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Entry version 44 (13 Nov 2019)
Sequence version 1 (24 Jun 2015)
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Protein
Submitted name:

Phospholipase C

Gene

plcA_1

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phospholipase CImported
Submitted name:
Phospholipase C 3 plcCImported (EC:3.1.4.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:plcA_1Imported
Synonyms:plcAImported, plcA_2Imported, plcA_3Imported
ORF Names:ERS007657_00735Imported, ERS007665_00933Imported, ERS007672_01573Imported, ERS007679_00657Imported, ERS007681_01383Imported, ERS007703_02905Imported, ERS007722_02392Imported, ERS023446_03895Imported, ERS024276_02132Imported, ERS027644_02118Imported, ERS027651_02449Imported, ERS027652_00554Imported, ERS027654_01422Imported, ERS027656_02974Imported, ERS027659_01312Imported, ERS027661_01773Imported, ERS031537_02448Imported, ERS124361_04494Imported, SAMEA2682835_07842Imported, SAMEA2682864_02994Imported, SAMEA2683035_04108Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000049498 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000298647 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000183655 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000049258 Componenti: Unassembled WGS sequence
  • UP000050143 Componenti: Unassembled WGS sequence
  • UP000050038 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501503708120 – 517Sequence analysisAdd BLAST498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.720.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR007312 Phosphoesterase
IPR006311 TAT_signal

The PANTHER Classification System

More...
PANTHERi
PTHR31956 PTHR31956, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04185 Phosphoesterase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51318 TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0E7ZUN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSQGAFAGM SRRAFLAKAA GAGAAAVLTD WAAPVIEKAY GAGPCSGHLT
60 70 80 90 100
DIEHIVLCLQ ENRSFDHYFG TLSAVDGFDT PTPLFQQKGW NPETQALDPT
110 120 130 140 150
GITLPYRINT TGGPNGVGEC VNDPDHQWIA AHLSWNGGAN DGWLPAQART
160 170 180 190 200
RSVANTPVVM GYYARPDIPI HYLLADTFTI CDQYFSSLLG GTMPNRLYWI
210 220 230 240 250
SATVNPDGDQ GGPQIVEPAI QPKLTFTWRI MPQNLSDAGI SWKVYNSKLL
260 270 280 290 300
GGLNDTSLSR NGYVGSFKQA ADPRSDLARY GIAPAYPWDF IRDVINNTLP
310 320 330 340 350
QVSWVVPLTV ESEHPSFPVA VGAVTIVNLI RVLLRNPAVW EKTALIIAYD
360 370 380 390 400
EHGGFFDHVT PLTAPEGTPG EWIPNSVDID KVDGSGGIRG PIGLGFRVPC
410 420 430 440 450
FVISPYSRGG LMVHDRFDHT SQLQLIGKRF GVPVPNLTPW RASVTGDMTS
460 470 480 490 500
AFNFAAPPDP SPPNLDHPVR QLPKVAKCVP NVVLGFLNEG LPYRVPYPQT
510
TPVQESGPAR PIPSGIC
Length:517
Mass (Da):55,896
Last modified:June 24, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B9D4241E09755AE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000137 Genomic DNA Translation: CFE39012.1
CGCX01000177 Genomic DNA Translation: CFR69022.1
CNCN01000521 Genomic DNA Translation: CKO86930.1
CNFQ01000072 Genomic DNA Translation: CKR03189.1
CNFT01000232 Genomic DNA Translation: CKR39821.1
CNFR01000233 Genomic DNA Translation: CKR46153.1
CNFU01000324 Genomic DNA Translation: CKR62137.1
CNFW01000353 Genomic DNA Translation: CKR80538.1
CIEA01000024 Genomic DNA Translation: CKS25375.1
CNFV01000541 Genomic DNA Translation: CKS41974.1
CNIS01000401 Genomic DNA Translation: CKV29564.1
CHDS01000183 Genomic DNA Translation: CNH84433.1
CQGE01000159 Genomic DNA Translation: CNN55662.1
CQPW01000125 Genomic DNA Translation: CNU35626.1
CSAD01000055 Genomic DNA Translation: COU92917.1
CHEE01000241 Genomic DNA Translation: COV32310.1
CSAE01000353 Genomic DNA Translation: COW15505.1
CSAM01000174 Genomic DNA Translation: COW31280.1
FPPU01000093 Genomic DNA Translation: SGE39841.1
FPTZ01000054 Genomic DNA Translation: SGI67360.1
FPXX01000020 Genomic DNA Translation: SGM71145.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC46785; AMC46785; RN05_2509
CFE39012; CFE39012; ERS007681_01383
CFR69022; CFR69022; ERS007657_00735
CKO86930; CKO86930; ERS024276_02132
CKR03189; CKR03189; ERS027652_00554
CKR39821; CKR39821; ERS027659_01312
CKR46153; CKR46153; ERS027654_01422
CKR62137; CKR62137; ERS027661_01773
CKR80538; CKR80538; ERS027644_02118
CKS41974; CKS41974; ERS027656_02974
CKV29564; CKV29564; ERS031537_02448
CNH84433; CNH84433; ERS124361_04494
CNN55662; CNN55662; ERS023446_03895
CNU35626; CNU35626; ERS007665_00933
CNZ21575; CNZ21575; ERS013471_03828
COU92917; COU92917; ERS007679_00657
COV32310; COV32310; ERS007672_01573
COW15505; COW15505; ERS007703_02905
COW31280; COW31280; ERS007722_02392
CRH09570; CRH09570; BN1303_00223
CRH11214; CRH11214; BN1213_01179

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.87

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000137 Genomic DNA Translation: CFE39012.1
CGCX01000177 Genomic DNA Translation: CFR69022.1
CNCN01000521 Genomic DNA Translation: CKO86930.1
CNFQ01000072 Genomic DNA Translation: CKR03189.1
CNFT01000232 Genomic DNA Translation: CKR39821.1
CNFR01000233 Genomic DNA Translation: CKR46153.1
CNFU01000324 Genomic DNA Translation: CKR62137.1
CNFW01000353 Genomic DNA Translation: CKR80538.1
CIEA01000024 Genomic DNA Translation: CKS25375.1
CNFV01000541 Genomic DNA Translation: CKS41974.1
CNIS01000401 Genomic DNA Translation: CKV29564.1
CHDS01000183 Genomic DNA Translation: CNH84433.1
CQGE01000159 Genomic DNA Translation: CNN55662.1
CQPW01000125 Genomic DNA Translation: CNU35626.1
CSAD01000055 Genomic DNA Translation: COU92917.1
CHEE01000241 Genomic DNA Translation: COV32310.1
CSAE01000353 Genomic DNA Translation: COW15505.1
CSAM01000174 Genomic DNA Translation: COW31280.1
FPPU01000093 Genomic DNA Translation: SGE39841.1
FPTZ01000054 Genomic DNA Translation: SGI67360.1
FPXX01000020 Genomic DNA Translation: SGM71145.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC46785; AMC46785; RN05_2509
CFE39012; CFE39012; ERS007681_01383
CFR69022; CFR69022; ERS007657_00735
CKO86930; CKO86930; ERS024276_02132
CKR03189; CKR03189; ERS027652_00554
CKR39821; CKR39821; ERS027659_01312
CKR46153; CKR46153; ERS027654_01422
CKR62137; CKR62137; ERS027661_01773
CKR80538; CKR80538; ERS027644_02118
CKS41974; CKS41974; ERS027656_02974
CKV29564; CKV29564; ERS031537_02448
CNH84433; CNH84433; ERS124361_04494
CNN55662; CNN55662; ERS023446_03895
CNU35626; CNU35626; ERS007665_00933
CNZ21575; CNZ21575; ERS013471_03828
COU92917; COU92917; ERS007679_00657
COV32310; COV32310; ERS007672_01573
COW15505; COW15505; ERS007703_02905
COW31280; COW31280; ERS007722_02392
CRH09570; CRH09570; BN1303_00223
CRH11214; CRH11214; BN1213_01179
PATRICifig|1773.206.peg.87

Family and domain databases

Gene3Di3.40.720.10, 2 hits
InterProiView protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR007312 Phosphoesterase
IPR006311 TAT_signal
PANTHERiPTHR31956 PTHR31956, 1 hit
PfamiView protein in Pfam
PF04185 Phosphoesterase, 1 hit
PROSITEiView protein in PROSITE
PS51318 TAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0E7ZUN4_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0E7ZUN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: November 13, 2019
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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