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Protein

L-lactate dehydrogenase

Gene

ldh2

Organism
Staphylococcus aureus subsp. aureus Z172
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh1), L-lactate dehydrogenase (ldh2)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16NAD; via amide nitrogenUniRule annotation1
Binding sitei37NADUniRule annotation1
Binding sitei42NADUniRule annotation1
Binding sitei68NADUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei104NADUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei146NADUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1
Binding sitei231SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 83NADUniRule annotation2
Nucleotide bindingi121 – 123NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processStress responseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldh2Imported
Synonyms:ldhUniRule annotation
ORF Names:SAZ172_2720Imported
OrganismiStaphylococcus aureus subsp. aureus Z172Imported
Taxonomic identifieri1406863 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000017502 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A0E1APA1
SMRiA0A0E1APA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 145Ldh_1_NInterPro annotationAdd BLAST139
Domaini148 – 312Ldh_1_CInterPro annotationAdd BLAST165

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni123 – 126Substrate bindingUniRule annotation4
Regioni151 – 154Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

KOiK00016

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E1APA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFGKKVVL IGDGSVGSSY AFAMVTQGVA DEFVIIDIAK DKVKADVQDL
60 70 80 90 100
NHGTVHSPSP VDVKAGEYED CKDADLVVIT AGAPQKPGET RLQLVEKNTK
110 120 130 140 150
IMKSIVKSVM DSGFDGYFLI AANPVDILTR FVKEYTGLPA ERVIGSGTVL
160 170 180 190 200
DSARLQYLIS QELGVAPSSV DASIIGEHGD TELAVWSQAN VAGISVYDTL
210 220 230 240 250
KEQTGSEAKA EEIYVNTRDA AYEIIQAKGS TYYGIALALM RISKAILNNE
260 270 280 290 300
NNVLNVSIQL DGQYGGHKGV YLGVPTLVNQ HGAVKIYEMP LSAEEQALFD
310
KSVKTLEDTF DSIKYLLED
Length:319
Mass (Da):34,420
Last modified:May 27, 2015 - v1
Checksum:i7779343BCA8006C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006838 Genomic DNA Translation: AGY90819.1
RefSeqiWP_000846637.1, NC_022604.1

Genome annotation databases

EnsemblBacteriaiAGY90819; AGY90819; SAZ172_2720
KEGGisauz:SAZ172_2720
PATRICifig|1406863.3.peg.2724

Similar proteinsi

Entry informationi

Entry nameiA0A0E1APA1_STAAU
AccessioniPrimary (citable) accession number: A0A0E1APA1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: June 20, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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