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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Staphylococcus aureus subsp. aureus 71193
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
ORF Names:ST398NM01_0761Imported
OrganismiStaphylococcus aureus subsp. aureus 71193Imported
Taxonomic identifieri1155084 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000005003 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 26HelicalUniRule annotationAdd BLAST20
Transmembranei58 – 76HelicalUniRule annotationAdd BLAST19
Transmembranei107 – 126HelicalUniRule annotationAdd BLAST20
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Transmembranei172 – 190HelicalUniRule annotationAdd BLAST19
Transmembranei210 – 231HelicalUniRule annotationAdd BLAST22
Transmembranei243 – 264HelicalUniRule annotationAdd BLAST22
Transmembranei276 – 296HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

KOiK06153
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0E0VMU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNESGYIMF IIELIKGIIL GIVEGLTEFA PVSSTGHMIL VDDMWLKSSE
60 70 80 90 100
FLGSQSAFTF KIVIQLGSVF AAAWVFRERF LEILHIGKHK HVEGDNNQQR
110 120 130 140 150
RSKPRRLNLL HVLVGMVPAG ILGLLFDDFI EEHLFSVPTV MIGLFVGAIY
160 170 180 190 200
MIIADKYSVK VKNPQTVDQI NYFQAFVIGI SQAVAMWPGF SRSGSTISTG
210 220 230 240 250
VLMKLNHKAA SDFTFIMAVP IMLAASGLSL LKHYQDIQIA DIPFYILGFL
260 270 280 290
AAFTVGLIAI KTFLHLINKI KLIPFAIYRI ILVIFIAILY FGFGIGKGI
Length:299
Mass (Da):33,234
Last modified:May 27, 2015 - v1
Checksum:i7F18EABBB201CE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003045 Genomic DNA Translation: AFH68984.1

Genome annotation databases

EnsemblBacteriaiAFH68984; AFH68984; ST398NM01_0761
KEGGisud:ST398NM01_0761
PATRICifig|1155084.3.peg.597

Similar proteinsi

Entry informationi

Entry nameiA0A0E0VMU6_STAA5
AccessioniPrimary (citable) accession number: A0A0E0VMU6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: September 27, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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