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Protein

Putative K(+)-stimulated pyrophosphate-energized sodium pump

Gene

hppA

Organism
Methanosarcina mazei WWM610
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Requires K+ for maximal activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei463Determinant of potassium dependenceUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processIon transport, Sodium transportUniRule annotation, Transport
LigandMagnesiumUniRule annotation, PotassiumUniRule annotation, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Short name:
Na(+)-PPaseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
ORF Names:MSMAW_0617Imported
OrganismiMethanosarcina mazei WWM610Imported
Taxonomic identifieri1434117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000033058 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 23HelicalUniRule annotationAdd BLAST18
Transmembranei57 – 77HelicalUniRule annotationAdd BLAST21
Transmembranei124 – 152HelicalUniRule annotationAdd BLAST29
Transmembranei158 – 179HelicalUniRule annotationAdd BLAST22
Transmembranei237 – 259HelicalUniRule annotationAdd BLAST23
Transmembranei265 – 286HelicalUniRule annotationAdd BLAST22
Transmembranei298 – 318HelicalUniRule annotationAdd BLAST21
Transmembranei330 – 348HelicalUniRule annotationAdd BLAST19
Transmembranei390 – 417HelicalUniRule annotationAdd BLAST28
Transmembranei469 – 489HelicalUniRule annotationAdd BLAST21
Transmembranei501 – 523HelicalUniRule annotationAdd BLAST23
Transmembranei573 – 606HelicalUniRule annotationAdd BLAST34
Transmembranei656 – 675HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z01O9

Family and domain databases

HAMAPiMF_01129 PPase_energized_pump, 1 hit
InterProiView protein in InterPro
IPR004131 PPase-energised_H-pump
PANTHERiPTHR31998 PTHR31998, 1 hit
PfamiView protein in Pfam
PF03030 H_PPase, 1 hit
PIRSFiPIRSF001265 H+-PPase, 1 hit
TIGRFAMsiTIGR01104 V_PPase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E3PTK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMLIYLTPI CALIGLIFAG ISYKNVRNEG EGNELIKKIT AAIHGGAMVY
60 70 80 90 100
LNRQYRAIAV FVVFIAIVLA LVLPNGVLTA ACFVFGAVLS ATAGYAGMLT
110 120 130 140 150
ATIANGRTTN AATRGIGPAF KVSFASGTVM GMSVVGLGLF GLSLSFIILG
160 170 180 190 200
NIYTDMDLFT LLNIIAGFSF GASSIALFAR VGGGIFTKAA DVGADLVGKV
210 220 230 240 250
EAGIPEDDPR NPAVIADNVG DNVGDIAGMG ADLYESYVGS IIATMLLAAS
260 270 280 290 300
TAAATFPGIP VMNVVMVPLV IAAVGILASV IGTFFVRTNK TESSAIHMAF
310 320 330 340 350
NMGLIAAIVL TVIASYVVTG HLLGGYGLNV FFSTVAGLVA GFLIGQITEH
360 370 380 390 400
YTSYDKKPTL TVAHSCQTGS ATNVITGFAK GMESTLWPAV IISIAIYIAF
410 420 430 440 450
QLAGLYGIAI AAVGMLATLG ISLSVDAYGP VADNAGGIAE MSHQKKEVRQ
460 470 480 490 500
ITDTLDAVGN TTAAMGKGFA IGSAALTALS LFASYAIAVG LTSIDVMNPN
510 520 530 540 550
VFIGLIIGAM LPFLFSSMTI LAVGNAAGEV VVEVRRQFKE IKGLMEGKAD
560 570 580 590 600
PDYSKCITIS THSALKEMIP PGILAVIAPI LVGLVLGAGA LGGLLAGSVV
610 620 630 640 650
SGFMLAITMS NAGGSWDNAK KFIELGNFGG KGSDAHKAGV TGDTVGDPFK
660 670
DTAGPAINIL IKLMSIVALV FAPLFI
Length:676
Mass (Da):69,221
Last modified:June 24, 2015 - v1
Checksum:i36DFDBDA732A9AD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009509 Genomic DNA Translation: AKB39608.1
RefSeqiWP_011032651.1, NZ_CP009509.1

Genome annotation databases

EnsemblBacteriaiAKB39608; AKB39608; MSMAW_0617
GeneIDi24880497
PATRICifig|1434117.4.peg.756

Similar proteinsi

Entry informationi

Entry nameiA0A0E3PTK8_METMZ
AccessioniPrimary (citable) accession number: A0A0E3PTK8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: May 23, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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