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Protein

Putative K(+)-stimulated pyrophosphate-energized sodium pump

Gene

hppA

Organism
Methanosarcina siciliae C2J
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Requires K+ for maximal activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei472Determinant of potassium dependenceUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processIon transport, Sodium transportUniRule annotation, Transport
LigandMagnesiumUniRule annotation, PotassiumUniRule annotation, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pumpUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphataseUniRule annotation
Pyrophosphate-energized inorganic pyrophosphataseUniRule annotation
Short name:
Na(+)-PPaseUniRule annotation
Gene namesi
Name:hppAUniRule annotation
ORF Names:MSSAC_3615Imported
OrganismiMethanosarcina siciliae C2JImported
Taxonomic identifieri1434118 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000033123 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Transmembranei67 – 86HelicalUniRule annotationAdd BLAST20
Transmembranei92 – 113HelicalUniRule annotationAdd BLAST22
Transmembranei133 – 158HelicalUniRule annotationAdd BLAST26
Transmembranei170 – 188HelicalUniRule annotationAdd BLAST19
Transmembranei246 – 268HelicalUniRule annotationAdd BLAST23
Transmembranei274 – 295HelicalUniRule annotationAdd BLAST22
Transmembranei307 – 327HelicalUniRule annotationAdd BLAST21
Transmembranei339 – 357HelicalUniRule annotationAdd BLAST19
Transmembranei398 – 426HelicalUniRule annotationAdd BLAST29
Transmembranei478 – 503HelicalUniRule annotationAdd BLAST26
Transmembranei510 – 532HelicalUniRule annotationAdd BLAST23
Transmembranei577 – 596HelicalUniRule annotationAdd BLAST20
Transmembranei603 – 625HelicalUniRule annotationAdd BLAST23
Transmembranei665 – 684HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KOiK15987
OrthoDBiPOG093Z01O9

Family and domain databases

HAMAPiMF_01129 PPase_energized_pump, 1 hit
InterProiView protein in InterPro
IPR004131 PPase-energised_H-pump
PANTHERiPTHR31998 PTHR31998, 1 hit
PfamiView protein in Pfam
PF03030 H_PPase, 1 hit
PIRSFiPIRSF001265 H+-PPase, 1 hit
TIGRFAMsiTIGR01104 V_PPase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E3PS68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGRMVEIM DMLIYLAPIC ALIGLIFAGI SYKNVQNEGA GNDLIKKITA
60 70 80 90 100
SIHGGAMVYL NRQYRAIAVF VVFLAIVIAL ILPNGILTAA CFVFGAVLSA
110 120 130 140 150
TAGYAGMLTA TLANGRTTNA ATRGIGPAFR VSFASGTVMG MSVVGLGLFG
160 170 180 190 200
LSLSFIFLDS VYSNLDLLTI VNIVAGFSLG ASSIALFARV GGGIFTKAAD
210 220 230 240 250
VGADLVGKVE AGIPEDDPRN PAVIADNVGD NVGDIAGMGA DLYESYVGSI
260 270 280 290 300
LATMLLAAST AATTFPNIPV ENVILVPLTI SAIGILASIV GTFFVRTNKT
310 320 330 340 350
EASALHMAFN MGLIAAIILT VIASYFVTSL LLGEYGLNVF FATVAGLVAG
360 370 380 390 400
FLIGQITEHY TSYDRKPTLS VANSCQTGSA TNIITGFAKG MESTLWPVVL
410 420 430 440 450
ISIAIYIAFQ LAGLYGIAIA AVGMLATLGI SLSVDAYGPV ADNAGGIAEM
460 470 480 490 500
SHQKEEVRQI TDTLDAVGNT TAAIGKGFAI GSAALTALAL FASYGIAVGL
510 520 530 540 550
SAIDVMNPNV FIGLIIGAML PYLFSSMTIL AVGNAAGEVV VEVRRQFKEI
560 570 580 590 600
PGLMEGKADP DYGKCIAIST HSALKEMIPP GLLAVIAPLL VGLVLGPGAL
610 620 630 640 650
GGLLAGSVAS GFMIAITMSN AGGAWDNAKK YIELGNFGGK GSDAHKAGVT
660 670 680
GDTVGDPFKD TAGPAINILI KLMSIVAVVF APLFM
Length:685
Mass (Da):70,206
Last modified:June 24, 2015 - v1
Checksum:i77C334CD62AD978E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009508 Genomic DNA Translation: AKB38205.1

Genome annotation databases

EnsemblBacteriaiAKB38205; AKB38205; MSSAC_3615
KEGGimsj:MSSAC_3615
PATRICifig|1434118.4.peg.4667

Similar proteinsi

Entry informationi

Entry nameiA0A0E3PS68_9EURY
AccessioniPrimary (citable) accession number: A0A0E3PS68
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: May 23, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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