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Entry version 27 (17 Jun 2020)
Sequence version 1 (24 Jun 2015)
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Protein

2-oxoacid:ferredoxin oxidoreductase subunit alpha

Gene

SSOP1_2913

Organism
Saccharolobus solfataricus (Sulfolobus solfataricus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kcat is 452 min(-1) for 2-oxoglutarate as substrate. Kcat is 144 min(-1) for pyruvate as substrate. Kcat is 93 min(-1) for 2-oxobutyrate as substrate.
  1. KM=163 µM for 2-oxoglutarate1 Publication
  2. KM=275 µM for pyruvate1 Publication
  3. KM=516 µM for 2-oxobutyrate1 Publication

    pH dependencei

    Optimum pH is between 7-8.1 Publication

    Temperature dependencei

    Optimum temperature is 70 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei257SubstrateBy similarity1
    Binding sitei345SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandPyruvate

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    2-oxoacid:ferredoxin oxidoreductase subunit alpha1 Publication (EC:1.2.7.111 Publication)
    Short name:
    OFORCurated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    ORF Names:SSOP1_2913Imported, SULA_0623Imported, SULB_0625Imported, SULC_0623Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharolobus solfataricus (Sulfolobus solfataricus)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2287 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSaccharolobus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000033057 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000076770 Componenti: Chromosome i
    • UP000033085 Componenti: Chromosome
    • UP000033106 Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004455271 – 6322-oxoacid:ferredoxin oxidoreductase subunit alphaAdd BLAST632

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer composed of an alpha and a beta subunit.

    1 Publication

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A0A0E3JT70

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi254 – 258YPITP motifBy similarity5

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The Tyr-Pro-Ile-Thr-Pro (YPITP) motif is important for the turnover of the reaction, presumably through its flexibility and mobility.By similarity

    Phylogenomic databases

    KEGG Orthology (KO)

    More...
    KOi
    K00174

    Database of Orthologous Groups

    More...
    OrthoDBi
    41678at2157

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.920, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR022367, 2-oxoacid/accept_OxRdtase_asu
    IPR033412, PFOR_II
    IPR019752, Pyrv/ketoisovalerate_OxRed_cat
    IPR002880, Pyrv_Fd/Flavodoxin_OxRdtase_N
    IPR002869, Pyrv_flavodox_OxRed_cen
    IPR029061, THDP-binding
    IPR009014, Transketo_C/PFOR_II

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF17147, PFOR_II, 1 hit
    PF01558, POR, 1 hit
    PF01855, POR_N, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52518, SSF52518, 1 hit
    SSF52922, SSF52922, 1 hit
    SSF53323, SSF53323, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR03710, OAFO_sf, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A0E3JT70-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRISWMIGGA QGSGVDTSAN IFGNAVAASG YYIYGNREYY SNIKGRHSYF
    60 70 80 90 100
    NLTISDKPPR SIAQQIEILT SFDAETIFQH FNEVKDVLIY STEVENTKAE
    110 120 130 140 150
    QVQSMEPEIT EHVVKFLKEK GYGTTVKDVI NYLKKEKGVK VIPIDYMEIL
    160 170 180 190 200
    KKVADQAKVQ LSVADRARNT IAIAASYKLL GLKEQYLINS ITRTFRQEVF
    210 220 230 240 250
    AKINTIAAQL AMQQIQPMYN LPELPNNEEK INLDGNTAAA IGKIYGGLRF
    260 270 280 290 300
    QSYYPITPAS DESVFIEAHQ TVFTVDPKTG EKRKSTIVVV QAEDELAAIN
    310 320 330 340 350
    MASGAALTGV RAATATSGPG FSLMVEGMGW AGMNEVPVVI TYYIRGGPST
    360 370 380 390 400
    GQPTRTSQAD LMFALNAGHG EFPRIVIASG DHVEAFHDGT WALNLAQKYQ
    410 420 430 440 450
    TPVIHLVDKA LANSYSIIPK KTLGMENIRI EKGKIVINTN TPELKRFEIT
    460 470 480 490 500
    EDGISPFAPL GTARVHYTGD EHDEYGFIAE ASENREKMYE KRIKKLMTAD
    510 520 530 540 550
    KEIPEESRVN VYGNTDSKVA IITWGSPKGA ILDAMEELEN EGIKPMLIQI
    560 570 580 590 600
    RMFSPFPKNL MRKLLNGKEF IIDVESNYFG QAGEVLKLNT GIEPTHYILK
    610 620 630
    WNGRPMMRDE VKEGIKAVVQ KGERRVVLHG GA
    Length:632
    Mass (Da):70,228
    Last modified:June 24, 2015 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6648EF7531835277
    GO

    <p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 69300 Da. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CP011055 Genomic DNA Translation: AKA73017.1
    CP011056 Genomic DNA Translation: AKA75715.1
    CP011057 Genomic DNA Translation: AKA78407.1
    LT549890 Genomic DNA Translation: SAI86467.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_009989033.1, NZ_LT549890.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AKA73017; AKA73017; SULB_0625
    AKA75715; AKA75715; SULC_0623
    AKA78407; AKA78407; SULA_0623

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    44128564

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ssoa:SULA_0623
    ssof:SULC_0623
    ssol:SULB_0625

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|2287.6.peg.649

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP011055 Genomic DNA Translation: AKA73017.1
    CP011056 Genomic DNA Translation: AKA75715.1
    CP011057 Genomic DNA Translation: AKA78407.1
    LT549890 Genomic DNA Translation: SAI86467.1
    RefSeqiWP_009989033.1, NZ_LT549890.1

    3D structure databases

    SMRiA0A0E3JT70
    ModBaseiSearch...

    Genome annotation databases

    EnsemblBacteriaiAKA73017; AKA73017; SULB_0625
    AKA75715; AKA75715; SULC_0623
    AKA78407; AKA78407; SULA_0623
    GeneIDi44128564
    KEGGissoa:SULA_0623
    ssof:SULC_0623
    ssol:SULB_0625
    PATRICifig|2287.6.peg.649

    Phylogenomic databases

    KOiK00174
    OrthoDBi41678at2157

    Family and domain databases

    Gene3Di3.40.50.920, 1 hit
    InterProiView protein in InterPro
    IPR022367, 2-oxoacid/accept_OxRdtase_asu
    IPR033412, PFOR_II
    IPR019752, Pyrv/ketoisovalerate_OxRed_cat
    IPR002880, Pyrv_Fd/Flavodoxin_OxRdtase_N
    IPR002869, Pyrv_flavodox_OxRed_cen
    IPR029061, THDP-binding
    IPR009014, Transketo_C/PFOR_II
    PfamiView protein in Pfam
    PF17147, PFOR_II, 1 hit
    PF01558, POR, 1 hit
    PF01855, POR_N, 1 hit
    SUPFAMiSSF52518, SSF52518, 1 hit
    SSF52922, SSF52922, 1 hit
    SSF53323, SSF53323, 1 hit
    TIGRFAMsiTIGR03710, OAFO_sf, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOFOA_SACSO
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0E3JT70
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
    Last sequence update: June 24, 2015
    Last modified: June 17, 2020
    This is version 27 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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