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Protein

DNA topoisomerase 2

Gene
N/A
Organism
Leersia perrieri
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 2UniRule annotation (EC:5.99.1.3UniRule annotation)
OrganismiLeersia perrieriImported
Taxonomic identifieri77586 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeLeersia
Proteomesi
  • UP000032180 Componenti: Chromosome 2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 567ToprimInterPro annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1047 – 1074Sequence analysisAdd BLAST28
Coiled coili1153 – 1173Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00187 TOP4c, 1 hit
cd03365 TOPRIM_TopoIIA, 1 hit
Gene3Di1.10.268.10, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR013506 Topo_IIA_bsu_dom2
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C
IPR006171 TOPRIM_domain
IPR034157 TOPRIM_TopoII
PANTHERiPTHR10169 PTHR10169, 1 hit
PfamiView protein in Pfam
PF00204 DNA_gyraseB, 1 hit
PF00521 DNA_topoisoIV, 1 hit
PF02518 HATPase_c, 1 hit
PF01751 Toprim, 1 hit
PF16898 TOPRIM_C, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00433 TOP2c, 1 hit
SM00434 TOP4c, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
SSF56719 SSF56719, 1 hit
PROSITEiView protein in PROSITE
PS00177 TOPOISOMERASE_II, 1 hit
PS50880 TOPRIM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A0D9VJV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAARLPL QSSSAHNAAA GGGAGGKTIE EMYQKKTQLE HILLRPDTYI
60 70 80 90 100
GSVEKNTAKL WVFEDGEMVN RDVTYVPGLY KIFDEILVNA ADNKQRDPTM
110 120 130 140 150
DALRVEIDVE ECRISVYNNG DGIPVEIHQE EGVYVPEMIF GHLLTSSNYD
160 170 180 190 200
DNVKKTTGGR NGYGAKLSNI FSTEFVIETA DGRRQKKYKQ VFSENMGKKS
210 220 230 240 250
QPQITKCKQG ENWTRVTFKP DLAKFNMTEL ETDVVALMRK RVVDMAGTLG
260 270 280 290 300
KTVKVELDNE KVPVRSFADY VNLYLKSASN DSADPLPRYF EKVNDRWEVC
310 320 330 340 350
VTLSEGQFQQ VSFVNRIATI KGGTHVDHVT NQIVNPLMDV VKKKNKNAHM
360 370 380 390 400
KAHNVKSHLW VFVNALIDNP AFDSQTKETL TTRPTSFGSE CKLSDDFHKK
410 420 430 440 450
VGNSAIVSNL LSWADYKLSK ELQKTDGSKR SRLAGIPKLE DANDAGGKDS
460 470 480 490 500
PMCTLILTEG DSAKALAMAG ISVVGRDHYG VFPLRGKLLN VREASHKQIM
510 520 530 540 550
DNAEIQNIKK ILGLQHGKQY DSTKGLRYGH LMIMTDQDHD GSHIKGLLIN
560 570 580 590 600
FIHSFWPSLL KIPSFLVEFI TPIIKATNKR NKKVVLSFYS MPDYEQWKES
610 620 630 640 650
LGGNASCWSI KYYKGLGTST SKEGREYFTE IAKHKKDFVW KSAQDDNDIE
660 670 680 690 700
LAFSKKRITD RKQWLSNYQP GNHLDQQEKY IKYSDFINKE LIQFSMADLL
710 720 730 740 750
RSIPSMVDGL KPGQRKILFC SFKRNLVKEI KVAQFSGYVS EHSAYHHGEQ
760 770 780 790 800
SLASTIIGMA QDFVGSNNIN LLMPNGQFGT RDQGGKDAAS ARYIFTELSS
810 820 830 840 850
ITRSIFPKDD DILLNYLNED GQSIEPTWYV PILPMVLVNG SEGIGTGWST
860 870 880 890 900
YIPNYNPRDI VANLRRLLNN EPVEPMDPWY RGFKGSIQKT STKTGGVSYT
910 920 930 940 950
ITGIIEVVDD TTLKITELPI RRWSQDYKEF LESIGGLDKS KEKDKDKGKG
960 970 980 990 1000
KGKGKEKEKK EKDKVIEAFI ETFATHSDDK NVEFLITLSK ESMDIAKQEG
1010 1020 1030 1040 1050
LEKKFKLTTT ISTTNMHLFD SNGIIRKYDT PEDILKEFFE LRLEFYEKRK
1060 1070 1080 1090 1100
IALLENIELE LKKLSNKVRF ILAVVEGDII VNNRKRAELF KELQQKGFDP
1110 1120 1130 1140 1150
FPKKKQRAEP TAVGSTEEDE ENEESPEAAK GVNPSDYEYL LAMAIGTLTL
1160 1170 1180 1190 1200
EKVQELIAEK GRLENDVAEL KKTRPTSLWL RDLDAFEKEL DVLEEKDRLD
1210 1220 1230 1240 1250
AEDRRNTRNT GDGAAPKPAA KRRAKKTATN SQAAESSEGN AAAAVVPKPA
1260 1270 1280 1290 1300
APRKKPAGKA KLAGSDDEDY AAAASKPAAQ KKQPAKASKQ LSEDDDDEVL
1310 1320 1330 1340 1350
ELKDRLAAYN IHDHSEDSAM ETETTEEQAK GKKGRKEPSK RGAAKKALSS
1360 1370 1380 1390 1400
LAEMSDDDGD AIVPTDEDEE EDFAMEVQVE KKGRGRKPVA EKPKPAATRK
1410 1420 1430 1440 1450
RAPAQGKAMR QKVLDEMFKP TEDSSTSAPS PERKVRKMRA SPFHKKSGSV
1460 1470 1480 1490 1500
LQRGSTAAST STADIESSSP SGSSAEPVAA RPQRQIRGNK KSYQEVQELS
1510 1520
DDTDDEVQEI SDDSDFSGSD FGEDDD
Length:1,526
Mass (Da):170,658
Last modified:May 27, 2015 - v1
Checksum:iD0EB3D4D4D7929DE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9VJV1A0A0D9VJV1_9ORYZ
DNA topoisomerase 2
1,484Annotation score:

Genome annotation databases

EnsemblPlantsiLPERR02G23630.1; LPERR02G23630.1; LPERR02G23630
GrameneiLPERR02G23630.1; LPERR02G23630.1; LPERR02G23630

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiLPERR02G23630.1; LPERR02G23630.1; LPERR02G23630
GrameneiLPERR02G23630.1; LPERR02G23630.1; LPERR02G23630

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00187 TOP4c, 1 hit
cd03365 TOPRIM_TopoIIA, 1 hit
Gene3Di1.10.268.10, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR013506 Topo_IIA_bsu_dom2
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C
IPR006171 TOPRIM_domain
IPR034157 TOPRIM_TopoII
PANTHERiPTHR10169 PTHR10169, 1 hit
PfamiView protein in Pfam
PF00204 DNA_gyraseB, 1 hit
PF00521 DNA_topoisoIV, 1 hit
PF02518 HATPase_c, 1 hit
PF01751 Toprim, 1 hit
PF16898 TOPRIM_C, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00433 TOP2c, 1 hit
SM00434 TOP4c, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
SSF56719 SSF56719, 1 hit
PROSITEiView protein in PROSITE
PS00177 TOPOISOMERASE_II, 1 hit
PS50880 TOPRIM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0D9VJV0_9ORYZ
AccessioniPrimary (citable) accession number: A0A0D9VJV0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 7, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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