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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Verrucomicrobia bacterium IMCC26134
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi265Magnesium or manganese 1UniRule annotation1
Metal bindingi278Magnesium or manganese 1UniRule annotation1
Metal bindingi278Magnesium or manganese 2UniRule annotation1
Metal bindingi280Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
ORF Names:IMCC26134_02620Imported
OrganismiVerrucomicrobia bacterium IMCC26134Imported
Taxonomic identifieri1637999 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaunclassified Verrucomicrobia
Proteomesi
  • UP000033046 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 311ATP-graspInterPro annotationAdd BLAST196

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01921

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 2 hits
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E3UHH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVILSATSA LSRATGLSPR ITVLAGGVSS EREVSLGSGA AAAQALARLW
60 70 80 90 100
PTRLIDVTAP DLPLGLDPDR DVVFSTLHGT FGEDGGMQAL LDAACIVYAG
110 120 130 140 150
CGTASSALTM DKAATKRAAA QVGVNVAADL TFSAATRPEV GEVIAALGER
160 170 180 190 200
VVFKPNDQGS SVGLALPEGR EEIGSALAVI SAGNWIAEPR LVGRELSVGV
210 220 230 240 250
LGGKAMGVVE IRPRSGVYDF ASKYTKGATE YLAPAPLEAE VAMAVQRAAE
260 270 280 290 300
SAFAACGCRD YARVDFILIS ENEFYLLEIN TLPGMKETSL LPMSARCAGL
310 320
DFTALVRELV VPAVNRLQAA RFLANK
Length:326
Mass (Da):33,829
Last modified:June 24, 2015 - v1
Checksum:iC4392913A6DA1D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011265 Genomic DNA Translation: AKC81946.1
RefSeqiWP_046297336.1, NZ_CP011265.1

Genome annotation databases

EnsemblBacteriaiAKC81946; AKC81946; IMCC26134_02620
KEGGivba:IMCC26134_02620
PATRICifig|1637999.3.peg.559

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011265 Genomic DNA Translation: AKC81946.1
RefSeqiWP_046297336.1, NZ_CP011265.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAKC81946; AKC81946; IMCC26134_02620
KEGGivba:IMCC26134_02620
PATRICifig|1637999.3.peg.559

Phylogenomic databases

KOiK01921

Enzyme and pathway databases

UniPathwayi
UPA00219

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 2 hits
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0E3UHH8_9BACT
AccessioniPrimary (citable) accession number: A0A0E3UHH8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: October 10, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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