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Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus subsp. aureus 71193
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi155ZincUniRule annotation1
Metal bindingi190ZincUniRule annotation1
Metal bindingi193ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 29ATPUniRule annotation8
Nucleotide bindingi95 – 98ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:ST398NM01_2161Imported
OrganismiStaphylococcus aureus subsp. aureus 71193Imported
Taxonomic identifieri1155084 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000005003 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E0VRQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVELSMYE TYHSGWIECI TGSMFSGKSE ELIRRLRRGI YAKQKVVVFK
60 70 80 90 100
PAIDDRYHKE KVVSHNGNAI EAINISKASE IMTHDLTNVD VIGIDEVQFF
110 120 130 140 150
DDEIVSIVEK LSADGHRVIV AGLDMDFRGE PFEPMPKLMA VSEQVTKLQA
160 170 180 190 200
VCAVCGSSSS RTQRLINGKP AKIDDPIILV GANESYEPRC RAHHIVAPSD

NNKEEL
Length:206
Mass (Da):23,030
Last modified:May 27, 2015 - v1
Checksum:i4A14B581CA0DC581
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003045 Genomic DNA Translation: AFH70349.1

Genome annotation databases

EnsemblBacteriaiAFH70349; AFH70349; ST398NM01_2161
KEGGisud:ST398NM01_2161
PATRICifig|1155084.3.peg.1897

Similar proteinsi

Entry informationi

Entry nameiA0A0E0VRQ2_STAA5
AccessioniPrimary (citable) accession number: A0A0E0VRQ2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: March 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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