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Protein

Peptide deformylase

Gene

def

Organism
Streptococcus thermophilus TH1477
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotationSAAS annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131IronUniRule annotation1
Metal bindingi174IronUniRule annotation1
Active sitei175UniRule annotation1
Metal bindingi178IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotationSAAS annotation (EC:3.5.1.88UniRule annotationSAAS annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
ORF Names:Y022_01025Imported
OrganismiStreptococcus thermophilus TH1477Imported
Taxonomic identifieri1436725 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000032033 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A0E2REH7
SMRiA0A0E2REH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E2REH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAQTKIIRA SHMIDMNDII REGNPTLRAV AEDVTLPLSD EDIILGEKMM
60 70 80 90 100
QFLRNSQDPV IAEKMGLRGG VGLAAPQLDI SKRIIAVLVP NPEDAKGNPP
110 120 130 140 150
KEAYSLQEIM YNPKVVAHSV QEAALGNGEG CLSVDRDVPG YVVRHARVTI
160 170 180 190 200
EYFNKEGEKK RIKLRGYDSI VVQHEIDHTN GIMFYDRINK DNPFTIKDGL

LIIE
Length:204
Mass (Da):22,777
Last modified:May 27, 2015 - v1
Checksum:i0E3CA97B1C7E7ADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AZTJ01000010 Genomic DNA Translation: EWM62618.1
RefSeqiWP_011225356.1, NZ_CM003135.1

Genome annotation databases

EnsemblBacteriaiEWM62618; EWM62618; Y022_01025
GeneIDi31939607
PATRICifig|1436725.7.peg.183

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AZTJ01000010 Genomic DNA Translation: EWM62618.1
RefSeqiWP_011225356.1, NZ_CM003135.1

3D structure databases

ProteinModelPortaliA0A0E2REH7
SMRiA0A0E2REH7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEWM62618; EWM62618; Y022_01025
GeneIDi31939607
PATRICifig|1436725.7.peg.183

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0E2REH7_STRTR
AccessioniPrimary (citable) accession number: A0A0E2REH7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 7, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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