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Protein

Cytochrome c oxidase subunit 1

Gene

CO1

Organism
Polypedilum sp. 'nubifer_lookalike'
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:CO1Imported
Encoded oniMitochondrionImported
OrganismiPolypedilum sp. 'nubifer_lookalike'Imported
Taxonomic identifieri1636521 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraChironomoideaChironomidaeChironominaePolypedilumunclassified Polypedilum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 40HelicalSequence analysisAdd BLAST27
Transmembranei52 – 79HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 104COX1InterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A0E3JK99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSSSIAHSGA SVDLAIFSLH LAGVSSILGS VNFITTVINM RSNGITLDRM
60 70 80 90 100
PLFVWSIVIT TVLLLLSLPV LAGAITMLLT DRNLNTSFFD PAGGGDPILY

QHLF
Length:104
Mass (Da):11,043
Last modified:June 24, 2015 - v1
Checksum:i24D6A2F8015980E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei104Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP461699 Genomic DNA Translation: AKA62220.1
KP461700 Genomic DNA Translation: AKA62221.1
KP461701 Genomic DNA Translation: AKA62222.1
KP461702 Genomic DNA Translation: AKA62223.1
KP461703 Genomic DNA Translation: AKA62224.1
KP461704 Genomic DNA Translation: AKA62225.1
KP461705 Genomic DNA Translation: AKA62226.1
KP461706 Genomic DNA Translation: AKA62227.1
KP461707 Genomic DNA Translation: AKA62228.1
KP461708 Genomic DNA Translation: AKA62229.1
KP461709 Genomic DNA Translation: AKA62230.1
KP461710 Genomic DNA Translation: AKA62231.1
KP461711 Genomic DNA Translation: AKA62232.1
KP461712 Genomic DNA Translation: AKA62233.1
KP461713 Genomic DNA Translation: AKA62234.1
KP461714 Genomic DNA Translation: AKA62235.1
KP461715 Genomic DNA Translation: AKA62236.1
KP461716 Genomic DNA Translation: AKA62237.1
KP461717 Genomic DNA Translation: AKA62238.1
KP461718 Genomic DNA Translation: AKA62239.1
KP461719 Genomic DNA Translation: AKA62240.1
KP461720 Genomic DNA Translation: AKA62241.1
KP461721 Genomic DNA Translation: AKA62242.1
KP461722 Genomic DNA Translation: AKA62243.1
KP461723 Genomic DNA Translation: AKA62244.1
KP461862 Genomic DNA Translation: AKA62383.1
KP461863 Genomic DNA Translation: AKA62384.1
KP461864 Genomic DNA Translation: AKA62385.1
KP462186 Genomic DNA Translation: AKA62707.1
KP462225 Genomic DNA Translation: AKA62746.1
KP462226 Genomic DNA Translation: AKA62747.1
KP462227 Genomic DNA Translation: AKA62748.1
KP462228 Genomic DNA Translation: AKA62749.1
KP462229 Genomic DNA Translation: AKA62750.1
KP462230 Genomic DNA Translation: AKA62751.1
KP462231 Genomic DNA Translation: AKA62752.1
KP462232 Genomic DNA Translation: AKA62753.1
KP462233 Genomic DNA Translation: AKA62754.1
KP462234 Genomic DNA Translation: AKA62755.1
KP462235 Genomic DNA Translation: AKA62756.1
KP462236 Genomic DNA Translation: AKA62757.1
KP462237 Genomic DNA Translation: AKA62758.1
KP462238 Genomic DNA Translation: AKA62759.1
KP462239 Genomic DNA Translation: AKA62760.1
KP462240 Genomic DNA Translation: AKA62761.1
KP462241 Genomic DNA Translation: AKA62762.1
KP462242 Genomic DNA Translation: AKA62763.1
KP462243 Genomic DNA Translation: AKA62764.1
KP462244 Genomic DNA Translation: AKA62765.1
KP462245 Genomic DNA Translation: AKA62766.1
KP462246 Genomic DNA Translation: AKA62767.1
KP462247 Genomic DNA Translation: AKA62768.1
KP462248 Genomic DNA Translation: AKA62769.1
KP462249 Genomic DNA Translation: AKA62770.1
KP462250 Genomic DNA Translation: AKA62771.1
KP462251 Genomic DNA Translation: AKA62772.1
KP462252 Genomic DNA Translation: AKA62773.1
KP462253 Genomic DNA Translation: AKA62774.1
KP462254 Genomic DNA Translation: AKA62775.1
KP462255 Genomic DNA Translation: AKA62776.1
KP462256 Genomic DNA Translation: AKA62777.1
KP462257 Genomic DNA Translation: AKA62778.1
KP462258 Genomic DNA Translation: AKA62779.1
KP462259 Genomic DNA Translation: AKA62780.1
KP462260 Genomic DNA Translation: AKA62781.1
KP462261 Genomic DNA Translation: AKA62782.1
KP462262 Genomic DNA Translation: AKA62783.1
KP462263 Genomic DNA Translation: AKA62784.1
KP462264 Genomic DNA Translation: AKA62785.1
KP462265 Genomic DNA Translation: AKA62786.1
KP462266 Genomic DNA Translation: AKA62787.1
KP462267 Genomic DNA Translation: AKA62788.1
KP462268 Genomic DNA Translation: AKA62789.1
KP462269 Genomic DNA Translation: AKA62790.1
KP462270 Genomic DNA Translation: AKA62791.1
KP462271 Genomic DNA Translation: AKA62792.1
KP462272 Genomic DNA Translation: AKA62793.1
KP462273 Genomic DNA Translation: AKA62794.1
KP462274 Genomic DNA Translation: AKA62795.1
KP462275 Genomic DNA Translation: AKA62796.1
KP462276 Genomic DNA Translation: AKA62797.1
KP462277 Genomic DNA Translation: AKA62798.1
KP462278 Genomic DNA Translation: AKA62799.1
KP462279 Genomic DNA Translation: AKA62800.1
KP462280 Genomic DNA Translation: AKA62801.1
KP462281 Genomic DNA Translation: AKA62802.1
KP462282 Genomic DNA Translation: AKA62803.1
KP462283 Genomic DNA Translation: AKA62804.1
KP462284 Genomic DNA Translation: AKA62805.1
KP462285 Genomic DNA Translation: AKA62806.1
KP462286 Genomic DNA Translation: AKA62807.1
KP462287 Genomic DNA Translation: AKA62808.1
KP462288 Genomic DNA Translation: AKA62809.1
KP462289 Genomic DNA Translation: AKA62810.1
KP462290 Genomic DNA Translation: AKA62811.1
KP462291 Genomic DNA Translation: AKA62812.1
KP462292 Genomic DNA Translation: AKA62813.1
KP462293 Genomic DNA Translation: AKA62814.1
KP462294 Genomic DNA Translation: AKA62815.1
KP462295 Genomic DNA Translation: AKA62816.1
KP462296 Genomic DNA Translation: AKA62817.1
KP462297 Genomic DNA Translation: AKA62818.1
KP462298 Genomic DNA Translation: AKA62819.1
KP462299 Genomic DNA Translation: AKA62820.1
KP462300 Genomic DNA Translation: AKA62821.1
KP462301 Genomic DNA Translation: AKA62822.1
KP462302 Genomic DNA Translation: AKA62823.1
KP462303 Genomic DNA Translation: AKA62824.1
KP462304 Genomic DNA Translation: AKA62825.1
KP462305 Genomic DNA Translation: AKA62826.1
KP462306 Genomic DNA Translation: AKA62827.1
KP462307 Genomic DNA Translation: AKA62828.1
KP462308 Genomic DNA Translation: AKA62829.1
KP462309 Genomic DNA Translation: AKA62830.1
KP462310 Genomic DNA Translation: AKA62831.1
KP462311 Genomic DNA Translation: AKA62832.1
KP462312 Genomic DNA Translation: AKA62833.1
KP462313 Genomic DNA Translation: AKA62834.1
KP462314 Genomic DNA Translation: AKA62835.1
KP462315 Genomic DNA Translation: AKA62836.1
KP462316 Genomic DNA Translation: AKA62837.1
KP462317 Genomic DNA Translation: AKA62838.1
KP462318 Genomic DNA Translation: AKA62839.1
KP462319 Genomic DNA Translation: AKA62840.1
KP462320 Genomic DNA Translation: AKA62841.1
KP462321 Genomic DNA Translation: AKA62842.1
KP462322 Genomic DNA Translation: AKA62843.1
KP462323 Genomic DNA Translation: AKA62844.1
KP462324 Genomic DNA Translation: AKA62845.1
KP462325 Genomic DNA Translation: AKA62846.1
KP462326 Genomic DNA Translation: AKA62847.1
KP462327 Genomic DNA Translation: AKA62848.1
KP462328 Genomic DNA Translation: AKA62849.1
KP462329 Genomic DNA Translation: AKA62850.1
KP462330 Genomic DNA Translation: AKA62851.1
KP462331 Genomic DNA Translation: AKA62852.1
KP462332 Genomic DNA Translation: AKA62853.1
KP462333 Genomic DNA Translation: AKA62854.1
KP462334 Genomic DNA Translation: AKA62855.1
KP462335 Genomic DNA Translation: AKA62856.1
KP462336 Genomic DNA Translation: AKA62857.1
KP462337 Genomic DNA Translation: AKA62858.1
KP462338 Genomic DNA Translation: AKA62859.1
KP462339 Genomic DNA Translation: AKA62860.1
KP462340 Genomic DNA Translation: AKA62861.1
KP462341 Genomic DNA Translation: AKA62862.1
KP462342 Genomic DNA Translation: AKA62863.1
KP462343 Genomic DNA Translation: AKA62864.1
KP462344 Genomic DNA Translation: AKA62865.1
KP462345 Genomic DNA Translation: AKA62866.1
KP462346 Genomic DNA Translation: AKA62867.1
KP462347 Genomic DNA Translation: AKA62868.1
KP462348 Genomic DNA Translation: AKA62869.1
KP462349 Genomic DNA Translation: AKA62870.1
KP462350 Genomic DNA Translation: AKA62871.1
KP462351 Genomic DNA Translation: AKA62872.1
KP462352 Genomic DNA Translation: AKA62873.1
KP462353 Genomic DNA Translation: AKA62874.1
KP462354 Genomic DNA Translation: AKA62875.1
KP462355 Genomic DNA Translation: AKA62876.1
KP462356 Genomic DNA Translation: AKA62877.1
KP462357 Genomic DNA Translation: AKA62878.1
KP462385 Genomic DNA Translation: AKA62906.1
KP462445 Genomic DNA Translation: AKA62966.1
KP462446 Genomic DNA Translation: AKA62967.1
KP462447 Genomic DNA Translation: AKA62968.1
KP462448 Genomic DNA Translation: AKA62969.1
KP462449 Genomic DNA Translation: AKA62970.1
KP462450 Genomic DNA Translation: AKA62971.1
KP462451 Genomic DNA Translation: AKA62972.1
KP462685 Genomic DNA Translation: AKA63206.1

Similar proteinsi

Entry informationi

Entry nameiA0A0E3JK99_9DIPT
AccessioniPrimary (citable) accession number: A0A0E3JK99
Entry historyiIntegrated into UniProtKB/TrEMBL: June 24, 2015
Last sequence update: June 24, 2015
Last modified: May 23, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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