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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Porphyromonas gingivalis F0570
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotationSAAS annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processPyrimidine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
ORF Names:HMPREF1555_01805Imported
OrganismiPorphyromonas gingivalis F0570Imported
Taxonomic identifieri1227271 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000016630 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A0E2LNJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 255OMPdecaseInterPro annotationAdd BLAST240

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E2LNJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTKELFDRI CRKCSFLCVG LDTDVKKIPP HLLNEDDPIL AFNKAIIDAT
60 70 80 90 100
AEYCVAFKPN MAFYESMGSF GAHSFEKTIE YIRERYPDQF IIADAKRGDI
110 120 130 140 150
GNTSDMYARS FFEHLKVDAL TVSPYMGEDS ISPFLSYAGK FTVLLALTSN
160 170 180 190 200
KGSQDFQMMR DADGEYLFER VIRISQTWDN AGQLMYVVGA TQASMLKDIR
210 220 230 240 250
EIVPDAFLLV PGVGAQGGSL EDVAEYGMNA HCGLLVNASR SIIYADNTEG
260 270
FAAKAAGEAA AMQRQMEIAL RAKGLI
Length:276
Mass (Da):30,505
Last modified:May 27, 2015 - v1
Checksum:i236DDAC4AC3E1051
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWUW01000130 Genomic DNA Translation: ERJ64548.1
RefSeqiWP_021665831.1, NZ_KI259212.1

Genome annotation databases

EnsemblBacteriaiERJ64548; ERJ64548; HMPREF1555_01805
PATRICifig|1227271.3.peg.1573

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWUW01000130 Genomic DNA Translation: ERJ64548.1
RefSeqiWP_021665831.1, NZ_KI259212.1

3D structure databases

ProteinModelPortaliA0A0E2LNJ4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiERJ64548; ERJ64548; HMPREF1555_01805
PATRICifig|1227271.3.peg.1573

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00120

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0E2LNJ4_PORGN
AccessioniPrimary (citable) accession number: A0A0E2LNJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: December 20, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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