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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Klebsiella pneumoniae 30660/NJST258_1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotationSAAS annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotationSAAS annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationSAAS annotation (EC:3.6.1.40UniRule annotationSAAS annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
ORF Names:KPNJ1_05313Imported
OrganismiKlebsiella pneumoniae 30660/NJST258_1Imported
Taxonomic identifieri1420012 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000019583 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA0A0E1CLG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 303Ppx-GppAInterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01524

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E1CLG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSMSSTSLY AAIDLGSNSF HMLVVREVAG SIQTLSRIKR KVRLAAGLNS
60 70 80 90 100
DNTLSAEAME RGWQCLRLFA ERLQDIPPTQ IRVVATATLR LAVNAGEFLA
110 120 130 140 150
KAQEILGTPV QVISGEEEAR LIYQGVAHTT GGADQRLVVD IGGASTELVT
160 170 180 190 200
GTGAQTTSLF SLSMGCVTWL ERYFADRSLT KENFDLAEAA AREVLLPVAD
210 220 230 240 250
VLRYHGWKVC VGASGTVQAL QEIMMAQGMD ERITLAKLQQ LKQRAIQCGR
260 270 280 290 300
LEELEIEGLT LERALVFPSG LAILIAIFSE LNIQCMTLAG GALREGLVYG
310 320 330 340 350
MLHLSVEQDI RSRTLRNIQR RFMIDTEQAQ RVGGLASHLL SQLDGSWELD
360 370 380 390 400
PLSRDLLLSA CALHEIGLSV DFKRAPQHAA YLVNNLDLPG FTPAQKKLIA
410 420 430 440 450
TLLLNQTNAI DLSSLHQQNA VPPRVAEHLC RLLRLAILFA SRRRDDLLPA
460 470 480 490 500
IQLTAQDEQL TLILPGNWLD EHPLGREMVD QECQWQSYVH WILRVASGDT

LK
Length:502
Mass (Da):55,357
Last modified:May 27, 2015 - v1
Checksum:i1B905D0053865948
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006923 Genomic DNA Translation: AHM87705.1

Genome annotation databases

EnsemblBacteriaiAHM87705; AHM87705; KPNJ1_05313
KEGGikpa:KPNJ1_05313
PATRICifig|1420012.3.peg.4957

Similar proteinsi

Entry informationi

Entry nameiA0A0E1CLG5_KLEPN
AccessioniPrimary (citable) accession number: A0A0E1CLG5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: October 25, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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