WGS sequence
  • UP000298273 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000305204 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dus family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02801 DUS_like_FMN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1200.80, 1 hit
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR024036 tRNA-dHydroUridine_Synthase_C
IPR004652 tRNA_dU_NifR3
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01207 Dus, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006621 Dus, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00737 nifR3_yhdG, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01136 UPF0034, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0E8UBT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRRAIQPS PALRIGPIEL ASPVVLAPMA GVTNVAFRAL CRQLEQSKVG
60 70 80 90 100
TVSGLYVCEM VTARALIERH PVTMHMTTFS ADESPRSLQL YTVDPDTTYA
110 120 130 140 150
AARMIAGEGL ADHIDMNFGC PVPKVTKRGG GAALPFKRRL FGQIVAAAVR
160 170 180 190 200
ATEGTDIPVT VKFRIGIDDA HHTHLDAGRI AEAEGAAAVA LHARTAAQRY
210 220 230 240 250
SGTADWEQIA RLKQHVRTIP VLGNGDIYDA GDALAMMSTT GCDGVVIGRG
260 270 280 290 300
CLGRPWLFAE LSAAFTGSPA PTPPTLGEVA DIIRRHGTLL AAHFGEDKGM
310 320 330 340 350
RDIRKHIAWY LHGFPAGSAL RRALAMVKTF DELDCLLDRL DGTVPFPDSA
360 370 380
TGARGRQGSP ARVALPDGWL TDPDDCRVPE GADAMGSGG
Length:389
Mass (Da):41,388
Last modified:June 24, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11F5EB06E561E0DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CIEA01000045 Genomic DNA Translation: CKS67719.1
CQGE01000088 Genomic DNA Translation: CNN37254.1
CSAE01000339 Genomic DNA Translation: COW13215.1
FPTZ01000030 Genomic DNA Translation: SGI34522.1
FPXX01000039 Genomic DNA Translation: SGN30123.1
SMOE01000069 Genomic DNA Translation: TFB30535.1
SZTS01000015 Genomic DNA Translation: TKR40693.1
SZTU01000125 Genomic DNA Translation: TKR49602.1

NCBI Reference Sequences

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RefSeqi
WP_003898601.1, NZ_VOOP01000075.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC45154; AMC45154; RN05_0878
CFE40380; CFE40380; ERS007681_02489
CKP16229; CKP16229; ERS024213_01590
CKQ79780; CKQ79780; ERS027652_00112
CKQ96358; CKQ96358; ERS027659_00456
CKR21670; CKR21670; ERS027661_00807
CKR33359; CKR33359; ERS027644_00999
CKR83981; CKR83981; ERS027656_02169
CNH65078; CNH65078; ERS124361_04118
CNN37254; CNN37254; ERS023446_03168
CNU05335; CNU05335; ERS007663_00397
COW13215; COW13215; ERS007703_02847
COW21973; COW21973; ERS007720_02048
COW29523; COW29523; ERS007672_03463
COW39121; COW39121; ERS007679_03778
COW53676; COW53676; ERS007722_02940
CRH13276; CRH13276; BN1303_02012
CRH15664; CRH15664; BN1213_03429

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.1376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CIEA01000045 Genomic DNA Translation: CKS67719.1
CQGE01000088 Genomic DNA Translation: CNN37254.1
CSAE01000339 Genomic DNA Translation: COW13215.1
FPTZ01000030 Genomic DNA Translation: SGI34522.1
FPXX01000039 Genomic DNA Translation: SGN30123.1
SMOE01000069 Genomic DNA Translation: TFB30535.1
SZTS01000015 Genomic DNA Translation: TKR40693.1
SZTU01000125 Genomic DNA Translation: TKR49602.1
RefSeqiWP_003898601.1, NZ_VOOP01000075.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC45154; AMC45154; RN05_0878
CFE40380; CFE40380; ERS007681_02489
CKP16229; CKP16229; ERS024213_01590
CKQ79780; CKQ79780; ERS027652_00112
CKQ96358; CKQ96358; ERS027659_00456
CKR21670; CKR21670; ERS027661_00807
CKR33359; CKR33359; ERS027644_00999
CKR83981; CKR83981; ERS027656_02169
CNH65078; CNH65078; ERS124361_04118
CNN37254; CNN37254; ERS023446_03168
CNU05335; CNU05335; ERS007663_00397
COW13215; COW13215; ERS007703_02847
COW21973; COW21973; ERS007720_02048
COW29523; COW29523; ERS007672_03463
COW39121; COW39121; ERS007679_03778
COW53676; COW53676; ERS007722_02940
CRH13276; CRH13276; BN1303_02012
CRH15664; CRH15664; BN1213_03429
PATRICifig|1773.206.peg.1376

Family and domain databases

CDDicd02801 DUS_like_FMN, 1 hit
Gene3Di1.10.1200.80, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR024036 tRNA-dHydroUridine_Synthase_C
IPR004652 tRNA_dU_NifR3
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS
PfamiView protein in Pfam
PF01207 Dus, 1 hit
PIRSFiPIRSF006621 Dus, 1 hit
TIGRFAMsiTIGR00737 nifR3_yhdG, 1 hit
PROSITEiView protein in PROSITE
PS01136 UPF0034, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0E8UBT1_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0E8UBT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: December 11, 2019
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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