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Entry version 40 (17 Jun 2020)
Sequence version 1 (24 Jun 2015)
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Protein
Submitted name:

Sensor histidine kinase

Gene

prrB

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation EC:2.7.13.3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseSAAS annotationImported, Transferase
Biological processTwo-component regulatory systemSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sensor histidine kinaseImported (EC:2.7.13.3Imported)
Submitted name:
Two component sensor histidine kinase PrrBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prrBImported
ORF Names:ERS007663_03177Imported, ERS007670_02682Imported, ERS007679_03219Imported, ERS007681_02281Imported, ERS007688_03009Imported, ERS007703_03803Imported, ERS007722_03107Imported, ERS007741_02234Imported, ERS013471_02403Imported, ERS023446_02139Imported, ERS024276_02517Imported, ERS027646_01446Imported, ERS027659_01421Imported, ERS027661_02525Imported, ERS075361_00983Imported, ERS094182_02793Imported, F6W99_03595Imported, SAMEA2683035_02229Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000048948 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 64HelicalSequence analysisAdd BLAST24
Transmembranei173 – 196HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini193 – 245HAMPInterPro annotationAdd BLAST53
Domaini260 – 469Histidine kinaseInterPro annotationAdd BLAST210

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06225 HAMP, 1 hit
cd00082 HisKA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00672 HAMP, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00344 BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00304 HAMP, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0E8B9H5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGCCIPSA ESDSCCVCSD GACMNILSRI FARTPSLRTR VVVATAIGAA
60 70 80 90 100
IPVLIVGTVV WVGITNDRKE RLDRRLDEAA GFAIPFVPRG LDEIPRSPND
110 120 130 140 150
QDALITVRRG NVIKSNSDIT LPKLQDDYAD TYVRGVRYRV RTVEIPGPEP
160 170 180 190 200
TSVAVGATYD ATVAETNNLH RRVLLICTFA IGAAAVFAWL LAAFAVRPFK
210 220 230 240 250
QLAEQTRSID AGDEAPRVEV HGASEAIEIA EAMRGMLQRI WNEQNRTKEA
260 270 280 290 300
LASARDFAAV SSHELRTPLT AMRTNLEVLS TLDLPDDQRK EVLNDVIRTQ
310 320 330 340 350
SRIEATLSAL ERLAQGELST SDDHVPVDIT DLLDRAAHDA ARIYPDLDVS
360 370 380 390 400
LVPSPTCIIV GLPAGLRLAV DNAIANAVKH GGATLVQLSA VSSRAGVEIA
410 420 430 440 450
IDDNGSGVPE GERQVVFERF SRGSTASHSG SGLGLALVAQ QAQLHGGTAS
460
LENSPLGGAR LVLRLPGPS
Length:469
Mass (Da):50,037
Last modified:June 24, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EAE233F38ED0A59
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000287 Genomic DNA Translation: CFE39892.1
CFOH01000586 Genomic DNA Translation: CFE62011.1
CNCN01000681 Genomic DNA Translation: CKP17781.1
CNFT01000257 Genomic DNA Translation: CKR44323.1
CNFU01000542 Genomic DNA Translation: CKS05522.1
CNGE01000210 Genomic DNA Translation: CKS20542.1
CQAC01000005 Genomic DNA Translation: CNG31224.1
CQGE01000043 Genomic DNA Translation: CNN09562.1
CQPL01000608 Genomic DNA Translation: CNV19735.1
CQPV01000595 Genomic DNA Translation: CNV40410.1
CQTT01000067 Genomic DNA Translation: CNY69952.1
CSAD01000549 Genomic DNA Translation: COW14014.1
CHKL01000242 Genomic DNA Translation: COW33830.1
CSAE01000562 Genomic DNA Translation: COW52545.1
CSAM01000285 Genomic DNA Translation: COW62858.1
CVKR01000022 Genomic DNA Translation: CRF27334.1
CP044345 Genomic DNA Translation: QEX92778.1
FPTZ01000014 Genomic DNA Translation: SGH88200.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC45237; AMC45237; RN05_0961
CFE39892; CFE39892; ERS007681_02281
CFE62011; CFE62011; ERS007688_03009
CKO98586; CKO98586; ERS024213_01307
CKP17781; CKP17781; ERS024276_02517
CKR44323; CKR44323; ERS027659_01421
CKR69708; CKR69708; ERS027653_01946
CKR79233; CKR79233; ERS027656_02088
CKS05522; CKS05522; ERS027661_02525
CKS20542; CKS20542; ERS027646_01446
CKU58792; CKU58792; ERS031537_00846
CNH24937; CNH24937; ERS124361_03219
CNN09562; CNN09562; ERS023446_02139
CNV19735; CNV19735; ERS007670_02682
CNV40410; CNV40410; ERS007663_03177
CNY69952; CNY69952; ERS013471_02403
COW14014; COW14014; ERS007679_03219
COW33830; COW33830; ERS007741_02234
COW52545; COW52545; ERS007703_03803
COW62858; COW62858; ERS007722_03107
CRH13423; CRH13423; BN1303_02092

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.1647

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000287 Genomic DNA Translation: CFE39892.1
CFOH01000586 Genomic DNA Translation: CFE62011.1
CNCN01000681 Genomic DNA Translation: CKP17781.1
CNFT01000257 Genomic DNA Translation: CKR44323.1
CNFU01000542 Genomic DNA Translation: CKS05522.1
CNGE01000210 Genomic DNA Translation: CKS20542.1
CQAC01000005 Genomic DNA Translation: CNG31224.1
CQGE01000043 Genomic DNA Translation: CNN09562.1
CQPL01000608 Genomic DNA Translation: CNV19735.1
CQPV01000595 Genomic DNA Translation: CNV40410.1
CQTT01000067 Genomic DNA Translation: CNY69952.1
CSAD01000549 Genomic DNA Translation: COW14014.1
CHKL01000242 Genomic DNA Translation: COW33830.1
CSAE01000562 Genomic DNA Translation: COW52545.1
CSAM01000285 Genomic DNA Translation: COW62858.1
CVKR01000022 Genomic DNA Translation: CRF27334.1
CP044345 Genomic DNA Translation: QEX92778.1
FPTZ01000014 Genomic DNA Translation: SGH88200.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC45237; AMC45237; RN05_0961
CFE39892; CFE39892; ERS007681_02281
CFE62011; CFE62011; ERS007688_03009
CKO98586; CKO98586; ERS024213_01307
CKP17781; CKP17781; ERS024276_02517
CKR44323; CKR44323; ERS027659_01421
CKR69708; CKR69708; ERS027653_01946
CKR79233; CKR79233; ERS027656_02088
CKS05522; CKS05522; ERS027661_02525
CKS20542; CKS20542; ERS027646_01446
CKU58792; CKU58792; ERS031537_00846
CNH24937; CNH24937; ERS124361_03219
CNN09562; CNN09562; ERS023446_02139
CNV19735; CNV19735; ERS007670_02682
CNV40410; CNV40410; ERS007663_03177
CNY69952; CNY69952; ERS013471_02403
COW14014; COW14014; ERS007679_03219
COW33830; COW33830; ERS007741_02234
COW52545; COW52545; ERS007703_03803
COW62858; COW62858; ERS007722_03107
CRH13423; CRH13423; BN1303_02092
PATRICifig|1773.211.peg.1647

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0E8B9H5_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0E8B9H5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: June 17, 2020
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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