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Entry version 45 (07 Oct 2020)
Sequence version 1 (27 May 2015)
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Protein

Formate acetyltransferase

Gene

pflB

Organism
Streptococcus agalactiae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyruvate fermentation

This protein is involved in step 1 of the subpathway that synthesizes formate from pyruvate.ARBA annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formate acetyltransferase (WA05_11665), Formate acetyltransferase (pflB), Formate acetyltransferase (WA02_11625), Formate acetyltransferase (pflD-2), Formate acetyltransferase (pflB), Formate acetyltransferase (pflB)
This subpathway is part of the pathway pyruvate fermentation, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from pyruvate, the pathway pyruvate fermentation and in Fermentation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferaseImportedARBA annotation, LyaseImported, Transferase
Biological processCarbohydrate metabolism, Glucose metabolismARBA annotation
LigandPyruvateImported

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00920;UER00891

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Formate acetyltransferaseARBA annotation (EC:2.3.1.54ARBA annotation)
Alternative name(s):
Pyruvate formate-lyaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pflBImported
ORF Names:AX245_09600Imported, C6N10_00810Imported, E8E04_10815Imported, F5043_02790Imported, GD434_02510Imported, NCTC6175_00432Imported, NCTC9828_00753Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus agalactiaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1311 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000093122 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000327245 Componenti: Unassembled WGS sequence
  • UP000307731 Componenti: Unassembled WGS sequence
  • UP000254360 Componenti: Unassembled WGS sequence
  • UP000478762 Componenti: Unassembled WGS sequence
  • UP000255140 Componenti: Unassembled WGS sequence
  • UP000297592 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei737Glycine radicalPROSITE-ProRule annotation1

Keywords - PTMi

Organic radicalPROSITE-ProRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 626PFLInterPro annotationAdd BLAST618
Domaini642 – 762Glycine radicalInterPro annotationAdd BLAST121

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.ARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K00656

Database of Orthologous Groups

More...
OrthoDBi
116406at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005949, Form_AcTrfase
IPR019777, Form_AcTrfase_GR_CS
IPR001150, Gly_radical
IPR004184, PFL_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01228, Gly_radical, 1 hit
PF02901, PFL-like, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01255, pyr_form_ly_1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00850, GLY_RADICAL_1, 1 hit
PS51149, GLY_RADICAL_2, 1 hit
PS51554, PFL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0E1EPU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATVKTNTDI FEQAWEGFKG VDWKEKASIA RFVQANYAPY DGDESFLAGA
60 70 80 90 100
TERSLHIKKV IEETKAHYEE TRFPMDTRVA SISELPAGFI DKDNELIFGI
110 120 130 140 150
QNDELFKLNF MPKGGIRMAE TTLKENGYEP DPAVHEIFTK YATTVNDGIF
160 170 180 190 200
RAYTSNIRRA RHAHTVTGLP DAYSRGRIIG VYARLAVYGA DYLMQEKVND
210 220 230 240 250
WNALNDIDEE SIRLREEINL QYQALGEVVK LGDLYGVDVR KPAMNTKEAI
260 270 280 290 300
QWVNIAFMAV CRVINGAATS LGRVPIVLDI FAERDLARGT FTESEIQEFV
310 320 330 340 350
DDFVLKLRTV KFARTKAYDA LYSGDPTFIT TSMAGMGADG RHRVTKMDYR
360 370 380 390 400
FLNTLDNIGN SPEPNLTVLW SDQLPYAFRR YCMSMSHKHS SIQYEGVSTM
410 420 430 440 450
AKEGYGEMSC ISCCVSPLDP ENEDKRHNLQ YFGARVNVMK ALLTGLNGGY
460 470 480 490 500
DDVHKDYKVF DIDPIRDEVL NFDTVKANFE KSLDWLTDTY VDAMNIIHYM
510 520 530 540 550
TDKYNYEAVQ MAFLPSHVRA NMGFGICGFA NTVDSLSAIK YATVKPIRDE
560 570 580 590 600
DGYIYDYETV GDFPRYGEDD DRVDSIAEWL LEAFHGRLAK HKLYKDAEAT
610 620 630 640 650
VSLLTITSNV AYSKQTGNSP VHKGVYLNED GSVNLSKVEF FSPGANPSNK
660 670 680 690 700
AKGGWLQNLN SLSKLDFAHA NDGISLTTQV SPRALGKTFD EQVDNLVTVL
710 720 730 740 750
DGYFENGGQH VNLNVMDLKD VYDKIMNGED VIVRISGYCV NTKYLTPEQK
760 770
TELTQRVFHE VLSMDDALTN
Length:770
Mass (Da):86,796
Last modified:May 27, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AF5DC2EA13723F8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
VYRP01000024 Genomic DNA Translation: KAA9102108.1
WHUI01000005 Genomic DNA Translation: MQP21705.1
MAWT01000022 Genomic DNA Translation: OCM71451.1
UHEO01000001 Genomic DNA Translation: SUN09075.1
UHEW01000005 Genomic DNA Translation: SUN28260.1
PVLP01000001 Genomic DNA Translation: TEB61706.1
SSWV01000016 Genomic DNA Translation: TKK43721.1

NCBI Reference Sequences

More...
RefSeqi
WP_000246708.1, NZ_WNJJ01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AIF87266; AIF87266; EN72_09295
AOQ19731; AOQ19731; BBP08_00130
CND62926; CND62926; ERS039640_00143
CZT40080; CZT40080; SA111_01887
OCM71451; OCM71451; AX245_09600

Database of genes from NCBI RefSeq genomes

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GeneIDi
51066820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sagc:DN94_07725
sage:EN72_09295
sagl:GBS222_1448
sags:SaSA20_1435

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1261567.3.peg.1546

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
VYRP01000024 Genomic DNA Translation: KAA9102108.1
WHUI01000005 Genomic DNA Translation: MQP21705.1
MAWT01000022 Genomic DNA Translation: OCM71451.1
UHEO01000001 Genomic DNA Translation: SUN09075.1
UHEW01000005 Genomic DNA Translation: SUN28260.1
PVLP01000001 Genomic DNA Translation: TEB61706.1
SSWV01000016 Genomic DNA Translation: TKK43721.1
RefSeqiWP_000246708.1, NZ_WNJJ01000002.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAIF87266; AIF87266; EN72_09295
AOQ19731; AOQ19731; BBP08_00130
CND62926; CND62926; ERS039640_00143
CZT40080; CZT40080; SA111_01887
OCM71451; OCM71451; AX245_09600
GeneIDi51066820
KEGGisagc:DN94_07725
sage:EN72_09295
sagl:GBS222_1448
sags:SaSA20_1435
PATRICifig|1261567.3.peg.1546

Phylogenomic databases

KOiK00656
OrthoDBi116406at2

Enzyme and pathway databases

UniPathwayiUPA00920;UER00891

Family and domain databases

InterProiView protein in InterPro
IPR005949, Form_AcTrfase
IPR019777, Form_AcTrfase_GR_CS
IPR001150, Gly_radical
IPR004184, PFL_dom
PfamiView protein in Pfam
PF01228, Gly_radical, 1 hit
PF02901, PFL-like, 1 hit
TIGRFAMsiTIGR01255, pyr_form_ly_1, 1 hit
PROSITEiView protein in PROSITE
PS00850, GLY_RADICAL_1, 1 hit
PS51149, GLY_RADICAL_2, 1 hit
PS51554, PFL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0E1EPU5_STRAG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0E1EPU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: October 7, 2020
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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