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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Methanosarcina mazei WWM610
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processNucleotide metabolismUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
ORF Names:MSMAW_2964Imported
OrganismiMethanosarcina mazei WWM610Imported
Taxonomic identifieri1434117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000033058 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA0A0E3Q145
SMRiA0A0E3Q145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 158dUTPaseInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z0E8X

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00635 dUTPase_arch, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR023537 dUTPase_archaeal
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E3Q145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLSSNELR KLIKANPPLL ENAVDTETQI QPNGLELTLK EIKTIEGAGA
60 70 80 90 100
VDFDNSERKV PDAKPLEFGK DGWIHLPEGI YKVIFNEIVN IPMNLAAIAK
110 120 130 140 150
PRSSLIRCGA TLETAVWDAG YRGRSESMLV VYNPAGFKLK KNARIMQLLF
160 170
YTLNTEVEEG YSGVYQNENT N
Length:171
Mass (Da):19,028
Last modified:June 24, 2015 - v1
Checksum:iA6E96FE90FF20A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009509 Genomic DNA Translation: AKB41955.1
RefSeqiWP_011033571.1, NZ_CP009509.1

Genome annotation databases

EnsemblBacteriaiAKB41955; AKB41955; MSMAW_2964
GeneIDi24881309
PATRICifig|1434117.4.peg.3757

Similar proteinsi

Entry informationi

Entry nameiA0A0E3Q145_METMZ
AccessioniPrimary (citable) accession number: A0A0E3Q145
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: January 31, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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