Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 44 (12 Aug 2020)
Sequence version 1 (24 Jun 2015)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Carbon starvation protein A

Gene

cstA

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Carbon starvation protein AImported
Submitted name:
Carbon starvation protein A cstAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cstAImported
ORF Names:ERS007688_02242Imported, FRD82_06390Imported, SAMEA2683035_03254Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 62HelicalSequence analysisAdd BLAST20
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei128 – 147HelicalSequence analysisAdd BLAST20
Transmembranei153 – 175HelicalSequence analysisAdd BLAST23
Transmembranei196 – 218HelicalSequence analysisAdd BLAST23
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei256 – 275HelicalSequence analysisAdd BLAST20
Transmembranei281 – 311HelicalSequence analysisAdd BLAST31
Transmembranei323 – 340HelicalSequence analysisAdd BLAST18
Transmembranei360 – 386HelicalSequence analysisAdd BLAST27
Transmembranei398 – 421HelicalSequence analysisAdd BLAST24
Transmembranei503 – 521HelicalSequence analysisAdd BLAST19
Transmembranei554 – 575HelicalSequence analysisAdd BLAST22
Transmembranei587 – 608HelicalSequence analysisAdd BLAST22
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 442CstAInterPro annotationAdd BLAST376
Domaini503 – 633CstA_5TMInterPro annotationAdd BLAST131

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025299, CstA_C
IPR003706, CstA_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02554, CstA, 1 hit
PF13722, CstA_5TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0E8U089-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPTPSNRI EERSGHASCV RADADLPPVA ILGRSPITLR HKIFFVAVAV
60 70 80 90 100
IGALAWTVVA FFRNEPVNAV WIVVAAGCTY IIGFRFYARL IEMKVVRPRD
110 120 130 140 150
DHATPAEILD DGTDYVPTDR RVVFGHHFAA IAGAGPLVGP VLATQMGYLP
160 170 180 190 200
SSIWIVVGAV LAGCVQDYLV LWISVRRRGR SLGQMVRDEL GATAGVAALV
210 220 230 240 250
GIPVIITIVI AVLALVVVRA LAKSPWGVFS IAMTIPIAIF MGCYLRFLRP
260 270 280 290 300
GRVSEVSLIG IGLLLLAVVS GDWVAHTSWG AAWFSLSPVT LCWLLISYGF
310 320 330 340 350
AASVLPVWLL LAPRDYLSTF MKVGTIALLA IGVCAAHPII EAPAVSKFAG
360 370 380 390 400
SGNGPVFAGS LFPFLFITIA CGALSGFDAL ICSGTTPKML EKEGQMRVIG
410 420 430 440 450
YGGMMTESFV AVIALLTAAI LDQHLYFTLN APSLHTHDSA ATAAKYVNGL
460 470 480 490 500
GLTGSPVTPD HISQAAASVG EQTIVSRTGG APTLAFGMAE MLHRVVGGVG
510 520 530 540 550
LKAFWYHFAI MFEALFILTT VDAGTRAARF MISDALGNFG GVLRKLQNPS
560 570 580 590 600
WRPGAWACSL VVVAAWGSIL LLGVTDPLGG INTLFPLFGI ANQLLAGIAL
610 620 630 640 650
TVITVVVIKK GRLKWAWIPG IPLLWDLAVT LTASWQKIFS ADPSVGYWTQ
660 670 680 690 700
HAHYAAAQHA GETAFGSATN ADEINDVVRN TFVQGTLSIV FVVVVVLVVV
710 720 730 740 750
AGVIVALKTI RGRGIPLAED DPAPSTLFAP AGLIPTAAER KLQRRLGAPA

SASVAAPD
Length:758
Mass (Da):80,072
Last modified:June 24, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i487FB72C9897B815
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOH01000357 Genomic DNA Translation: CFE53402.1
FPTZ01000027 Genomic DNA Translation: SGI28112.1
VOOQ01000141 Genomic DNA Translation: TXB94204.1

NCBI Reference Sequences

More...
RefSeqi
WP_003899901.1, NZ_VOOP01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CFE53402; CFE53402; ERS007688_02242
CKR49083; CKR49083; ERS027653_01436
CKR92981; CKR92981; ERS027656_02304
CRH12197; CRH12197; BN1213_01667

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOH01000357 Genomic DNA Translation: CFE53402.1
FPTZ01000027 Genomic DNA Translation: SGI28112.1
VOOQ01000141 Genomic DNA Translation: TXB94204.1
RefSeqiWP_003899901.1, NZ_VOOP01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCFE53402; CFE53402; ERS007688_02242
CKR49083; CKR49083; ERS027653_01436
CKR92981; CKR92981; ERS027656_02304
CRH12197; CRH12197; BN1213_01667

Family and domain databases

InterProiView protein in InterPro
IPR025299, CstA_C
IPR003706, CstA_N
PfamiView protein in Pfam
PF02554, CstA, 1 hit
PF13722, CstA_5TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0E8U089_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0E8U089
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: August 12, 2020
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again